The Relation of Histamine to Inflammation

  • P. Stern
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 18 / 1)


Inflammation is a complex process involving many biochemical changes with the participation of several mediators (Menkin, 1956; Rajka, 1959; Ungar, 1952). Meier (1959) and Meier et al. (1956) have recently discussed the biochemistry of the inflammatory process and its causal connections in an excellent review. Since a number of factors should be considered, it is difficult to speak of the role of a single mediator in the development of inflammation. It has been demonstrated that histamine plays an important role, but its action could not account for the whole set of events (Haas, 1951; Feldberg, 1954; Rocha E Silva, 1955). Yet, thanks to the availability of histamine liberators we may at present discern the part played by histamine better than in the past. The function of any naturally occurring agent can be better recognized by eliminating it from the organism in order to gain insight into its real physiological tasks. This method has rendered excellent service in the fields of vitamins and hormones where it has long been in use. Feldberg (1956) reviewing the mediators participating in the development of the inflammatory processes stated: “Nowadays we have the possibility of depleting a tissue of its histamine. Unfortunately this has so far been achieved only in some species and in some tissues, but by comparing, as Zweifach has done, the inflammatory vascular reaction in a normal and in a histamine-depleted tissue, we might perhaps obtain more precise information about the role of released histamine in the histamine-like vascular reactions of inflammation.”


Inflammatory Process Histamine Level Tuberculin Reaction Connective Tissue Element Healing Tendency 
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  1. Bunn, O., and TR. Wagner-Jauregg: Zur Problematik antiphlogistischer Teste. Arzneimittel-Forsch. 10, 834–836 (1960).Google Scholar
  2. Ciglar, M.: Über die Freisetzung histaminartiger Stoffe durch kutane Verabreichung eines Autolysates aus aeroben Erdbazillen (B. subtilis und B. megatherium). Z. Rheumaforsch. 17, 2–7 (1958).Google Scholar
  3. Ignjacev, A. Misirlija, A. Nikulin and P. Stern: Beitrag zur Wirkungsweise des Kalziums im EntzündungsprozeB. Arch. int. Pharmacodyn. 113, 360–366 (1958)Google Scholar
  4. Feldberg, W.: On some physiological aspects of histamine. J. Pharm. Pharmacol. 6, 281–301 (1954).PubMedCrossRefGoogle Scholar
  5. Feldberg, W.: The role of mediators in the inflammatory tissue response. Int. Arch. Allergy 8, 15–31 (1956).PubMedCrossRefGoogle Scholar
  6. Feldberg, W., and A. A. Loeser: Histamine content of human skin in different clinical disorders. J. Physiol. (Lond.) 126, 286–292 (1954).Google Scholar
  7. Feldberg, W., and A. A. Miles: Regional variations of increased permeability of skin capillaries induced by a histamine liberator and their relation to the histamine content of the skin. J. Physiol. (Loud.) 120, 205–213 (1953).Google Scholar
  8. Ferluga, J., A. Nikulin and P. Stern: Die antiphlogistische Wirkung der Epsilon-AminoKapronsäure. Allergie u. Asthma 9, 18–22 (1963).Google Scholar
  9. Frrmmer, M.: Beeinflussung der Durchlässigkeit von Blut-Capillaren der Kaninchenhaut für Makromoleküle durch biogene gefäßaktive Substanzen. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 242, 390–402 (1961).Google Scholar
  10. Haas, H.: Histamin und Antihistaminica, I—II. Aulendorf: Verl. Cantor 1951Google Scholar
  11. Haitinger, M.: Fluorescenz-Mikroskopie. Leipzig 1938.Google Scholar
  12. Huxovi, S., I P. Stern: KoliUna histamina u tkivima pod utjecajem arsen-trioksida. Acta med. iugosl. 16, 43–50 (1962).Google Scholar
  13. Ignjacev, A. Nirulin, P. Stern, A. Misirlija U. M. Ciglar: Hypothyreoidismus und entzündliche Reaktion. Acta endocr. (Kbh.) 23, 426–432 (1956).PubMedGoogle Scholar
  14. Iring, S.: Granuloma pouch and skin histamine. Acta med. Okayama 12, 112–125 (1958)Google Scholar
  15. Jaques, R.: Das Thalassinödem der Ratte und seine Beeinflussung durch verschiedene Pharmaka. Helv. physiol. pharmacol. Acta 11, C55–057 (1953).Google Scholar
  16. Kramer, M.: Zur antiphlogistischen Wirkung des Histaminliberators 48/80, einiger Antihistaminica und einiger Antirheumatica. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 233, 125–133 (1958).Google Scholar
  17. Lewis, G.: 5-Hydroxytryptamine. New York — London — Paris — Los Angeles: Pergamon Press 1958.Google Scholar
  18. Meier, R.: Biochemische Kausalzusammenhänge des Entzündungsvorgangs. In: Medizinische Grundlagenforschung, Band II ( Bauer, K. FR., Ed.). Stuttgart: G. Thieme Verlag 1959.Google Scholar
  19. Meier, R., P. Desaulles and B Seaär: Analyse der biochemischen Ursachen der entzündlichen Zellreaktion. Verh. Naturf. Ges. (Basel) 67, 447–478 (1956).Google Scholar
  20. Menkin, V.: Biochemical Mechanisms in Inflammation. Springfield, Ill.: Charles C. Thomas Publ. 1956.Google Scholar
  21. Misirlija, A., P. Stern i S. Hukovie: Znacenje histamina i nervnog sistema za tuberkulinsku reakciju. Tuberkuloza 8, 102–105 (1956).PubMedGoogle Scholar
  22. Nixulin, A., J. Ferluga i P. Stern: Uticaj kolicine tkivnog histamina na tok upalnog procesa. Acta med. iugosl. 16, 182–188 (1962).Google Scholar
  23. Paton, W. D. M.: The Release of Histamine. Progress in Allergy 5, 79–148.Google Scholar
  24. Raab, W.: Die Beeinflussung des experimentellen Dinitrochlorbenzolekzems des Meerschwein-chens durch den Histaminliberator 48/80. Arch. kiln exp. Derm. 214, 307–318 (1962)Google Scholar
  25. Rajka, E.: Allergie und allergische Erkrankungen. Bd. I, Allgemeiner Teil. Budapest: Akadémia Kadó 1959.Google Scholar
  26. Rochae Silva, M.: Histamine: Its Role in Anaphylaxis and Allergy. Springfield, Ill.: Charles C. Thomas, Publ. 1955.Google Scholar
  27. Rochae Silva, M.: Biochemistry and Pharmacology of Bradykinin In: Polypeptides. Oxford-London-New York-Paris: Pergamon Press 1960.Google Scholar
  28. Rosenthai, S. R., and D. Minard: Experiments on histamine as the chemical mediator for cutaneous pain. J. exp. Med. 70, 415–425 (1939).CrossRefGoogle Scholar
  29. Sandberg, N.: Accelerated collagen formation and histamine. Nature (Lond.) 194, 183 (1962)CrossRefGoogle Scholar
  30. Selye, H.: Use of “granuloma pouch” technique in the study of antiphlogistic corticoids. Proc. Soc. exp. Biol. (N. Y.) 82, 328–333 (1953)Google Scholar
  31. Sherry, S., A. P. Fletcher, Norma Alkjaersig, and W. D. Sawyer: s-aminocaproic acid “a potent anti-fibrinolytic agent”. Trans. Ass. Amer. Phycns. 72, 62–70 (1959)Google Scholar
  32. Speckmann, K.: Histamin als Regulator nervös gesteuerter Abwehrgänge in der Peripherie. Verh. Deutsch. Ges. innere Med., 59. Kongr. München: Verl. J. F. Bergmann 1953Google Scholar
  33. Stern, P.: Antiallergische Wirkung der Azulene. 1st Internat. Congr. for Allergy, Zürich. Basel-New York: S. Karger 1951.Google Scholar
  34. Stern, P.: Die Bedeutung des Histamins in der Entstehung des Ekzems. Arch. int. Pharmacodyn. 105, 279–284 (1956).Google Scholar
  35. Stern, P.: Studies in animals on the effect of subtivaccin, an autolysate from B. Subtilis and B. Megatherium, on the permeability of inflammatory tissues and on that of the central nervous system. Acta physiol. pharmacol. neerl. 8, 457–465 (1959).PubMedGoogle Scholar
  36. Stern, P., and S. Huxovi: Die Rolle des Histamins in der Übertragung des Schmerzempfindens Arch. in Pharmacodyn. 108, 273–278 (1956).Google Scholar
  37. Stern, P., and R. Milin: Die antiallergische und antiphlogistische Wirkung der Azulene. Arzneimittel-Forsch. 6, 445–450 (1956).Google Scholar
  38. Stern, P., and A. Nikulin: Über die entzündungshemmende Wirkung der Azulene. Ärztl. Forsch. 11, I/495–I/498 (1957).Google Scholar
  39. Stern, P., A. Nikulin, and J. Ferluga: The role of histamine and bradykinin in the inflammatory process. Arch. in Pharmacodyn. 140, 528–538 (1962).Google Scholar
  40. Stern, P., A. Nikulin, A. Misirlija u. M. Ciglar: Histamin im Entzündungsprozeß. Naunyn-Schmiedebergs Arch. exp. Path. Pharmakol. 227, 522–527 (1956).Google Scholar
  41. Stern, P., U. Edita Gmaz-Nikulin: 5-Hydroxytryptamin und Histamin im EntzündungsprozeB. Int. Arch. Allergy 16, 157–162 (1960).PubMedCrossRefGoogle Scholar
  42. Ungar, G.: Inflammation and its control. A biochemical approach. Lancet 1952 2, 742PubMedCrossRefGoogle Scholar
  43. Wilhelm, D. L.: The mediation of increased vascular permeability in inflammation. Pharmacol. Rev. 14, 251–280 (1962).PubMedGoogle Scholar
  44. Zweifach, B. W.: Symposium on the Mechanism of Inflammation. Montreal: Ed. G. Jasmin and A. Robert. Acta Inc. 1953.Google Scholar
  45. Zweifach, B. W.: cited from Feldberg (1956).Google Scholar

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© Springer-Verlag Berlin Heidelberg 1966

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  • P. Stern

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