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Neuronal Abnormalities in Crohn’s Disease: Greater Density and Altered Morphology of Nerves Containing Derivatives of Pro-PHM/VIP

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Progress in Surgical Pathology

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Abstract

NEUROMATOUS HYPERPLASIA HAS BEEN known to occur in inflammatory bowel disease of regional ileitis or Crohn’s disease.1,2,3 Subsequent immunochemical studies have established that the apparent hyperplasia of nerves in bowel affected by this disease is due largely to an abnormal population of vasoactive intestinal polypeptide (VIP)-containing nerves. In affected and histologically unaffected areas of bowel, VIP nerves are seen in greater density than normal and show distinct morphological abnormalities, including linear distortion and thickening.4,5 However, there has been some degree of controversy over certain aspects of these neuronal changes.

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References

  1. Davis DR, Dockerty MB, Mayo CW: The myenteric plexus in regional ileitis: a study of ganglion cells in the ileum in 24 cases. Surg Gynaecol 101:208–211, 1955.

    CAS  Google Scholar 

  2. Morson BC, Dawson IMP: Inflammatory disorders, In: Gastrointestinal Pathology. Morson BC, Dawson IMP (eds). Oxford, Blackwell Scientific Press, 243–298, 1972.

    Google Scholar 

  3. Whitehead R: Pathology of Crohn’s disease of the colon, In: Kirsner JB, Shorter ZG (eds): Inflammatory Bowel Disease. Philadelphia; W.B. Saunders, 182–198, 1975.

    Google Scholar 

  4. Bishop AE, Polak JM, Bryant MG, et al: Abnormalities of vasoactive intestinal polypeptide-containing nerves in Crohn’s disease. Gastroenterol 79:853–860, 1980.

    CAS  Google Scholar 

  5. O’Morain C, Bishop AE, McGregor GP, et al: Vasoactive intestinal peptide concentrations and immunocytochemical studies in rectal biopsies from patients with inflammatory bowel disease. Gut 25:57–61, 1984.

    Article  PubMed  Google Scholar 

  6. Schmitz-Reinhardt B, Lohse AW, Arnold R: VIP tissue content in colonic biopsies from normal patients compared with Crohn’s disease and ulcerative colitis. Reg Pep Suppl 3:540, 1985.

    Google Scholar 

  7. Spaepen M, Van Gompel A, Bormans V, et al: Vasoactive intestinal polypeptide (VIP), somatostatin and substance P concentrations in colonic biopsies from patients with Crohn’s disease. Dig Dis Sci 8:825, 1984.

    Google Scholar 

  8. Sjolund K, Schaffalitzky de Muckadell OB, Fahrenkrug J, et al: Peptide-containing nerve fibres in the gut wall in Crohn’s disease. Gut 24:724–733, 1983.

    Article  PubMed  CAS  Google Scholar 

  9. Bishop AE, Carlei F, Lee V, et al: Combined immunostaining of neurofilaments, neuron specific enolase, GFAP and S-100. Histochem 82:93–97, 1985.

    Article  CAS  Google Scholar 

  10. Bishop AE, Polak JM, Facer P, et al: Neuron specific enolase: a common marker for endocrine cells and innervation of the gut and pancreas. Gastroenterology 83:902–912, 1982.

    PubMed  CAS  Google Scholar 

  11. Schmechel D, Marangos PJ, Brightman M: Neuron specific enolase is a molecular marker for peripheral and central neuroendocrine cells. Nature 276:834–836, 1978.

    Article  PubMed  CAS  Google Scholar 

  12. Dahl D, Bignami A: Preparation of antisera to neurofilament protein from chicken brain and human sciatic nerve. J Comp Neurol 176:645–658, 1977.

    Article  PubMed  CAS  Google Scholar 

  13. Hickey WF, Lee V, Trojanowski JQ, et al: Immu-nohistochemical application of monoclonal antibodies against myelin basic protein and neurofilament triplet protein subunits. J Histochem Cytochem 31:1126–1135, 1983.

    Article  PubMed  CAS  Google Scholar 

  14. Moore BW: Chemistry and biology of two proteins, S-100 and 14–3–2, specific to the nervous system. Int Rev Neurobiol 15:215–225, 1972.

    Article  PubMed  CAS  Google Scholar 

  15. Jessen KR, Mirsky R: Glial cells in the enteric nervous system contain glial fibrillary acidic protein. Nature 286:736–737, 1980.

    Article  PubMed  CAS  Google Scholar 

  16. Bloom SR, Christofides ND, Delamarter J et al: Tumour co-production of VIP and PHI explained by single coding gene. Lancet 2:1163–1165, 1983.

    Article  PubMed  CAS  Google Scholar 

  17. Itoh N, Obata K, Yanaihara N, et al: Human pre-provasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature 304:547–549, 1983.

    Article  PubMed  CAS  Google Scholar 

  18. Clague JR, Sternini C, Brecha NC: Localisation of calcitonin gene-related peptide-like immunoreactivity in neurons of the rat gastrointestinal tract. Neurosci Lett 56:63–68, 1985.

    Article  PubMed  CAS  Google Scholar 

  19. Rodrigo J, Polak JM, Fernandez L, et al: Calcitonin gene-related peptide immunoreactive sensory and motor nerves of the rat, cat and monkey oesophagus. Gastroenterology 88:444–451, 1985.

    PubMed  CAS  Google Scholar 

  20. Rosenfeld MG, Mermod JJ, Amara SG, et al: Production of a novel neuropeptide encoded by the calcitonin gene via tissue specific RNA processing. Nature 304:129–135, 1983.

    Article  PubMed  CAS  Google Scholar 

  21. Ekblad E, Ekelund M, Graflùer M, et al: Peptide-containing nerve fibres in the stomach wall of rat and mouse. Gastroenterology 89:73–85, 1985.

    PubMed  CAS  Google Scholar 

  22. Ferri GL, Ali-Rachedi, Tatemoto K, et al: Immunocytochemical localisation of neuropeptide Y-like immunoreactivity in extrinsic noradrenergic and intrinsic gut neurons. Front Horm Res 12:81–84, 1984.

    Google Scholar 

  23. Sundler F, Moghimzadeh E, Hakanson R, et al: Nerve fibres in the gut and pancreas of the rat displaying neuropeptide Y immunoreactivity. Intrinsic and extrinsic origin. Cell Tiss Res 230:487–493, 1983.

    Article  CAS  Google Scholar 

  24. Tatemoto K, Carlqvist M, Mutt V: Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature 296:659–660, 1982.

    Article  PubMed  CAS  Google Scholar 

  25. Bishop AE, Polak JM, Bauer FE, et al: The occurrence and distribution of a newly discovered regulatory peptide, galanin, in the human, porcine and rodent enteric nervous system. Gut 27:849–857, 1986.

    Article  PubMed  CAS  Google Scholar 

  26. Rokaeus A, Melander T, Hökfelt T, et al: A galanin-like peptide in the central nervous system and intestine of rat. Neurosci Lett 59:161–166, 1984.

    Article  Google Scholar 

  27. Tatemoto K, Rokaeus A, Jornvall H, et al: Galanin—a novel biologically active peptide from porcine intestine. FEBS Lett 164:124–128, 1983.

    Article  PubMed  CAS  Google Scholar 

  28. Bishop AE, Polak JM, Bloom SR, et al: A new universal technique for the immunocytochemical localisation of peptidergic innervation. J Endocrinol 77:25–26, 1978.

    Article  Google Scholar 

  29. Huang WM, Gibson SJ, Facer P, et al: Improved section adhesion for immunocytochemistry using high molecular weight polymers of L-lysine as a slide coating. Histochem 77:275–279, 1983.

    Article  CAS  Google Scholar 

  30. Coons AH, Leduc HH, Connolly JM: Studies on antibody production. J Exp Med 102:49–60, 1955.

    Article  PubMed  CAS  Google Scholar 

  31. Bishop AE, Polak, JM, Yiangou Y, et al: The distribution of PHI and VIP in porcine gut and their co-localisation to a proportion of intrinsic ganglion cells. Peptides 5:255–259, 1984.

    Article  PubMed  CAS  Google Scholar 

  32. Yiangou Y, Christofides ND, Blank MA, et al: Molecular forms of peptide histidine isoleucine-like immunoreactivity in the gastrointestinal tract. Gastroenterology 89:516–524, 1985.

    PubMed  CAS  Google Scholar 

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Authors
  1. A. E. Bishop
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  2. R. Pietroletti
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  3. C. W. Taat
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  4. W. H. Brummelkamp
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  5. S. R. Bloom
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  6. J. M. Polak
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Editor information

Editors and Affiliations

  1. University of New Mexico, New Mexico, USA

    Cecilia M. Fenoglio-Preiser M.D. (Professor of Pathology, Director of Laboratory Services) (Professor of Pathology, Director of Laboratory Services)

  2. Albuquerque Veterans Administration Medical Center, Albuquerque, New Mexico, USA

    Cecilia M. Fenoglio-Preiser M.D. (Professor of Pathology, Director of Laboratory Services) (Professor of Pathology, Director of Laboratory Services)

  3. Department of Pathology, Columbia University College of Physicians and Surgeons, Memorial Hospital, Morristown, New Jersey, USA

    Marianne Wolff M.D. (Professor of Clinical Surgical Pathology) (Professor of Clinical Surgical Pathology)

  4. National Cancer Institute, Milan, Italy

    Franco Rilke M. D. (Deputy Director, Director, Professor) (Deputy Director, Director, Professor)

  5. Division of Pathology, Postgraduate School of Anatomic Pathology, University of Pavia, Italy

    Franco Rilke M. D. (Deputy Director, Director, Professor) (Deputy Director, Director, Professor)

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© 1989 Springer-Verlag Berlin Heidelberg

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Bishop, A.E., Pietroletti, R., Taat, C.W., Brummelkamp, W.H., Bloom, S.R., Polak, J.M. (1989). Neuronal Abnormalities in Crohn’s Disease: Greater Density and Altered Morphology of Nerves Containing Derivatives of Pro-PHM/VIP. In: Fenoglio-Preiser, C.M., Wolff, M., Rilke, F. (eds) Progress in Surgical Pathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12814-5_4

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  • DOI: https://doi.org/10.1007/978-3-662-12814-5_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-12816-9

  • Online ISBN: 978-3-662-12814-5

  • eBook Packages: Springer Book Archive

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