Skip to main content

Pro-Inflammatory Cytokine Genomic Polymorphism and Critical Illness

  • Conference paper
Book cover Yearbook of Intensive Care and Emergency Medicine 1999

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1999))

Abstract

The nature and magnitude of the inflammatory response to tissue injury is an important element in the development of multi-organ dysfunction in the critically ill. In some cases, this response may be greater than that required to deal with the original insult and as a consequence rather than promoting resolution and healing, may result in injury to diverse organs and tissues.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Sorensen T, Neilsen G, Andersen P, Teasdale T (1988) Genetic and environmental influences on premature death in adult adoptees. N Engl J Med 318:727–732.

    Article  PubMed  CAS  Google Scholar 

  2. Bellamy R, Hill A (1998) Genetic susceptibility to mycobacteria and other infectious pathogens in humans. Curr Opin Immunol 10:483–487.

    Article  PubMed  CAS  Google Scholar 

  3. Jacob C, Froznek Z, Lewis G, Koo M, Hansen J, McDevitt H (1990) Heritable MHC class-2 associated differences in production of TNF-alpha: relevance to genetic predisposition to systemic lupus erythematosis. Proc Natl Acad Sci USA 87:1233–1237.

    Article  PubMed  CAS  Google Scholar 

  4. Dannis V, Millington M, Hyland V, Grennan D (1995) Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist gene polymorphism. Clin Exp Immunol 99:303–310.

    Article  Google Scholar 

  5. Santtila S, Savinainen K, Hurme M (1998) Presence of the IL-IRA allele 2 (IL1RN*2) is associated with enhanced IL-IB production in vitro. Scand J Immunol 47:195–198.

    Article  PubMed  CAS  Google Scholar 

  6. Schraut W, Wendelgass P, Calzada-Wack J, Frankenberger M, Ziegler-Heitbrock H (1997) TNF gene expression in monocytes of low and high responder individuals. Cytokine 9:206–211.

    Article  PubMed  CAS  Google Scholar 

  7. Wilson A, Giovine Fd, Duff G (1995) Genetics of tumor necrosis factor-alpha in autoimmune, infectious and neoplastic diseases. J Inflamm 45:1–12.

    PubMed  CAS  Google Scholar 

  8. Nicklin M, Weith A, Duff G (1994) A physical map of the region encompassing the human inter-leukin 1-α, interleukin 1-β and interleukin-1 receptor antagonist genes. Genomics 19:382–384.

    Article  PubMed  CAS  Google Scholar 

  9. Douzinas E, Tsidemiadou P, Potaridis M, et al (1997) The regional production of cytokines and lactate in sepsis related multiple organ failure. Am J Respir Crit Care Med 155:53–59.

    PubMed  CAS  Google Scholar 

  10. Keel M, Ecknauer E, Stocker R, et al (1996) Different pattern of local and systemic release of proinflammatory and anti-inflammatory mediators in severely injured patients with chest trauma. J Trauma 40:907–912.

    Article  PubMed  CAS  Google Scholar 

  11. Martich GD, Boujoukos AJ, Suffredini AF (1993) Response of man to endotoxin. Immunobiology 187:403–416.

    Article  PubMed  CAS  Google Scholar 

  12. Dinarello C (1996) Biologic basis for interleukin-1 in disease. Blood 87:2095–2147.

    PubMed  CAS  Google Scholar 

  13. Mansfield JC, Holden H, Tarlow JK, et al (1994) Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist. Gastroenterology 106:637–642.

    PubMed  CAS  Google Scholar 

  14. Heresbach D, Alizadeh M, Dabadie A, et al (1997) Significance of interleukin-1b and interleukin-1 receptor antagonist genetic polymorphism in inflammatory bowel diseases. Am J Gastroenterol 92:1164–1169.

    PubMed  CAS  Google Scholar 

  15. Kornman KS, Crane A, Wang HY, et al (1997) The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol 24:72–77.

    Article  PubMed  CAS  Google Scholar 

  16. Tarlow J, Clay F, Cork M, et al (1994) Severity of alopecia areata is associated with a polymorphism in the interleukin-1 receptor antagonist gene. J Invest Dermatol 103:387–390.

    Article  PubMed  CAS  Google Scholar 

  17. Pociot F, Molvig J, Worgensen L, Worsaae H, Nerup J (1992) A Taq 1 polymorphism in the human IL-1b gene correlates with IL-1b secretion in vivo. Eur J Clin Invest 22:396–402.

    Article  PubMed  CAS  Google Scholar 

  18. Andus T, Daig R, Aschenbrenner E, et al (1997) Imbalance of the interleukin 1 system in colonic mucosa-association with intestinal inflammation and interleukin 1 receptor antagonist genotype 2. Gut 41:651–657.

