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The influence of α-tocopherol-nicotinate (Renascin®) on cardiac glycoside effects

  • Conference paper
Cardiac Glycosides 1785–1985

Summary

The influence of α-tocopherol-nicotinate and related compounds on cardiac glycoside effects on isolated guinea-pig atria and on the glycoside binding to guinea-pig heart homogenate was investigated.

α-tocopherol-nicotinate and dodecanoic acid had an inhibitory effect on the positive inotropic action of digoxin but not on that of ouabain. This effect was parallel to their inhibitory effect of digoxin and not ouabain binding to heart homogenate. The tested compounds showed a protective effect against cardiac glycoside induced arrhythmias which is not in correlation with their effects on the positive inotropic action of the glycosides or on their binding to heart homogenate. The protective effect may be due to a direct action of the drugs on the cell membrane.

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Author information

Author notes

  1. H. Tawfik

    Present address: Department of Pharmacology, Faculty of Pharmacy, Cairo University, el Kasr el Aini street, Cairo, Egypt

  2. Priv. Doz. Dr. P. Schlieper

    Present address: Woelm Pharma GmbH & Co., P. O. Box 840, D-3440, Eschwege, West Germany

Authors and Affiliations

  1. Institute of Pharmacology, University of Düsseldorf, West Germany

    H. Tawfik & Priv. Doz. Dr. P. Schlieper

Authors
  1. H. Tawfik
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  2. Priv. Doz. Dr. P. Schlieper
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Editor information

Editors and Affiliations

  1. Medizinische Klinik I, Klinikum Großhadern der Universität München, Marchioninistraße 15, 8000, München 70, West Germany

    Erland Erdmann

  2. Institut für Pharmakologie, Universität Düsseldorf, Moorenstraße 5, 4000, Düsseldorf, West Germany

    K. Greef

  3. Biophysik Institut, Aarhus Universitet, Universitetparken, 8000, Aarhus, Denmark

    J. C. Skou

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© 1986 Springer-Verlag Berlin Heidelberg

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Tawfik, H., Schlieper, P. (1986). The influence of α-tocopherol-nicotinate (Renascin®) on cardiac glycoside effects. In: Erdmann, E., Greef, K., Skou, J.C. (eds) Cardiac Glycosides 1785–1985. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-11292-2_16

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  • DOI: https://doi.org/10.1007/978-3-662-11292-2_16

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-662-11294-6

  • Online ISBN: 978-3-662-11292-2

  • eBook Packages: Springer Book Archive

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