Effect of Histamine on Gastric Secretion

  • A. C. Ivy
  • W. H. Bachrach
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 18 / 1)


The powerful effect of histamine as a stimulant of gastric secretion was discovered by Popielski and by Keeton, Luckhardt and Koch in 1919–1920 in experiments on dogs. A similar action in humans was demonstrated (Carnot et al., 1922) soon thereafter, and it was subsequently shown that histamine stimulates gastric secretion in all species adequately tested, including the groundhog (Marmota monax) (Friedman and Armour, 1936), the rhesus monkey (Schnedorf and Ivy, 1937), the pigeon (Friedman, 1939; Ojha, 1960), the chicken (Friedman, 1939), the cat (Bjorkman et al., 1943), the mouse (Davenport and Chavre, 1950), the tortoise (testudo graeca) (Wright and Trethewie, 1956), the lizard (teliqua nigrolutea and tachysaurus rugosus) (Davenport and Chavre, 1950), the rat (Kyle and Welbourn, 1956; Lane, 1957), the guinea pig (Marks, 1957), and the wild boar (sus scrofa) (Gill et al., 1960).


Gastric Secretion Secretory Response Pepsin Secretion Histamine Stimulation Heidenhain Pouch 
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  • A. C. Ivy
  • W. H. Bachrach

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