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Advances in Growth Hormone and Growth Factor Research pp 247–261Cite as

Growth hormone releasing hormone and somatostatin in the physiology and pathophysiology of growth hormone secretion

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Abstract

The regulation of growth hormone (GH) secretion involves a complex neuro-endocrine control system that includes the participation of neurotransmitters and feedback by hormonal and metabolic substrates. The final common integrative pathway for these signals consists of two neuropeptides, which are hypophysiotropic hormones: GH-releasing hormone (GRH), a 40–44-residue peptide which exerts stimulatory effects on GH secretion, and somatostatin (SRIF), a tetradecapeptide which exhibits an inhibitory influence. Although other hypothalamic neuropeptides and monoamines can be demonstrated to exert effects on GH secretion when injected or added to somatotrophs in vitro, there is as yet no convincing evidence for their direct effects on the pituitary under physiologic conditions. They may, however, exert important indirect effects on the regulation of GH secretion by modifying the secretion of GRH and SRIF. Similarly, GRH and SRIF participate in the regulation of GH secretion by neurotransmitter effects within the central nervous system (CNS) on one another or by autocrine effects on their own secretion via ultrashort loot) feedback mechanisms.

The studies in the authors’ laboratory were supported by USPHS grants DK 30667 and RR00068.

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

    L. A. Frohman, P. Chomczynski, T. R. Downs, H. Katakami & J.-O. Jansson

Authors
  1. L. A. Frohman
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  2. P. Chomczynski
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  3. T. R. Downs
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  4. H. Katakami
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  5. J.-O. Jansson
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Editors and Affiliations

  1. Department of Pharmacology, Chemotherapy and Toxicology, University of Milan School of Medicine, Via Vanvitelli, 32, 20129, Milan, Italy

    Eugenio E. MÜller , Daniela Cocchi  & Vittorio Locatelli ,  & 

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© 1989 Springer-Verlag Berlin Heidelberg

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Frohman, L.A., Chomczynski, P., Downs, T.R., Katakami, H., Jansson, JO. (1989). Growth hormone releasing hormone and somatostatin in the physiology and pathophysiology of growth hormone secretion. In: MÜller, E.E., Cocchi, D., Locatelli, V. (eds) Advances in Growth Hormone and Growth Factor Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-11054-6_17

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  • DOI: https://doi.org/10.1007/978-3-662-11054-6_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-11056-0

  • Online ISBN: 978-3-662-11054-6

  • eBook Packages: Springer Book Archive

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