The Value of Estimating Pressure-volume Index in Childhood Macrocephaly
Most of the information on cerebrospinal fluid (CSF) dynamics is obtained by CSF infusion. The most important variables of CSF dynamics are resistance to absorption or outflow resistance (Ro) and compliance of the CSF spaces. Since pressure varies exponentially as a function of volume, compliance changes with pressure. If the logarithm of CSF pressure is plotted against CSF volume, a linear relationship is formed. The slope of the resulting straight line is defined as the pressure-volume index (PVI).