Skip to main content

Chemotherapie und Hyperthermie

  • Chapter
Kompendium Internistische Onkologie
  • 11 Accesses

Zusammenfassung

Der klinische Einsatz einer Thermochemotherapie, d. h. Hyperthermie in Kombination mit Chemotherapie, findet zunehmend Eingang in ein interdisziplinäres onkologisches Behandlungskonzept. Neben einer direkten zytotoxischen Wirkung der Hyperthermie besteht im hyperthermierten Tumorgewebe zusätzlich ein chemosensibilisierender Effekt. Neuere experimentelle Ergebnisse deuten darauf hin, daß durch Hyperthermie eine Änderung der antigenen Eigenschaften von Tumorzellen induziert wird.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Amichetti M, Graiff C, Felin G, Pani G, Bolner A, Maluta S, Valdagni R (1993) Cisplatin hyperthermia and radiation (trimodal therapy) in patients with locally advanced head and neck tumors: A phase I-II study. Int J Radiat Oncol Biol Phys 26: 801–807

    Google Scholar 

  • Armour EP, McEachern D, Wang Z, Corry PM, Martinez A (1993) Sensitivity of human cells to mild hyperthermia. Cancer Res 53: 2740–2744

    PubMed  CAS  Google Scholar 

  • Bornstein BA, Zouranjian PS, Hansen JL, Fraser SM, Gelwan LA, Teicher BA, Svensson GK (1992) Local hyperthermia radiation therapy and chemotherapy in patients with local-regional recurrence of breast carcinoma. Int J Radiat Oncol Biol Phys 25: 79–85

    Article  Google Scholar 

  • Davis RK, Gibbs FA, Sapozink D, Farver M, Harker G (1990) Thermochemotherapy in inoperable head and neck cancer. Otolaryngol Head Neck Surg 103: 897901

    Google Scholar 

  • Dewey WC (1994) Arrhenius relationships from the molecule and cell to the clinic. Int J Hyperthermia 10: 457–483

    Article  PubMed  CAS  Google Scholar 

  • Egawa S, Tsukiyama I, Akine Y, Kajiura Y, Ogino T, Yamashita K (1988) Hyperthermic therapy of deep seated tumors: comparison of the heating efficiencies of an annular array applicator and a capacitively coupled radiofrequency system. Int J Radiat Oncol Biol Phys 14: 521–528

    Article  PubMed  CAS  Google Scholar 

  • Feldmann HJ, Sack H (1993) Strahlentherapie in Kombination mit regionaler Hyperthermie bei lokal fortgeschrittenen Beckentumoren. Med Tech 4: 9–15

    Google Scholar 

  • Fuller KJ, Issels RD, Slosman DO, Guillet JG, Soussi T, Polla BS (1994) Cancer and the Heat Shock Response. Eur J Cancer 30: 1884–1891

    Article  Google Scholar 

  • Hahn GM (1982) Hyperthermia and cancer. Plenum Press, New York London

    Book  Google Scholar 

  • Hamazoe R, Murakami A, Hiraoka Y, Maeta M, Kaibara N (1991) A phase II pilot study of the combined application of hyperthermia and intra-hepatoarterial chemotherapy using cisplatinum and 5-fluorouracil. J Surg Oncol 48: 127–132

    Article  PubMed  CAS  Google Scholar 

  • Hand JW, James RJ (1986) Physical techniques in clinical hyperthermia. Research Studies Press, Letchworth, pp 98–140

    Google Scholar 

  • Issels RD, Prenninger S, Nagele A et al. (1990) Ifosfamide plus etoposide combined with regional hyperthermia in patients with locally advanced sarcomas: A phase II study. J Clin Oncol 11: 1818–1829

    Google Scholar 

  • Issels RD, Mittermüller J, Gerl A et al. (1991) Improvement of local control by regional hyperthermia combined with systemic chemotherapy (ifosfamide plus etoposide) in advanced sarcomas: updated report on 65 patients. J Cancer Res Clin Oncol 117: 141–147

    Article  Google Scholar 

  • Issels RD, Rahman S, Pihusch R et al. (1995) Neoadjuvant systemic chemotherapy combined with regional hyperthermia in advanced or recurrent soft tissue sarcoma: Results of the RHT-91 study. Fifth Int Congr on Anti-Cancer Chemotherapy, Paris

    Google Scholar 

  • Kakehi M, Ueda K, Mukojima T, Hiraoka M, Seto O, Akanuma A, Nakatsugawa S (1990) Multi-institutional clinical studies on hyperthermia combined with radiotherapy or chemotherapy in advanced cancer of deep-seated organs. Int J Hyperthermia 6: 719–740

    Article  PubMed  CAS  Google Scholar 

  • Leopold KA, Oleson JR, Clarke-Pearson D et al. (1993) Intraperitoneal cisplatin and regional hyperthermia for ovarian carcinoma. Int J Radiat Oncol Biol Phys 27: 1245–1251

