Skip to main content
SpringerLink
Log in
Book cover

Yearbook of Intensive Care and Emergency Medicine 2000 pp 63–71Cite as

The Influence of Nutrition on Mucosal Immunology and Endothelial Cell Adhesion Molecules

  • Conference paper

  • 236 Accesses

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 2000))

Abstract

The incidence of pneumonia and intra-abdominal abscess decreases when critically injured patients are fed enterally as opposed to intravenously or not at all [1, 2]. Our work has focused on mechanisms underlying these clinical findings. In attempting to determine how nutrient, hormonal, or pharmacologic manipulation improves immune dysfunction occurring in fasted or intravenously fed patients, the key question has been: Why does the route of nutrition impair respiratory tract defenses in critically ill patients? To pursue this issue one must understand the normal mechanisms of defense at mucosal surfaces. Our work has demonstrated a key link between the gastrointestinal tract and respiratory immunity with important observations that route of nutrition influences the structure and function of the gut-associated lymphoid tissue (GALT) [3]. GALT cellular changes influence the cytokine environment, IgA production, endothelial cell activation and recruitment.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Kudsk KA, Croce MA, Fabian TC, et al (1992) Enteral versus parenteral feeding: Effects on septic morbidity following blunt and penetrating abdominal trauma. Ann Surg 215: 503–513

    Article  PubMed  CAS  Google Scholar 

  2. Moore FA, Moore EE, Jones TN, McCroskey BL, Peterson VM (1989) TEN versus TPN following major abdominal trauma-reduces septic morbidity. J Trauma 29: 916–923

    Article  PubMed  CAS  Google Scholar 

  3. Kudsk KA (1999) Influence of nutrition on mucosal immunity. In: Vincent J-L (ed) Yearbook of intensive care and emergency medicine. Springer, Berlin, pp 64–72

    Google Scholar 

  4. Phillips-Quagliata JM, Lamm ME (1994) Lymphocyte homing to mucosal effector sites. In: Ogra PL, Lamm ME, McGhee JR, Mestecky J, Strober W, Bienenstock J (eds) Handbook of mucosal immunology. Academic Press, San Diego, pp 225–239

    Google Scholar 

  5. Li J, Kudsk KA, Gocinski B, et al (1995) Effects of parenteral and enteral nutrition on gut-associated lymphoid tissue. J Trauma 39: 44–52

    Article  PubMed  CAS  Google Scholar 

  6. King BK, Li J, Kudsk KA (1997) A temporal study of TPN-induced changes in gut-associated lymphoid tissue and mucosal immunity. Arch Surg 123: 1303–1309

    Article  Google Scholar 

  7. Kudsk KA, Li J, Renegar KB (1996) Loss of upper respiratory tract immunity with parenteral feeding. Ann Surg 223: 629–638

    Article  PubMed  CAS  Google Scholar 

  8. King BK, Kudsk KA, Li J, Wu Y, Renegar KB (1999) Route and type of nutrition influence muco-sal immunity to bacterial pneumonia. Ann Surg 229: 272–278

    Article  PubMed  CAS  Google Scholar 

  9. Schaberg DR, Culver DH, Gaynes RP (1991) Major trends in microbial etiology of nosocomial infection. Am J Med 16 (suppl 3B): 72S - 75S

    Article  Google Scholar 

  10. Brewer SC, Wunderink RG, Jones CB, Leeper KV (1996) Ventilator associated pneumonia due to Pseudomonas aeruginosa. Chest 109: 1019–1029

    Article  Google Scholar 

  11. Fagon JY, Chastre J, Hence AJ, Montravers P, Novara A, Gilbert C (1993) Nosocomial pneumonia in ventilated patients: A cohort study evaluating attributable mortality and hospital stay. Am J Med 94: 281–288

    Article  PubMed  CAS  Google Scholar 

  12. Abraham E (1992) Intranasal immunization with bacterial polysaccharide containing liposomes enhances antigen-specific pulmonary secretory response. Vaccine 10: 461–468

    Article  PubMed  CAS  Google Scholar 

  13. Mosmann TR, Coffman RL (1989) Thl and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7: 145–173

    Article  PubMed  CAS  Google Scholar 

  14. Kramer DR, Sutherland RM, Bao S, Husband AJ (1995) Cytokine-mediated effects in mucosal immunity. Immunol Cell Biol 73: 389–396

    Article  PubMed  CAS  Google Scholar 

  15. Lebman DA, Coffman RL (1994) Cytokines in the mucosal immune system. In: Ogra PL, Lamm ME, McGhee JR, Mestecky J, Strober W, Bienenstock J (eds) Handbook of mucosal immunology. Academic Press, San Diego, pp 243–249

    Google Scholar 

  16. Souba WW (1991) Glutamine: a key substrate for the splanchnic bed. 11: 285–308

    CAS  Google Scholar 

  17. O’Dwyer ST, Smith RJ, Hwang TL, et al (1989) Maintenance of small bowel mucosa with glutamine-enriched parenteral nutrition. J Parent Enteral Nutr 13: 579–585

    Article  Google Scholar 

  18. Burke DJ, Alverdy JC, Aoys, et al (1989) Glutamine-supplemented total parenteral nutrition improves gut immune function. Arch Surg 124: 1396–1399

    Article  PubMed  CAS  Google Scholar 

  19. Li J, Kudsk KA, Janu P, Renegar KB (1997) Effect of glutamine-enriched total parenteral nutrition on small intestinal gut-associated lymphoid tissue and upper respiratory tract immunity. Surgery 121: 542–549

    Article  PubMed  CAS  Google Scholar 

  20. Dewitt RC, Wu Y, Renegar KB, Kudsk KA (2000) Glutamine-enriched total parenteral nutrition preserves respiratory immunity and improves survival to a Pseudomonas pneumonia. J Surg Res 84: 13–18

    Article  Google Scholar 

  21. Haskel Y, Xu D, Lu Q (1994) Bombesin protects against bacterial translocation induced by three commercially available liquid enteral diets: a prospective, randomized, multigroup trial. Crit Care Med 22: 108–113

    PubMed  CAS  Google Scholar 

  22. Jin GF, Guo YS, Houston CW (1989) Bombesin: an activator of specific aeromonas antibody secretion in rat intestine. Dig Dis Sci 34: 1708–1712

    Article  PubMed  CAS  Google Scholar 

  23. DeWitt RC, Wu Y, Renegar KB, King BK, Li J, Kudsk KA (1999) Bombesin recovers gut-associated lymphoid tissue (GALT) and preserves immunity to bacterial pneumonia in TPN-fed mice. Ann Surg (in press)

    Google Scholar 

  24. Meyer J, Davis J (1991) The neutrophil. In: Davis JM, Shires GT (eds) Principles and management of surgical infections. Lippincott, Philadelphia, pp 521–543

    Google Scholar 

  25. Carlos T, Harlan J (1994) Leukocyte-endothelial adhesion molecules. Blood 84: 2068–2101

    PubMed  CAS  Google Scholar 

  26. Moore E, Moore F, Franciose R, Kim F, Biffl W, Banerjee A (1994) The postischemic gut serves as a priming bed for circulating neutrophils that provoke multiple organ failure. J Trauma 37: 881–887

    Article  PubMed  CAS  Google Scholar 

  27. Fukatsu K, Lundberg AH, Hanna MK, et al (1999) Route of nutrition influences intercellular adhesion molecule-1 expression and neutrophil accumulation in intestine. Arch Surg 134: 1055–1060

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. B. L. Zarzaur
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Fukatsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. A. Kudsk
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Head Department of Intensive Care) (Head Department of Intensive Care)

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Zarzaur, B.L., Fukatsu, K., Kudsk, K.A. (2000). The Influence of Nutrition on Mucosal Immunology and Endothelial Cell Adhesion Molecules. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 2000. Yearbook of Intensive Care and Emergency Medicine, vol 2000. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-13455-9_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-13455-9_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-66830-5

  • Online ISBN: 978-3-662-13455-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation