Abstract
Interleukin-10 (IL-10) is a cytokine that has generated significant excitement since its discovery.1 This cytokine, as discussed elsewhere in this book, exhibits pleiotropic biological activities on various lineages of murine and human cells. These activities, summarized in Figure 13.1, include growth cofactor for some cells, (mast cells,2 thymocytes,3 etc.) as well as, differentiation effects (Ia induction in B cells).4 However, the activity that has generated the most enthusiasm is its ability to downregulate macrophage function5,6 in a variety of ways. The latter effects of IL-10 strongly suggest that it has anti-inflammatory and/or immunomodulatory effects.
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© 1995 Springer-Verlag Berlin Heidelberg
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Zlotnik, A., Freiberg, R.A. (1995). Effects of IL-10 in Lipopolysaccharide- and Superantigen-Induced Lethal Shock In Vivo. In: Interleukin-10. Molecular Biology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22038-2_13
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DOI: https://doi.org/10.1007/978-3-662-22038-2_13
Publisher Name: Springer, Berlin, Heidelberg
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