    Article  PubMed  CAS  Google Scholar 

  • Matsuda H, Baba K, Kitamura K, Toh Y, Ikeda Y, Sugimachi K (1993) Hyperthermo-chemo-radiotherapy for patients with early carcinoma of the esophagus. Hepatogastroenterology 40: 217–221

    PubMed  CAS  Google Scholar 

  • Multhoff G, Botzler C, Wiesnet M, Müller E, Meier T, Wilmanns W, Issels RD (1995) A stress-inducible 72 kDa heat shock protein (HSP 72) is expressed on the cell surface of human tumor cells, but not on normal cells. Int J Cancer 61: 1–8

    Article  Google Scholar 

  • Multhoff G, Botzler C, Wiesnet M, Eissner G, Issels RD (1995) CD3 negative large granular lymphocytes recognize a heat inducible immunogenic determinant associated with the 72 KD heat shock protein (HSP 72) on human sarcoma cells. Blood

    Google Scholar 

  • Oleson JR, Sim DA, Conrad J, Fletcher AM, Gross EJ (1986) Results of a phase I regional hyperthermia device evaluation: microwave annular array versus radiofrequency induction coil. Int J Hyperthermia 2: 327–336

    Article  PubMed  CAS  Google Scholar 

  • Overgaard J, Gonzales DG, Hulshof MCCM, Arcangeli G, Dahl O, Mella O, Bentzen SM (1995) Hyperthermia as an adjuvant to radiation therapy of recurrent or metastatic melanoma. A multi-centre randomized trial by the European Society for Hyperthermic Oncology. Lancet

    Google Scholar 

  • Rietbroek RD (1994) Hyperthermia in combination with chemotherapy: a new perspective. Eur Cancer 2: 6–8

    Google Scholar 

  • Rigatti P, Lev A, Colombo R (1991) Combined Intravesical Chemotherapy with Mitomycin C and Local Bladder Microwave-Induced Hyperthermia as a Preoperative Therapy for Superficial Bladder Tumors. Eur Urol 20: 204–210

    PubMed  CAS  Google Scholar 

  • Robins HI, Cohen JD, Schmitt CL et al. (1993) Phase I clinical trial of carboplatin and 41.8°C whole body hyperthermia in cancer patients. J Clin Oncol 11: 1787–1794

    PubMed  CAS  Google Scholar 

  • Romanowski R, Schött C, Issels RD et al. (1993) Regionale Hyperthermie mit systemischer Chemotherapie bei Kindern and Jugendlichen: Durchführbarkeit and klinische Verläufe bei 34 intensiv vorbehandelten Patienten mit prognostisch ungünstigen Tumorerkrankungen. Klin Pädiatr 205: 249–256

    Article  PubMed  CAS  Google Scholar 

  • Shimm DS, Hynynen KH, Anhalt DP, Roemer RB, Cassady JR (1988) Scanned focussed ultrasound hyperthermia: initial clinical results. Int J Radiat Oncol Biol Phys 15: 1203–1208

    Article  PubMed  CAS  Google Scholar 

  • Srivastava PK (1993) Peptide-binding heat shock proteins in the endoplasmic reticulum: role in immune response to cancer and in antigen presentation. Advance Cancer Res 62: 153

    Article  PubMed  CAS  Google Scholar 

  • Turner PF (1984) Regional hyperthermia with an annular phased array. IEEE Trans Biomed Eng 31: 106–115

    Article  PubMed  CAS  Google Scholar 

  • Udono H, Srivastava PK (1993) Heat shock protein 70-associates peptides elicit specific cancer immunity. J Exp Med 178: 1391–1396

    Article  PubMed  CAS  Google Scholar 

  • Wiedemann GJ, Siemens HJ, Weiss C, Wagner T (1993) Effects of temperature on the therapeutic efficacy and pharmacokinetics of ifosfamide. Cancer Res 53: 4268–4272

    PubMed  CAS  Google Scholar 

  • Wiedemann GJ, d’Oleire F, Knop E et al. (1994) Ifosfamide and carboplatin combined with 41.8°C whole-body hyperthermia in patients with refractory sarcoma and malignant teratoma. Cancer Res 54: 5346–5350

    PubMed  CAS  Google Scholar 

  • Wiedemann GJ, Gutsche M, Mentzel M et al. (1995) Ifosamide Carboplatin and etoposide combined with 41.8°C whole-body hyperthermia in patients with refractory cancer. Cancer Res 55

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Issels, R.D. (1997). Chemotherapie und Hyperthermie. In: Schmoll, HJ., Höffken, K., Possinger, K. (eds) Kompendium Internistische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12175-7_103

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-12175-7_103

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-60830-1

  • Online ISBN: 978-3-662-12175-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics