Physiological Significance of the Effect of Histamine on Gastric Secretion

  • A. C. Ivy
  • W. H. Bachrach
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 18 / 1)


Histamine stimulates the gastric secretion of acid and in blood concentrations below the threshold for other physiological responses. Furthermore, histamine is especially concentrated in the gastric and intestinal mucosa. The gastric mucosa of man and carnivora is devoid of the enzyme, histaminase, which inactivates histamine. The gastric juice contains histamine, the amount apparently being proportional to the output of HCl. These four observations, generally considered to be well-established, render it logical to investigate the theory that the release of histamine by the gastric mucosa might be the or a physiological, circulating or local hormone involved in the gastric secretion of HCl.


Gastric Mucosa Parietal Cell Gastric Secretion Vagal Stimulation Histamine Content 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1966

Authors and Affiliations

  • A. C. Ivy
  • W. H. Bachrach

There are no affiliations available

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