Zusammenfassung
Das Immunsystem hat die Aufgabe, seinen Wirtsorganismus vor Infektionen zu schützen. Dafür muß das Immunsystem eine fast unbegrenzte Zahl von fremden Antigenen erkennen und gegen sie reagieren können, dieses Erkennen und/oder Reagieren darf aber nicht gegen körpereigene Antigene gerichtet sein. Die Diskriminierung zwischen Selbst- und Nichtselbstantigenen ist eine grundlegende Eigenschaft des Immunsystems. Die fehlende Reaktion des Immunsystems auf Selbstantigene ist als Selbsttoleranz definiert, der Verlust dieser Toleranz führt zur Autoimmunität, die dadurch verursachten Erkrankungen werden Autoimmunkrankheiten genannt.
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Dannecker, G. et al. (2001). Autoimmunkrankheiten. In: Lentze, M.J., Schaub, J., Schulte, F.J., Spranger, J. (eds) Pädiatrie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12660-8_12
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