Summary
Since sympatho-adrenal activity was greatest on the second day after experimental myocardial infarction in the rat, we investigated the responsiveness of cardiovascular adrenoceptors in pithed rats at this time and also determined the number of beta-adrenoceptors in the myocardium of the rats. In addition, the sympathetic outflow was measured, as a presynaptic parameter for estimating sympathetic nervous activity.
The number of beta-adrenoceptor binding sites and the frequency responses of the heart were unchanged by myocardial infarction on the second day. There was also no difference from control animals with respect to sympathetic outflow. However, the rise in diastolic blood pressure, caused by electrical stimulation of the sympathetic nervous system, was far more pronounced in animals with infarction than in controls. In contrast, rats with myocardial infarction exhibited an attenuated response of diastolic blood pressure to infused noradrenaline.
The observed effects can possibly be explained by changes of alpha-adrenoceptors, or perhaps by an enhanced degradation of catecholamines in the endothelium.
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References
Corr PB, Shayman JA, Kramer JB, Kipnis RJ (1981) Increased alpha-adrenergic receptors in ischemic cat myocardium. J Clin Invest 67: 1232–1236
Dominiak P, Türck D (1986) Alterations of β-adrenoceptors subsequent to myocardial infarction. Basic Res Cardiol 81 (Suppl 1): 243–251
Gerlach E, Nees S, Becker BF (1985) The vascular endothelium: a survey of some newly evolving biochemical and physiological features. Basic Res Cardiol 80: 459–474
Maisel AS, Motulsky HJ, Insel PA (1985) Externalization of β-adrenergic receptors promoted by myocardial ischemia. Science 230: 183–186
Mukherjee A, Bush LR, McCoy KE, Duke RJ, Hagler H, Buja LM, Willerson JT (1982) Relationship between β-adrenergic receptor numbers and physiological responses during experimental canine myocardial ischemia. Circ Res 50: 735–741
Stiles GL, Caron MG, Lefkowitz RJ (1984) β-adrenergic receptors: biochemical mechanisms of physiological regulation. Physiol Rev 64: 661–743
Yamaguchi I, Kopin IJ (1979) Plasma catecholamine and blood pressure responses to sympathetic stimulation in pithed rats. Am J Physiol 237: H305 - H310
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Dedicated to Prof. Dr. E. Gerlach on the occasion of his 60th birthday.
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© 1987 Springer-Verlag Berlin Heidelberg
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Türck, D., Dominiak, P. (1987). Changes in cardiovascular adrenoceptor response in rats subsequent to myocardial infarction. In: Jacob, R., Just, H., Holubarsch, C. (eds) Cardiac Energetics. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-11289-2_31
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DOI: https://doi.org/10.1007/978-3-662-11289-2_31
Publisher Name: Steinkopff, Heidelberg
Print ISBN: 978-3-662-11291-5
Online ISBN: 978-3-662-11289-2
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