Post-Heparin Lipolytic Enzymes in Patients on CAPD

Summary

Serum TC, TG and HDL-C concentrations as well as post-heparin hepatic lipase and lipoprotein lipase activities were studied in CAPD patients and compared to those obtained in normal subjects and HD patients. Female CAPD patients had higher serum TC concentrations than did normal subjects or HD patients. Their mean HDL-C concentration was no different from that of normal subjects, but higher than the corresponding value in HD patients. Male CAPD patients, like their HD counterparts, had markedly reduced HDL-C concentrations. Both male and female CAPD patients had reduced hepatic lipase and lipoprotein lipase activities, but the mean lipoprotein lipase activity of female CAPD patients was higher than that of female HD patients. An inverse correlation between lipoprotein lipase activity and log-TG concentrations and a positive correlation between lipoprotein lipase activity and HDL-C concentrations were established in normal subjects and HD patients, but could not be demonstrated in CAPD patients. Hepatic lipase activity did not correlate with any of the other parameters of lipid metabolism. Reduced lipoprotein lipase activity, which would cause defective triglyceride metabolism, cannot adequately explain the hyperlipidemia in CAPD patients.