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Ultrastructural and Immunohistochemical Modulations of Malignant Peripheral Nerve Tumors

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Progress in Surgical Pathology

Abstract

Seventeen cases of malignant peripheral nerve tumors were investigated by electron microscopy and immunohistochemistry. Three had histopathological, histochemical, and ultrastructural features consistent with the diagnosis of neuroepithelioma, and 6 had malignant schwannoma. Seven poorly differentiated small cell tumors were tentatively classified according to histopathology as either Ewing’s sarcoma (2 cases), or undifferentiated small cell tumors (3 cases), liposarcoma (1 case), and extraskeletal chondrosarcoma (1 case), which showed neuroepithelial ultrastructural and histochemical markers such as dense core granules and positive reactivity for neuron-specific enolase (6 cases), S-100 protein (2 cases), and neurofilaments (3 cases) and with the antibody Leu 7 (2 cases). Five of these 7 poorly differentiated small cell tumors, which also showed schwannian features, may represent intermediate forms that link primitive peripheral neuroectodermal tumors to malignant schwannomas.

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Authors
  1. Luciano Lombardi
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  2. Serenella Cerasoli
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  3. Giorgio Cattoretti
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  4. Silvana Pilotti
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Editor information

Editors and Affiliations

  1. University of New Mexico, Albuquerque, New Mexico, USA

    Cecilia M. Fenoglio-Preiser M.D. (Professor of Pathology, Director of Laboratory Services) (Professor of Pathology, Director of Laboratory Services)

  2. Albuquerque Veterans Administration Medical Center, Albuquerque, New Mexico, USA

    Cecilia M. Fenoglio-Preiser M.D. (Professor of Pathology, Director of Laboratory Services) (Professor of Pathology, Director of Laboratory Services)

  3. Columbia University College of Physicians and Surgeons, Morristown, New Jersey, USA

    Marianne Wolff M.D. (Professor of Clinical Surgical Pathology) (Professor of Clinical Surgical Pathology)

  4. Department of Pathology, Memorial Hospital, Morristown, New Jersey, USA

    Marianne Wolff M.D. (Professor of Clinical Surgical Pathology) (Professor of Clinical Surgical Pathology)

  5. National Cancer Institute, Milan, Italy

    Franco Rilke M.D. (Deputy Director, Director, Professor) (Deputy Director, Director, Professor)

  6. Division of Pathology, Italy

    Franco Rilke M.D. (Deputy Director, Director, Professor) (Deputy Director, Director, Professor)

  7. Postgraduate School of Anatomic Pathology, University of Pavia, Italy

    Franco Rilke M.D. (Deputy Director, Director, Professor) (Deputy Director, Director, Professor)

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© 1990 Springer-Verlag Berlin Heidelberg

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Lombardi, L., Cerasoli, S., Cattoretti, G., Pilotti, S. (1990). Ultrastructural and Immunohistochemical Modulations of Malignant Peripheral Nerve Tumors. In: Fenoglio-Preiser, C.M., Wolff, M., Rilke, F. (eds) Progress in Surgical Pathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12811-4_11

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  • DOI: https://doi.org/10.1007/978-3-662-12811-4_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-12813-8

  • Online ISBN: 978-3-662-12811-4

  • eBook Packages: Springer Book Archive

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