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Endothelial Cell Adhesion Molecule Expression in Acutely Inflamed Tissues

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine 1997

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1997))

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Abstract

Leukocyte adhesion to vascular endothelium is a hallmark of the inflammatory process. In recent years, many studies have been designed to address the cellular and molecular mechanisms involved with mediating the adhesive interactions between leukocytes and vascular endothelial cells. Significant progress in our understanding of these adhesion mechanisms has resulted from technological advances in our ability to grow endothelial cells as monolayers and the production of monoclonal antibodies that bind to and inhibit the function of adhesion molecules on the surface of leukocytes and endothelial cells. While the information gained from studying the expression of adhesion molecules in vitro has improved our understanding of the mechanisms that mediate the expression of cell adhesion molecules in inflamed tissue, there is a concern that monolayers of cultured endothelial cell may not adequately simulate the in vivo situation.

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Authors
  1. M. J. Eppihimer
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  2. D. N. Granger
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1997 Springer-Verlag Berlin Heidelberg

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Eppihimer, M.J., Granger, D.N. (1997). Endothelial Cell Adhesion Molecule Expression in Acutely Inflamed Tissues. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1997. Yearbook of Intensive Care and Emergency Medicine, vol 1997. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-13450-4_5

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  • DOI: https://doi.org/10.1007/978-3-662-13450-4_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-13452-8

  • Online ISBN: 978-3-662-13450-4

  • eBook Packages: Springer Book Archive

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