Skip to main content
SpringerLink
Log in

Herstellung von Blutkomponenten

  • Chapter
Transfusionsmedizin

Zusammenfassung

Mit der Möglichkeit, Blutkomponenten im geschlossenen System herzustellen und dem Patienten gezielt nur die Blutbestandteile zuzuführen, die er benötigt, hat sich die Transfusionstherapie in den letzten 50 Jahren von der Vollbluttransfusion zur »Hämotherapie nach Maß« (Hässig) grundsätzlich gewandelt. Die Herstellung und Anwendung von Blutkomponenten bzw. Apheresepräparaten ist heute Standard.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Anderson KC, Goodnough LT, Sayers M, Pisciotto PT, Kurtz SR, Lane TA, Anderson CS, Silberstein LE (1991) Variation in blood component irradiation practice: implications for prevention of transfusion-associated graft-versus-host disease. Blood 77: 2096–2102

    PubMed  CAS  Google Scholar 

  2. Beaujean F, Segier JM, le Forestier C, Duedari N (1992) Leukocyte depletion of red cell concentrates by filtration: influence of blood product temperature. Vox Sang 62: 242–243

    Article  PubMed  CAS  Google Scholar 

  3. Bekanntmachung der Empfehlung des Europarates und der Weltgesundheitsorganisation zu Blut und Blutzubereitungen. Bundesanzeiger, 7. Januar 1993

    Google Scholar 

  4. Bertolini F, Rebulla P, Riccardi D, Cortellaro M, Ranzi ML, Sirchia G (1989) Evaluation of platelet concentrates prepared from buffy coats and stored in a glycosyl-free crystalloid medium. Transfusion 29: 605–609

    Article  PubMed  CAS  Google Scholar 

  5. Bux J, Müller K, Misterek J, Mueller-Eckhardt C (1990) Untersuchungen zur Qualität von Thrombozytenpräparaten aus Buffy coat oder plättchenreichem Plasma. Beitr Infusionsther 26: 99–102

    PubMed  CAS  Google Scholar 

  6. Carmen R (1993)The selection of plastic materials for blood bags. Transfus Med Rev 7: 1–10

    Article  PubMed  CAS  Google Scholar 

  7. Durchführung präparativer zellulärer Hämapheresen zur Gewinnung von Blutbestandteilkonserven. Empfehlungen der ständigen Hämapheresekommission der Deutschen Gesellschaft für Transfusionsmedizin and Immunhämatologie. Infusionsther Transfusionsmed 21: 222–231 (1994)

    Google Scholar 

  8. Eriksson L, Högman CF (1990) Platelet concentrates in an additive solution prepared from pooled buffy coats. 1. In vitro studies. Vox Sang 59: 140–145

    Article  PubMed  CAS  Google Scholar 

  9. Eriksson L, Shanwell A, Gullikson H, Högman CF, Svensson LA, Kristensen J, Berg B (1993)Platelet concentrates in an additive solution prepared from pooled buffy coats. In vivo studies. Vox Sang 64: 133–138

    Article  PubMed  CAS  Google Scholar 

  10. Fijnheer R, Piertersz RNI, de Korte D, Gouwerok CWN, Dekker WJA, Reesink HW, Roos D (1990) Platelet activation during preparation of platelet concentrates: a comparison of the platelet-rich plasma and the buffy coat methods. Transfusion 30: 634–638

    Google Scholar 

  11. Glaser A, Erpenbeck T, Böck M, Heim M, Hempel W (1993) Effectiveness of white cell reduction by filtration with respect to blood storage time. Transfusion 33: 536–537

    Google Scholar 

  12. Hall TL, Barnes A, Miller JR, Bethencourt DM, Nestor L (1993) Neonatal mortality following transfusion of red cells with high plasma potassium levels. Transfusion 33: 606–609

    Article  PubMed  CAS  Google Scholar 

  13. Högman C, Eriksson L, Hedlund K, Wallvik J (1988) The bottom and top system: a new technique for blood component preparation and storage. Vox Sang 55: 211–217

