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Changes in Periventricular Vasculature of Rabbit Brain Following Induction of Hydrocephalus and after Shunting

  • Marc R. Del Bigio
  • J. Edward Bruni

Abstract

Hydrocephalus was induced in young adult rabbits by injection of silicone oil into the cisterna magna. The rabbits were either killed or shunted for one week and then killed at one and eight weeks after the induction of hydrocephalus. Blood vessel profiles in three size groups were quantified by examining the periventricular neuropil with the light microscope. One week after induction of hydrocephalus there was a statistically significant reduction in the number of capillaries in the immediate periventricular region of the corpus callosum (CC), caudate nucleus (CN), and lateral septal area (LSA) and in the deep CC (0.43 mm from the ventricle surface) but not in the deep CN. These changes persisted at eight weeks but to a lesser degree. There were no such changes observed in larger yenules or arterioles. Cerebrospinal fluid shunting reduced the size of the ventricles to normal. When shunting was performed at one week the number of patent capillaries increased such that there were no significant differences from controls except in the LSA. When shunting was performed at eight weeks a similar increase was seen only in the periventricular CC. The observed increase in the number of astroglial cells and reactive astroglia in the periventricular region could serve to prevent re-opening of capillaries when shunting is delayed. These observations support the concept that collapse of capillaries may account for the decrease in cerebral blood flow that has been measured in hydrocephalic brains. (J Neurosurg 69: 115–120, 1988)

Key words

Hydrocephalus Cerebral circulation Pathology 

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Marc R. Del Bigio
    • 1
  • J. Edward Bruni
    • 1
  1. 1.Department of AnatomyThe University of ManitobaWinnipegCanada

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