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Role of GTP-Binding Proteins in FcεRI Signaling

  • Chapter
IgE Receptor (FcεRI) Function in Mast Cells and Basophils

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Direct evidence for the involvement of specific GTPases in the response of mast cells or the related rat basophilic leukemia (RBL-2H3) cells to FcεRI activation is limited. However, several lines of circumstantial evidence point to the crucial role of GTP-binding proteins in the response of mast or RBL-2H3 cells to FcεRI activation. These include the effects of GTP depletion, of inhibition of the isoprenoid pathway and of various inhibitors and stimulators of GTP-binding proteins. Such experiments will be described in the first section of this chapter. Due to my interest in the mechanism of exocytosis, this and the last section are biased towards the secretory responses to activation of FcεRI and of GTP-binding proteins.

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© 1997 Springer-Verlag Berlin Heidelberg

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Koffer, A. (1997). Role of GTP-Binding Proteins in FcεRI Signaling. In: IgE Receptor (FcεRI) Function in Mast Cells and Basophils. Molecular Biology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22022-1_5

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  • DOI: https://doi.org/10.1007/978-3-662-22022-1_5

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