    Article  PubMed  Google Scholar 

  14. Högman CF, Gong J, Eriksson L, Hambraeus A, Johansson CS (1991) White cells protect donor blood against bacterial contamination. Transfusion 31: 620–626

    Article  PubMed  Google Scholar 

  15. Högman CF (1992) New trends in the preparation and storage of platelets. Transfusion 32: 3–6

    Article  PubMed  Google Scholar 

  16. Holme S, Moroff G, Whitley P, Hallinen D, Heaton A (1989) Properties of platelet concentrates prepared after extended whole blood holding time. Transfusion 26: 689–692

    Article  Google Scholar 

  17. International Forum (1992) Should all platelet concentrates issued be leukocyte-poor? Vox Sang 62: 57–64

    Google Scholar 

  18. International Forum (1993) What is the optimal storage temperature for whole blood prior to preparation of blood components. Vox Sang 65: 320–327

    Google Scholar 

  19. Kothe FC, Platenkamp GJ (1994) The use of the sterile connection device in transfusion medicine. Transfus Med Rev 8: 117–122

    Article  PubMed  CAS  Google Scholar 

  20. Kretschmer V, Biermann E, Loh H (1990) Separation of platelet concentrates from buffy coat using the bottom and top drainage system. Beitr Infusionsther 26: 65–70

    PubMed  CAS  Google Scholar 

  21. Leitman SF (1993)Dose, dosimetry, and quality improvement of irradiated blood components. Transfusion 33: 447–448

    Article  PubMed  CAS  Google Scholar 

  22. Luban NLC, Strauss RG, Hume HA (1991) Commentary on the safety of red cells preserved in extended-storage media for neonatal transfusions. Transfusion 31: 229–235

    Google Scholar 

  23. Moroff G, Friedman A, Robkin-Kline L, Gautier G, Luban NLC (1984) Reduction of the volume of stored platelet concentrates for use in neonatal patients. Transfusion 24: 144–146

    Article  PubMed  CAS  Google Scholar 

  24. Moroff G, Holme S (1991) Concepts about current conditions for the preparation and storage of platelets. Transfus Med Rev 5: 48–59

    Google Scholar 

  25. Neppert J, Rejzek T (1993) Entfernung von Additivlösungen. Infusionstherapie 20: 160

    Google Scholar 

  26. Pelszynski MM, Moroff G, Luban NLC, Taylor BJ, Quinones RR (1994) Effect of gamma-irradiation of red blood cell units on T-cell inactivation as assessed by limiting dilution analysis: Implications for preventing transfusion-associated graft versus-host disease. Blood 83: 1683–1689

    PubMed  CAS  Google Scholar 

  27. Piertersz RNI, Loos JA, Reesink HW (1985) Platelet concentrates stored in plasma for 72 hours at 22 °C prepared from buffycoats in citrate-phosphate-dextrose blood collected in a quadruple-bag saline-adenine-glucose-mannitol system. Vox Sang 49: 81–85

    Google Scholar 

  28. Piertersz RNI, Reesink HW, Dekker WJA, Fijen FJ (1987) Preparation of leukocyte-poor platelet concentrates from buffy coats. I. Special inserts for centrifuge cups. Vox Sang 53: 203–207

    Article  Google Scholar 

  29. Piertersz RNI, de Korte D, Reesink HW, Dekker WJA, van den Ende A, Loos JA (1989) Storage of whole blood for up to 24 h at ambient temperature prior to component preparation. Vox Sang 56: 145–150

    Article  Google Scholar 

  30. Piertersz RNI, Reesink HW, Pauw W, Dekker WJA, Buisman L (1992) Prevention of Yersinia enterocolitica growth in redblood-cell concentrates. Lancet 340: 755–756

    Google Scholar 

  31. Piertersz RNI, Steneker I, Reesink HW (1993) Prestorage leukocyte depletion of blood products in a closed system. Transfus Med Rev 7: 17–24

    Article  Google Scholar 

  32. Piertersz RNI (1994)Quality assurance and quality control in component preparation. Vox Sang 67 S3: 197–199

    Google Scholar 

  33. Prins HK, de Bruijn JCGH, Henrichs HPJ, Loos JA (1980) Prevention of microaggregate formation by removal of buffy-coats. Vox Sang 39: 48–51

    Google Scholar 

  34. Ramirez AM, Woodfield DG, Scott R, McLachlan J (1987) High potassium levels in stored irradiated blood. Transfusion 27: 444–445

    Article  PubMed  CAS  Google Scholar 

  35. Read EJ, Kodis C, Carter CS, Leitman SF (1988) Viability of platelets following storage in the irradiated stage. Transfusion 28: 446–450

    Article  PubMed  CAS  Google Scholar 

  36. Richtlinie für die Überwachung des Verkehrs mit Blutzubereitungen. Bundesgesundheitsblatt 3: 105–108 (1989)

    Google Scholar 

  37. Richtlinien zur Blutgruppenbestimmung und Bluttransfusion. Überarbeitete Fassung 1991. Deutscher Ärzteverlag, Köln (1992)

    Google Scholar 

  38. Rock G, Adams A, Labow RS (1988) The effects of irradiation on platelet function. Transfusion 28: 451–455

    Google Scholar 

  39. Rosen NR, Weidner JG, Boldt HD, Rosen DS (1993) Prevention of transfusion-associated graft-versus-host disease: selection of an adequate dose of gamma radiation. Transfusion 33: 125–127

    CAS  Google Scholar 

  40. Simon TL, Sierra ER (1984) Concentration of platelet units into small volumes. Transfusion 24: 173–175

    Article  PubMed  CAS  Google Scholar 

  41. Simon TL (1994)The collection of platelets by apheresis procedures. Transfus Med Rev 8: 132–145

    Article  PubMed  CAS  Google Scholar 

  42. Solberg C, Moen P, Little C (1988) Effect of centrifugation on the storage properties of platelets. Vox Sang 55: 97–103

    Article  PubMed  CAS  Google Scholar 

  43. Solberg C, Hansen JB, Little C (1989) Centrifugation of very freshly donated blood may yield platelets unstable to storage in the new generation of containers. Vox Sang 56: 25–31

    Article  PubMed  CAS  Google Scholar 

  44. Strauss RG (1991) Transfusion Therapy in neonates. Am J Dis Child 145: 904–911

    PubMed  CAS  Google Scholar 

  45. Van Marwijk Kooy M, van Prooijen HC, Moes M, BosmanStants I, Akkerman JWN (1991) Use of leukocyte-depleted platelet concentrates for the prevention of refractoriness and primary HLA alloimmunization: A prospective, randomized trial. Blood 77: 201–205

    Google Scholar 

  46. Walker RH (1993)Technical manual, 11th edn. American Association of Blood Banks (AABB), Bethesda

    Google Scholar 

  47. Walter CW, Murphy WP (1952) A closed gravity technique for the preservation of whole blood in ACD solution utilizing plastic equipment. Surg Gyn Obst 94: 687–692

    PubMed  CAS  Google Scholar 

  48. Washitani Y, Irita Y, Yamamoto K, Shiraki H, Kiyokawa H, Maeda Y, Yoshinari M (1988) Prevention of acquired defects in platelet function during blood processing. Transfusion 28: 571–575

    Article  PubMed  CAS  Google Scholar 

  49. Wunder EW, Henon PR (1993)Peripheral blood stem cell autografts. Springer, Berlin Heidelberg New York

    Google Scholar 

Download references

Authors
  1. J. Bux
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Klinische Immunologie und Transfusionsmedizin der Universität, Langhansstr. 7, D-35385, Gießen, Deutschland

    Christian Mueller-Eckhardt

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Bux, J. (1996). Herstellung von Blutkomponenten. In: Mueller-Eckhardt, C. (eds) Transfusionsmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10599-3_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-10599-3_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-10600-6

  • Online ISBN: 978-3-662-10599-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation