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Growth- and Hormone-Related Functions of Glycoproteins and Cell Surface Receptors

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Glycoproteins and Human Disease

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

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Abstract

Development assures cellular diversity and continuation of life from one generation to the next. This is accomplished by differentiation into specialized cell types via asymmetric cell cycle events. For example, α2-Fuc-transferase, blood group B α3-Gal-transferase and blood group A α3-GalNAc-transferase do not appear active on human ova and sperm judged by the absence of ABO blood group reactivity; however, their products appear in early embryogenesis when differentiated epithelium can be demonstrated.1,2 In self-renewing epithelium, alterations in glycoconjugates and glycosyltransferase levels occur as cell cycle-related events.3,4

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  1. Department of Biochemistry, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

    Inka Brockhausen Ph.D. & William Kuhns M.S., M.D.

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Brockhausen, I., Kuhns, W. (1997). Growth- and Hormone-Related Functions of Glycoproteins and Cell Surface Receptors. In: Glycoproteins and Human Disease. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-21960-7_11

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