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The Effect of V-P Shunt on Local Cerebral Glucose Utilization in HTX Congenital Hydrocephalic Rats

  • Makoto Miyaoka
  • Masanori Ito
  • Mitsuru Wada
  • Kiyoshi Sato
  • Ikuko Negishi
  • Shozo Ishii

Abstract

Local cerebral glucose utilization (LCGU) was measured by the [14C]-deoxyglucose autoradiographic method in rats with congenital hydrocephalus before and after V-P shunts. As the hydrocephalus continuously progressed, body weight and motor activity were rapidly decreased at the age of 4 weeks. When hydrocephalus was treated with V-P shunt at this age, the animals increased their food intakes from the following day and motor activity increased rapidly together with body weight.

Key words

Hydrocephalus Cerebral metabolism V-P shunt Rat [14C]-deoxyglucose 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Makoto Miyaoka
    • 1
  • Masanori Ito
    • 2
  • Mitsuru Wada
    • 2
  • Kiyoshi Sato
    • 2
  • Ikuko Negishi
    • 3
  • Shozo Ishii
    • 2
  1. 1.Department of NeurosurgeryFujisawa Municiple HospitalFujisawaJapan
  2. 2.Department of NeurosurgeryJuntendo University School of MedicineTokyoJapan
  3. 3.Central Laboratory of Medical Science, Division of BiochemistryJuntendo University School of MedicineTokyoJapan

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