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Nitrate und Nitrattoleranz in der Behandlung der koronaren Herzerkrankung pp 115–131Cite as

Zur Frage der Toleranzentwicklung während einer Langzeitbehandlung mit Isosorbiddinitrat bei Patienten mit koronarer Herzkrankheit

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Zusammenfassung

Die älteste Mitteilung über eine Toleranz stammt aus dem Jahre 1888 von Stewart (32, 33). Er beschrieb einen Fall, bei dem er eine 2000fach höhere Dosis Nitroglycerin benötigte, um den gleichen Effekt zu erzielen wie bei der ersten Verabfolgung der Substanz. In der Folgezeit wurden wiederholt Berichte über ein Nachlassen des Effektes von Nitraten unter chronischer Therapie an den Parametern Pulsfrequenz, Blutdruck und Kopfschmerz (5, 11, 12, 30, 35) bekannt. Andererseits wurden aber auch Entzugsphänomene nach längerem Gebrauch von Nitraten beschrieben (15, 27).

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Author information

Authors and Affiliations

  1. Medizinische Klinik I, Stadtkrankenhaus Hanau, Leimenstr. 20, D-6450, Hanau 1, Deutschland

    Prof. Dr. H.-J. Becker

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  1. Prof. Dr. H.-J. Becker
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  2. R. Meudt
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  3. S. Kretschmer
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  4. H. D. Hüwer
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Editor information

Editors and Affiliations

  1. Abteilung für Kardiologie, Zentrum Innere Medizin, Theodor-Stern-Kai 7, D-6000, Frankfurt/Main 70, Deutschland

    G. Kober  & M. Kaltenbach  & 

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© 1983 Springer-Verlag Berlin Heidelberg

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Becker, HJ., Meudt, R., Kretschmer, S., Hüwer, H.D. (1983). Zur Frage der Toleranzentwicklung während einer Langzeitbehandlung mit Isosorbiddinitrat bei Patienten mit koronarer Herzkrankheit. In: Kober, G., Kaltenbach, M. (eds) Nitrate und Nitrattoleranz in der Behandlung der koronaren Herzerkrankung. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-12598-4_12

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  • DOI: https://doi.org/10.1007/978-3-662-12598-4_12

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-662-12599-1

  • Online ISBN: 978-3-662-12598-4

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