Abstract
Candida infection as a local problem is well recognized in the normal population but even more commonly encountered in populations with impaired immune responses and increased susceptibility to Candida colonization. There is a gradation of colonization from that which is asymptomatic, through symptomatic, and at the far end of the spectrum the septicemic version of the disease. Paradoxically the complexity of diagnosis increases with the severity of the disease such that Candida septicemia is difficult to diagnose.
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References
Alexander JW, Boyce ST, Babcock GF, et al (1990) The process of microbial translocation. Ann Surg 212: 496–510
Berg R, Bernasconi P, Fowler D, Gautreaux M (1993) Inhibition of Candida albicans translocation from the gastrointestinal tract of mice by oral administration of Saccharomyces boulardii. J Infect Dis 168: 1314–1318
Damjanovic V, Connolly CM, van Saene HK, et al (1993) Selective decontamination with nystatin for control of a Candida outbreak in a neonatal intensive care unit. J Hosp Infect 24: 245–259
Inoue S, Peck MD, Alexander JW (1991) Fungal translocation is associated with increased mortality after thermal injury in guinea pigs. J Burn Care Rehabil 12: 19–22
Wells CL (1990) Relationship between intestinal microecology and the translocation of intestinal bacteria. Antonie Van Leeuwenhoek 58: 87–93
Jarvis WR, Martone WJ (1992) Predominant pathogens in hospital infections. J Antimicrob Chemother 29: 19–24
Jarvis WR (1995) Epidemiology of nosocomial fungal infections, with emphasis on Candida species. Clin Infect Dis 20: 1526–1530
Harvey RL, Myers JP (1987) Nosocomial fungemia in a large community teaching hospital. Arch Intern Med 147: 2117–2120
Anaissie E, Bodey GP (1989) Nosocomial fungal infections. Old problems and new challenges. Infect Dis Clin North Am 3: 867–882
Beck Sague C, Jarvis WR (1993) Secular trends in the epidemiology of nosocomial fungal infections in the United States, 1980–1990. National Nosocomial Infections Surveillance System. J Infect Dis 167: 1247–1251
Morrison AJ Jr, Freer CV, Searcy MA, Landry SM, Wenzel RP (1986) Nosocomial bloodstream infections: secular trends in a statewide surveillance program in Virginia. Infect Control 7: 550–553
Pfaller M, Wenzel R (1992) Impact of the changing epidemiology of fungal infections in the (1990s. Eur J Clin Microbiol Infect Dis 11: 287–291
Safran DB, Dawson E (1997) The effect of empiric and prophylactic treatment with fluconazole on yeast isolates in a surgical trauma intensive care unit. Arch Surg 132: 1184–1189
Wingard JR, Merz WG, Rinaldi MG, Johnson TR, Karp JE, Saral R (1991) Increase in Candida krusei infection among patients with bone marrow transplantation and neutropenia treated prophylactically with fluconazole. N Engl J Med 325: 1274–1277
Abi Said D, Anaissie E, Uzun O, Raad I, Pinzcowski H, Vartivarian S (1997) The epidemiology of hematogenous candidiasis caused by different Candida species. Clin Infect Dis 24: 1122–1128
Plouffe JF, Brown DG, Silva J Jr, Eck T, Stricof RL, Fekety FR Jr (1977) Nosocomial outbreak of Candida parapsilosis fungemia related to intravenous infusions. Arch Intern Med 137: 1686–1689
Huang YC, Lin TY, Peng HL, Wu JH, Chang HY, Leu HS (1998) Outbreak of Candida albicans fungaemia in a neonatal intensive care unit. Scand J Infect Dis 30: 137–142
Huang YC, Lin TY, Leu HS, Peng HL, Wu JH, Chang HY (1999) Outbreak of Candida parapsilosis fungemia in neonatal intensive care units: clinical implications and genotyping analysis. Infection 27: 97–102
Pfaller MA (1994) Epidemiology and control of fungal infections. Clin Infect Dis 19 (suppl 1): S8 - S13
Solomkin JS, Flohr AM, Simmons RL (1982) Indications for therapy for fungemia in postoperative patients. Arch Surg 117: 1272–1275
Krcmery V Jr, Spanik S, Grausova S, et al (1998) Candida parapsilosis fungemia in cancer patients–incidence, risk factors and outcome. Neoplasma 45: 336–342
Nolla-Salas J, Sitges-Serra A, Leon-Gil C, et al (1997) Candidemia in non-neutropenic critically ill patients: analysis of prognostic factors and assessment of systemic antifungal therapy. Study Group of Fungal Infection in the ICU. Intensive Care Med 23: 23–30
Pittet D, Tarara D, Wenzel RP (1994) Nosocomial bloodstream infection in critically ill patients. Excess length of stay, extra costs, and attributable mortality. JAMA 271: 1598–1601
Pittet D, Wenzel RP (1995) Nosocomial bloodstream infections. Secular trends in rates, mortality, and contribution to total hospital deaths. Arch Intern Med 155: 1177–1184
Wenzel RP (1995) Nosocomial candidemia: risk factors and attributable mortality. Clin Infect Dis 20: 1531–1534
Wey SB, Mori M, Pfaller MA, Woolson RF, Wenzel RP (1988) Hospital-acquired candidemia. The attributable mortality and excess length of stay. Arch Intern Med 148: 2642–2645
Palmer DL (1984) Microbiology of pneumonia in the patient at risk. Am J Med 76: 53–60
el Ebiary M, Torres A, Fabregas N, et al (1997) Significance of the isolation of Candida species from respiratory samples in critically ill, non-neutropenic patients. An immediate postmortem histologic study. Am J Respir Crit Care Med 156: 583–590
Pittet D, Monod M, Suter PM, Frenk E, Auckenthaler R (1994) Candida colonization and subsequent infections in critically ill surgical patients. Ann Surg 220: 751–758
Barzotta A, Beardsley K (1999) Candida infection in critically ill trauma patients) a retrospective case-control study. Arch Surg 134: 657–664
Solomkin J, Flohr A, Quie P, Simmons R (1980) The role of Candida in intraperitoneal infections. Surgery 88: 524–530
British S, for Antimicrobial Chemotherapy Working Party (1994) Management of deep Candida infection in surgical and intensive care unit patients. Intensive Care Med 20: 522–528
Nolla Salas J, Leon C, Torres Rodriguez JM, Martin E, Sitges Serra A (1992) Treatment of candidemia in critically ill surgical patients with intravenous fluconazole. Clin Infect Dis 14: 952–954
Odds FC, Vranckx L, Woestenborghs F (1995) Antifungal susceptibility testing of yeasts: evaluation of technical variables for test automation. Antimicrob Agents Chemother 39: 2051–2060
Morace G, Sanguinetti M, Posteraro B, Pagano L (1995) In vitro susceptibility of Candida species isolated from patients with haematological malignancies. Mycoses 38: 59–67
Rodero LL, Davel GO, Vivot W, Canteros CE, Fernandez C (1995) In vitro sensitivity tests for yeasts: evaluation of a micromethod. Rev Argent Microbiol 27: 81–89
Schmalreck AF, Kottmann I, Reiser A, Ruffer U, Scharr E, Vanca E (1995) An evaluation of seven methods of testing in vitro susceptibility of clinical yeast isolates to fluconazole. Mycoses 38: 359–368
Wanger A, Mills K, Nelson PW, Rex JH (1995) Comparison of Etest and National Committee for Clinical Laboratory Standards broth macrodilution method for antifungal susceptibility testing: enhanced ability to detect amphotericin B-resistant Candida isolates. Antimicrob Agents Chemother 39: 2520–2522
Maenza JR, Keruly JC, Moore RD, Chaisson RE, Merz WG, Gallant JE (1996) Risk factors for fluconazole-resistant candidiasis in human immunodeficiency virus-infected patients. J Infect Dis 173: 219–225
Manso E, Montillo M, Discepoli G, Leoni P (1991) Fluconazole resistance of Candida krusei. Boll Ist Sieroter Milan 70: 527–529
Marr KA, White TC, van Burik JA, Bowden RA (1997) Development of fluconazole resistance in Candida albicans causing disseminated infection in a patient undergoing marrow transplantation. Clin Infect Dis 25: 908–910
Sanglard D, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J (1995) Mechanisms of resistance to azote antifungal agents in Candida albicans isolates from AIDS patients involve specific multi-drug transporters. Antimicrob Agents Chemother 39: 2378–2386
Tumbarello M, Tacconelli E, Caldarola G, Morace G, Cauda R, Ortona L (1997) Fluconazole resistant oral candidiasis in HIV-infected patients. Oral Dis 3: S110 - S112
Smith LG (1986) Fungal nosocomial superinfection. N Engl J Med 83: 597–598
Cerra F, Maddaus M, Dunn D, et al (1992) Selective gut decontamination reduces nosocomial infections and length of stay but not mortality or organ failure in surgical intensive care unit patients. Arch Surg 127: 163–169
Desai M, Rutan R, Heggers J, Herndon D (1992) Candida infection with and without nystatin prophylaxis. Arch Surg 127: 159–162
Savino J, Agarwal N, Wry P, Policastro A, Cerabona T, Austria L (1994) Routine prophylactic anti-fungal agents (clotrimazole, ketoconazole, and nystatin) in non transplant, non burned, critically ill surgical and trauma patients. J Trauma 36: 20–26
Lo WK, Chan CY, Cheng SW, Poon JF, Chan DT, Cheng IK (1996) A prospective randomized control study of oral nystatin prophylaxis for Candida peritonitis complicating continuous ambulatory peritoneal dialysis. Am J Kidney Dis 28: 549–552
Lumbreras C, Cuervas Mons V, Jara P, et al (1996) Randomized trial of fluconazole versus nystatin for the prophylaxis of Candida infection following liver transplantation. J Infect Dis 174: 583–588
Ninane J (1994) A multicentre study of fluconazole versus oral polyenes in the prevention of fungal infection in children with hematological or oncological malignancies. Multicentre Study Group. Eur J Clin Microbiol Infect Dis 13: 330–337
Milliken ST, Powles RL (1990) Antifungal prophylaxis in bone marrow transplantation. Rev Infect Dis 12: 5374–5379
Alvarez Alvarez ME, Sanchez Sousa A, Baquero F (1998) A reevaluation of nystatin in prophylaxis and treatment of oropharyngeal candidiasis. Rev Esp Quimioter 11: 295–315
Janknegt R, de Marie S, Bakker-Woudenberg I, Crommelin D (1992) Liposomal and lipid formulations of amphotericin B. Clin Pharmacokinet 23: 279–291
Anaissie EJ, Vartivarian SE, Abi Said D, et al (1996) Fluconazole versus amphotericin B in the treatment of hematogenous candidiasis: a matched cohort study. Am J Med 101: 170–176
Abele Horn M, Kopp A, Sternberg U, et al (1996) A randomized study comparing fluconazole with amphotericin B/5-flucytosine for the treatment of systemic Candida infections in intensive care patients. Infection 24: 426–432
Martino P, Girmenia C (1997) Are we making progress in antifungal therapy? Curr Opin Oncol 9: 314–320
Adler-Moore J, Proffitt R (1993) Development characterization efficacy and mode of action of Ambisome, a unilamellar liposomal formulation of amphotericin B. J Liposomal Res 3: 429–450
Mehta RT, Poddar S, Kalidas M, Gomez Flores R, Dulski K (1997) Role of macrophages in the candidacidal activity of liposomal amphotericin B. J Infect Dis 175: 214–217
Ralph ED, Barber KR, Grant CW (1991) Liposomal amphotericin B: an effective, nontoxic preparation for the treatment of urinary tract infections caused by Candida albicans. Am J Nephrol 11: 118–122
Ralph ED, Khazindar AM, Barber KR, Grant CW (1991) Comparative in vitro effects of liposomal amphotericin B, amphotericin B-deoxycholate, and free amphotericin B against fungal strains determined by using MIC and minimal lethal concentration susceptibility studies and time-kill curves. Antimicrob Agents Chemother 35: 188–191
Lister J (1996) Amphotericin B lipid complex (Abelcet) in the treatment of invasive mycoses: the North American experience. Eur J Haematol 56 (suppl 57): 18–23
White MH, Bowden RA, Sandler ES, et al (1998) Randomized, double-blind clinical trial of amphotericin B colloidal dispersion vs. amphotericin B in the empirical treatment of fever and neutropenia. Clin Infect Dis 27: 296–302
Herbrecht R (1997) Safety of amphotericin B colloidal dispersion. Eur J Clin Microbiol Infect Dis 16: 74–80
de Marie S (1996) Liposomal and lipid-based formulations of amphotericin B. Leukemia 10: S93 - S96
Noskin GA, Pietrelli L, Coffey G, Gurwith M, Liang LJ (1998) Amphotericin B colloidal dispersion for treatment of candidemia in immunocompromised patients. Clin Infect Dis 26: 461–467
Anaissie EJ, Mattiuzzi GN, Miller CB, et al (1998) Treatment of invasive fungal infections in renally impaired patients with amphotericin B colloidal dispersion. Antimicrob Agents Chemother 42: 606–611
Oppenheim BA, Herbrecht R, Kusne S (1995) The safety and efficacy of amphotericin B colloidal dispersion in the treatment of invasive mycoses. Clin Infect Dis 21: 1145–1153
Nicolau DP, Crowe H, Nightingale CH, Quintiliani R (1995) Bioavailability of fluconazole administered via a feeding tube in intensive care unit patients. J Antimicrob Chemother 36: 395–401
Desai MH, Rutan RL, Heggers JP, Herndon DN (1992) Candida infection with and without nystatin prophylaxis. A 11-year experience with patients with burn injury. Arch Surg 127: 159–162
Gupta TP, Ehrinpreis MN (1990) Candida-associated diarrhea in hospitalized patients. Gastroenterology 98: 780–785
Dube MP, Heseltine PN, Rinaldi MG, Evans S, Zawacki B (1994) Fungemia and colonization with nystatin-resistant Candida rugosa in a burn unit. Clin Infect Dis 18: 77–82
Sheridan RL, Weber JM, Budkevich LG, Tompkins RG (1995) Candidemia in the pediatric patient with burns. J Burn Care Rehabil 16: 440–443
Slotman G, Burchard K (1987) Ketoconazole prevents Candida sepsis in critically ill surgical patients. Arch Surg 122: 147–151
Girmenia C, Martino P, Cassone A (1996) Breakthrough candidemia during antifungal treatment with fluconazole in patients with hematologic malignancies. Blood 87: 838–839
Le Guennec R, Reynes J, Mallie M, Pujol C, Janbon F, Bastide JM (1995) Fluconazole-and itraconazole-resistant Candida albicans strains from AIDS patients: multilocus enzyme electrophoresis analysis and antifungal susceptibilities. J Clin Microbiol 33: 2732–2737
Wingard JR, Merz WG, Rinaldi MG, Miller CB, Karp JE, Saral R (1993) Association of Torulopsis glabrata infections with fluconazole prophylaxis in neutropenic bone marrow transplant patients. Antimicrob Agents Chemother 37: 1847–1849
Epstein JB, Ransier A, Lunn R, et al (1996) Prophylaxis of candidiasis in patients with leukemia and bone marrow transplants. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 81: 291–296
Eggiman P, Francioli P, Schneider R, et al (1999) Fluconazole prophylaxis prevents intra-abdominal candidiasis in high risk surgical patients. Crit Care Med 27: 1066–1072
Rex 1 (1996) Catheters and candidemia. Clin Infect Dis 22: 467–469
Rex J, Bennett J, Sugar A, et al (1994) A randomized trial comparing fluconazole with amphotericin B for the treatment of candidemia in patients without neutropenia. N Engl J Med 331: 1325–1330
Nguyen MH, Peacock JE Jr, Tanner DC, et al (1995) Therapeutic approaches in patients with candidemia. Evaluation in a multicenter, prospective, observational study. Arch Intern Med 155: 2429–2435
Graninger W, Presteril E, Schneeweiss B, Teleky B, Georgopoulos A (1993) Treatment of Candida albicans fungaemia with fluconazole. J Infect 26: 133–146
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Soni, N. (2000). Candida: Some Thoughts. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 2000. Yearbook of Intensive Care and Emergency Medicine, vol 2000. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-13455-9_13
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DOI: https://doi.org/10.1007/978-3-662-13455-9_13
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