Advertisement

Landmarks in the Unnatural History of SCID-hu Mice

  • Bruno Péault
Part of the Medical Intelligence Unit book series (MIU.LANDES)

Abstract

For many years biomedical research has sought to develop ethically acceptable techniques for studying living human tissues in which structure and function are preserved. Grafts into tolerant laboratory animals was an obvious possibility whose realization was, to a greater or lesser extent, achieved as appropriate hosts became available. Starting more than half a century ago, chicken embryos,1,2 golden hamsters,3 newborn rats4 and immunosuppressed mice5 received, and transiently accepted, transplants of human tissues. With the advent of congenitally athymic nude mice, a partially immunodeficient environment was provided that extended the period of graft survival and so allowed workers to study the development of easily growing solid human tumors and even, to some extent, of human fetal tissues, as reported in 1972 by Povlsen et al.6Important differences were observed in the ability of human fetal rudiments to grow in nude mice: whereas lung development was significant and reproducible, scarcely more than 50% of thymus grafts were accepted and their follow-up was only short-term and limited to histologic analysis. Although encouraging, these pioneering xenotransplantations of human hematopoietic tissues met with little enthusiasm, whereas the development of human pancreatic7 and nervous8 fetal tissues in nude rodents was later reported.

Keywords

SCID Mouse Severe Combine Immunodeficiency Unnatural History Fetal Thymus Human Hematopoiesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Goodpasture EW, Douglas B, Anderson K. A study of human skin grafted upon the chorioallantois of chick embryos. J Exp Med 1938; 68: 891–904.PubMedCrossRefGoogle Scholar
  2. 2.
    Goodpasture EW, Anderson K. Infection of human skin, grafted on the chorioallantois of chick embryos, with the virus of Herpes zoster. Am J Pathol 1944; 20: 447–55.PubMedGoogle Scholar
  3. 3.
    Hambrick Jr GW, Blommberg R. The behavior of human skin, its appendages and tumors in heterologous hosts. J Invest Dermato 1957; 29: 353–65.Google Scholar
  4. 4.
    Steinmuller D. Transplantation immunity in the newborn rat. Exp Zool 1961; 147: 233–57.CrossRefGoogle Scholar
  5. 5.
    Levey RH, Medawar PB. Nature and mode of action of antilymphocytic antiserum. Proc Natl Acad Sci USA 1966; 56: 1130–37.PubMedCrossRefGoogle Scholar
  6. 6.
    Povlsen CO, Skakkebaek NE, Rygaard J et al. Heterotransplantation of human foetal organs to the mouse mutant nude. Nature 1974; 248: 247–49.PubMedCrossRefGoogle Scholar
  7. 7.
    Tuch BE, Ng AB, Jones A et al. Histologic differentiation of human fetal pancreatic explants transplanted into nude mice. Diabetes 1984; 33: 1180–87.PubMedCrossRefGoogle Scholar
  8. 8.
    Bickford-Wimer P, Granholm AC, Bygdeman M et al. Human fetal cerebellar and cortical tissue transplanted to the anterior eye chamber of athymic rats: electrophysiological and structural studies. Proc Nat Acad Sci USA 1987; 84: 5957–61.PubMedCrossRefGoogle Scholar
  9. 9.
    Bosma GC, Custer RP, Bosma MJ. A severe combined immunodeficiency mutation in the mouse. Nature 1983; 301: 527–30.PubMedCrossRefGoogle Scholar
  10. 10.
    Mosier DE, Gulizia RJ, Baird SM et al. Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 1988; 335: 256–59.PubMedCrossRefGoogle Scholar
  11. 11.
    Kamel-Reid S, Dick JE. Engraftment of immune-deficient mice with human hematopoietic stem cells. Science 1988; 242: 1706–9.PubMedCrossRefGoogle Scholar
  12. 12.
    Lapidot T, Pflumio F, Doedens M et al Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice. Science 1992; 255: 1137–41.PubMedCrossRefGoogle Scholar
  13. 13.
    McCune JM, Namikawa R, Kaneshima H et al. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science 1988; 241: 1632–39.PubMedCrossRefGoogle Scholar
  14. 14.
    Péault B, Namikawa R, Krowka J et al. Experimental human hematopoiesis in immunodeficient SCID mice engrafted with fetal blood-forming organs. In: Edwards RG, ed. Fetal Tissue Transplants in Medicine. Cambridge: Cambridge University Press, 1992: 77–95.Google Scholar
  15. 15.
    Namikawa R, Weilbaecher KN, Kaneshima H et al. Long-term human hematopoiesis in the SCID-hu mouse. J Exp Med 1990; 172: 1055–63.PubMedCrossRefGoogle Scholar
  16. 16.
    Krowka JF, Sarin S, Namikawa R et al. Human T cells in the SCID-hu mouse are phenotypically normal and functionally competent. J Immunol 1991; 146: 3751–56.PubMedGoogle Scholar
  17. 17.
    Vandekerckhove BA, Krowka JF, McCune JM et al. Clonal analysis of the peripheral T cell compartment of the SCID-hu mouse. J Immunol 1991; 146: 4173–79.PubMedGoogle Scholar
  18. 18.
    Vandekerckhove BA, Namikawa R, Bacchetta R et al. Human hematopoietic cells and thymic epithelial cells induce tolerance via different mechanisms in the SCID-hu mouse thymus. J Exp Med 1992; 175: 1033–43.PubMedCrossRefGoogle Scholar
  19. 19.
    Vandekerckhove BA, Baccala R, Jones D et al. Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice. J Exp Med 1992; 176: 1619–24.PubMedCrossRefGoogle Scholar
  20. 20.
    Baccala R, Vandekerckhove BA, Jones D et al. Bacterial superantigens mediate T cell deletions in the mouse severe combined immunodeficiency-human liver/thymus model. J Exp Med 1993; 177: 1481–85.PubMedCrossRefGoogle Scholar
  21. 21.
    Waller EK, Sen-Majumdar A, Kamel OW et al. Human T-cell development in SCID-hu mice: staphylococcal enterotoxins induce specific clonal deletions, proliferation, and anergy. Blood 1992; 80: 3144–56.PubMedGoogle Scholar
  22. 22.
    Namikawa R, Kaneshima H, Lieberman M et al. Infection of the SCID-hu mouse by HIV-1. Science 1988; 242: 1684–86.PubMedCrossRefGoogle Scholar
  23. 23.
    Bonyhadi ML, Rabin L, Salimi S et al. HIV induces thymus depletion in vivo. Nature 1993; 363: 728–32.PubMedCrossRefGoogle Scholar
  24. 24.
    Aldrovandi GM, Feuer G, Gao L et al. The SCID-hu mouse as a model for HIV-1 infection. Nature 1993; 363: 732–36.PubMedCrossRefGoogle Scholar
  25. 25.
    Mocarski ES, Bonyhadi M, Salimi S et al. Human cytomegalovirus in a SCID-hu mouse: thymic epithelial cells are prominent targets of viral replication. Proc Natl Acad Sci USA 1993; 90: 104–8.PubMedCrossRefGoogle Scholar
  26. 26.
    Robinson R, Jordan R. Thymus in vitro. Immunol Today 1983; 4: 41–45.CrossRefGoogle Scholar
  27. 27.
    Péault B, Weissman IL, Baum C et al. Lymphoid reconstitution of the human fetal thymus in SCID mice with CD34* precursor cells. J Exp Med 1991; 174: 1283–86.PubMedCrossRefGoogle Scholar
  28. 28.
    Kyoizumi S, Baum CM, Kaneshima H et al. Implantation and maintenance of functional human bone marrow in SCID-hu mice. Blood 1992; 79: 1704–11.PubMedGoogle Scholar
  29. 29.
    Kyoizumi S, Murray LJ, Namikawa R. Preclinical analysis of cytokine therapy in the SCID-hu mouse. Blood 1993; 81: 1479–88.PubMedGoogle Scholar
  30. 30.
    Kyoizumi S, McCune JM, Namikawa R. Direct evaluation of radiation damage in human hematopoietic progenitor cells in vivo. Radiat Res 1994; 137: 76–83.PubMedCrossRefGoogle Scholar
  31. 31.
    Namikawa R, Ueda R, Kyoizumi S. Growth of human myeloid leukemias in the human marrow environment of SCID-hu mice. Blood 1993; 82: 2526–36.PubMedGoogle Scholar
  32. 32.
    Baum CM, Weissman IL, Tsukamoto AS et al. Isolation of a candidate human hematopoietic stem-cell population. Proc Nat Acad Sci 1992; 89: 2804–8.PubMedCrossRefGoogle Scholar
  33. 33.
    Chen BP, Galy A, Kyoizumi S et al. Engrafment of human hematopoietic precursor cells with secondary transfer potential in SCID-hu mice. Blood 1994; in press.Google Scholar
  34. 34.
    McCune J, Kaneshima H, Krowka J et al. The SCID-hu mouse: a small animal model for HIV infection and patogenesis. Annu Rev Immunol 1991; 9: 399–429.PubMedCrossRefGoogle Scholar
  35. 35.
    Péault B. Human T-cell lineage development in foetal thymus-engrafted SCID mice. Res Immunol 1994; 145: 124–28.PubMedCrossRefGoogle Scholar
  36. 36.
    Kaneshima H, Namikawa R, McCune JM. Human hematolymphoid cells in SCID mice. Curr Opin Immunol 1994; 6: 327–33.PubMedCrossRefGoogle Scholar
  37. 37.
    Le Douarin NM, Dieterlen-Lievre F, Oliver PD. Ontogeny of primary lymphoid organs and lymphoid stem cells. Am J Anat 1984; 170: 261–99.PubMedCrossRefGoogle Scholar
  38. 38.
    Keating A, Singer JW, Kileen PD et al. Donor origin of the in vitro haematopoietic microenvironment after marrow transplantation in man. Nature 1982; 298: 280–83.PubMedCrossRefGoogle Scholar
  39. 39.
    Simmons PJ, Przepiorka D, Thomas ED et al. Host origin of marrow stromal cells following allogeneic bone marrow transplantation. Nature 1987; 328: 429–32.PubMedCrossRefGoogle Scholar
  40. 40.
    Péault B, Tirouvanziam R, Sombardier MN et al. Gene transfer to human fetal pulmonary tissue developed in immunodeficient SCID mice. Hum Gene Ther 1994; 5: 1131–37.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Bruno Péault

There are no affiliations available

Personalised recommendations