    Article  PubMed  CAS  Google Scholar 

  19. Fanning GC, Bunce M, Black CM, Walsh KI (1997) Polymerase chain reaction haplotyping using 3 ′ mismatches in the forward and reverse primers: application to the biallelic polymorphisms of tumor necrosis factor and lymphotoxin alpha. Tissue Antigens 50:23–31.

    Article  PubMed  CAS  Google Scholar 

  20. Wilson AG, de Vries N, Pociot F, di Giovine FS, van der Putte LB, Duff GW (1993) An allelic polymorphism within the human tumour necrosis factor alpha promotor region is strongly associated with HLA A1, B8, DR3 alleles. J Exp Med 177:557–560.

    Article  PubMed  CAS  Google Scholar 

  21. Stuber F, Udalova I, Book M, et al (1996)-308 tumour necrosis factor (TNF) is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter. J Inflamm 46:42–50.

    CAS  Google Scholar 

  22. Bouma G, Crusius J, Pool MO, et al (1996) Secretion of tumour necrosis factor alpha and lymphotoxin alpha in relation to polymorphisms in the TNF genes and HLA-DR alleles. Relevance for inflammatory bowel disease. Scand J Immunol 43:456–463.

    Article  PubMed  CAS  Google Scholar 

  23. Brinkman B, Zuijdgeest D, Kaijzel E, Breedveld F, Verweij C (1996) Relevance of the tumor necrosis factor alpha (TNFα) —308 promotor polymorphism in TNFa gene regulation. J Inflamm 46:32–41.

    CAS  Google Scholar 

  24. Louis E, Franchimont D, Piron A, et al (1998) Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS) stimulated whole blood cell culture in healthy humans. Clin Exp Immunol 113:401–406.

    Article  PubMed  CAS  Google Scholar 

  25. Wilson A, Symons J, McDowell T, McDevitt H, Duff G (1997) Effects of a polymorphism in the human tumor necrosis factor alpha promotor on transcriptional activation. Proc Natl Acad Sci USA 94:3195–3199.

    Article  PubMed  CAS  Google Scholar 

  26. Stuber F, Petersen M, Bokelmann F, Schade U (1996) A genomic polymorphism within the tumor necrosis factor locus influences plasma tumour necrosis factor alpha concentrations and outcome of patients with severe sepsis. Crit Care Med 24:381–384.

    Article  PubMed  CAS  Google Scholar 

  27. Pociot F, Molvig J, Wogensen L, et al (1991) A tumour necrosis factor beta polymorphism in relation to monokine secretion and insulin dependant diabetes mellitus. Scand J Immunol 33: 37–49.

    Article  PubMed  CAS  Google Scholar 

  28. Pociot F, Briant L, Jongeneel CV, et al (1993) Association of tumour necrosis factor (TNF) and class II major histocompatability alleles with the secretion of TNF alpha and TNF beta by human mononuclear cells; a possible link to insulin dependant diabetes mellitus. Eur Immunol 23:224–231.

    Article  CAS  Google Scholar 

  29. Bettinotti M, Hartung K, Deicher H, et al (1993) Polymorphism of the tumour necrosis factor beta gene in systemic lupus erythematosis: TNF-MHC haplotypes. Immunogenetics 37: 449–454.

    Article  PubMed  CAS  Google Scholar 

  30. Grau G, Taylor T, Moleyneux M, et al (1989) Tumor necrosis factor and disease severity in children with falciparum malaria. N Engl J Med 320:1586–1591.

    Article  PubMed  CAS  Google Scholar 

  31. Clark I, Rockett K, Cowden W (1992) Possible central role of nitric oxide in conditions clinically similar to cerebral malaria. Lancet 340:894–895.

    Article  PubMed  CAS  Google Scholar 

  32. Mcguire W, Hill V, Allsopp C, Greenwood B, Kwjatkowski D (1994) Variation of TNF-alpha promotor region associated with susceptibility to cerebral malaria. Nature 371:508–511.

    Article  PubMed  CAS  Google Scholar 

  33. Cabrera M, Shaw M, Sharpies C, et al (1995) Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis. J Exp Med 182:1259–1264.

    Article  PubMed  CAS  Google Scholar 

  34. Roy S, McGuire W, Mascie-Taylor C, et al (1997) Tumor necrosis factor promoter polymorphism and susceptibility to lepromatous leprosy. J Infect Dis 176:530–532.

    Article  PubMed  CAS  Google Scholar 

  35. Schirmer W, Schirmer J, Fry D (1989) Recombinant human tumour necrosis factor produces haemodynamic changes characteristic of sepsis and endotoxaemia. Arch Surg 124:445–449.

    Article  PubMed  CAS  Google Scholar 

  36. Waage A, Halstensen A, Espevik T (1987) Association of tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease. Lancet 1:355–357.

    Article  PubMed  CAS  Google Scholar 

  37. Martin C, Boisson C, Haccoun M, Thomachot L, Mege JL (1997) Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock and severe trauma. Crit Care Med 25:1813–1819.

    Article  PubMed  CAS  Google Scholar 

  38. Pinsky M, Vincent JL, Deviere J, Alegre M, Kahn R, Dupont E (1993) Serum cytokine levels in human septic shock: relation to multiple-system organ failure and mortality. Chest 103:565–575.

    Article  PubMed  CAS  Google Scholar 

  39. Nadel S, Newport M, Booy R, Levin M (1996) Variation in the tumor necrosis factor-α gene promotor region may be associated with death from meningococcal disease. J Infect Dis 174: 878–880.

    Article  PubMed  CAS  Google Scholar 

  40. Westendorp R, Langermans J, Huizinga T, et al (1997) Genetic influence on cytokine production and fatal meningococcal disease. Lancet 349:170–173.

    Article  PubMed  CAS  Google Scholar 

  41. Bernal W, Wendon J, Rela M, Heaton N, Williams R (1998) Use and outcome of liver transplantation in acetaminophen induced acute liver failure. Hepatology 27:1050–1055.

    Article  PubMed  CAS  Google Scholar 

  42. Bihari DJ, Gimson AE, Waterson M, Williams R (1985) Tissue hypoxia during fulminant hepatic failure. Crit Care Med 13:1034–1039.

    Article  PubMed  CAS  Google Scholar 

  43. Bihari DJ, Gimson AE, Williams R (1986) Cardiovascular, pulmonary and renal complications of fulminant hepatic failure. Semin Liver Dis 6:119–128.

    Article  PubMed  CAS  Google Scholar 

  44. Rolando N, Philpott-Howard J, Williams R (1996) Bacterial and fungal infections in acute liver failure. Semin Liver Dis 16:389–402.

    Article  PubMed  CAS  Google Scholar 

  45. Sekiyama K, Yoshiba M, Thompson A (1994) Circulating proinflammatory cytokines (IL-Iβ, TNF-03B1;, and IL-6) and IL-1 receptor antagonist (IL-Ira) in fulminant hepatic failure and acute hepatitis. Clin Exp Immunol 98:71–77.

    Article  PubMed  CAS  Google Scholar 

  46. Muto Y, Nouri-Aria K, Meager A, Alexander G, Eddlestone A, Williams R (1988) Enhanced tumour necrosis factor and interleukin-1 in fulminant liver failure. Lancet 2:72–74.

    Article  PubMed  CAS  Google Scholar 

  47. Goldin R, Ratnayaka I, Breach C, Brown I, Wickramasinghe S (1995) Role of macrophages in acetaminophen (paracetamol) induced hepatotoxicity. J Pathol 179:432–435.

    Article  Google Scholar 

  48. Blazka M, Wilmer J, Holladay S, Wilson R, Luster M (1995) Role of proinflammatory cytokines in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 133:43–52.

    Article  PubMed  CAS  Google Scholar 

  49. Boulton R, Woodman A, Calnan D, Seiden C, Tarn F, Hodgson H (1997) Nonparenchymal cells from regenerating rat liver generate interleukin-1 a and-103B2; a mechanism of negative regulation of hepatocyte proliferation. Hepatology 26:50–58.

    Google Scholar 

  50. Bernal W, Donaldson P, Underhill J, Wendon J, Williams R (1998) Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol) induced acute liver failure. J Hepatol 29:53–59.

    Article  PubMed  CAS  Google Scholar 

  51. Bernal W, Jackson N, Williams R, Wendon J, Donaldson P (1998) Association of IL-1B genotype with poor outcome in paracetamol induced acute liver failure. Hepatology 28:331A (Abst).

    Google Scholar 

  52. Mata M, Meager A, Rolando N, Daniels H, Nouri-Aka K, Williams R (1990) Tumour necrosis factor production in fulminant hepatic failure; relation to aetiology and superimposed microbial infection. Clin Exp Immunol 82:479–484.

    Article  PubMed  Google Scholar 

  53. Moss M, Gillespie MK, Ackerson L, Moore FA, Moore EE, Parsons PE (1996) Endothelial cell activity varies in patients at risk for the adult respiratory distress syndrome. Crit Care Med 24: 1782–1786.

    Article  PubMed  CAS  Google Scholar 

  54. Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV (1997) An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 24:1–8.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Bernal, W., Donaldson, P., Wendon, J. (1999). Pro-Inflammatory Cytokine Genomic Polymorphism and Critical Illness. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1999. Yearbook of Intensive Care and Emergency Medicine, vol 1999. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-13453-5_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-13453-5_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-65288-5

  • Online ISBN: 978-3-662-13453-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics