Release of Histamine by Animal Venoms and Bacterial Toxins

  • W. T. Beraldo
  • W. Dias da Silva
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 18 / 1)


The problem of release of histamine by animal venoms and bacterial toxins was born out from earlier experiments described by Bruce (1910) in which he claimed that the reddening and swelling that follow the instillation of mustard oil into the conjunctival sac of the rabbit are dependent upon the integrity of the conjunctival nerves. Stevenson and Reid (1915) repeated Bruce’s experiments and could not reproduce his findings. Groll (1922), Hirschfelder (1924), Nakamura and Takahashi (1924), Tannenberg and Degener (1925), Hanzlik (1926), Tainter and Reichert (1928) using several local anesthetics were unanimous in their findings that the chemosis produced by mustard oil in the anesthetized eye is not appreciably different from the opposite non-anesthetized control.


Mast Cell Histamine Release Snake Venom Anaphylactic Shock Ascaris Lumbricoides 
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© Springer-Verlag Berlin Heidelberg 1966

Authors and Affiliations

  • W. T. Beraldo
  • W. Dias da Silva

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