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Regulation of Human Monocyte Functions by Interleukin-10

  • Chapter
Interleukin-10

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Monocytes and macrophages play an important role in the immune system through their cytotoxic activity, production of mediators and cytokines, ability to phagocytose native and opsonised antigens and pre-sentation of antigenic peptides to T cells. These functions of monocytes/ macrophages are influenced by the action of several cytokines: IFN-γ, GM-CSF, M-CSF and TNF-α activate monocytes, whereas IL-4, IL-13, TGFβ and IL-10 are potent monocyte deactivators. IL-10 plays a major role as dampener of immune responses through its deactivating potential of monocyte/macrophage functions.1,2,3 The activities of IL-10 on mono-cyte functions are the subject of this chapter.

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Authors
  1. René de Waal Malefyt
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  2. Carl G. Figdor
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  3. Jan E. de Vries
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de Waal Malefyt, R., Figdor, C.G., de Vries, J.E. (1995). Regulation of Human Monocyte Functions by Interleukin-10. In: Interleukin-10. Molecular Biology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22038-2_5

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  • DOI: https://doi.org/10.1007/978-3-662-22038-2_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22040-5

  • Online ISBN: 978-3-662-22038-2

  • eBook Packages: Springer Book Archive

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