Skip to main content

Physiologie und Pathophysiologie des Immunsystems

  • Chapter
Transfusionsmedizin
  • 249 Accesses

Zusammenfassung

Als Antwort auf die andauernde Bedrohung des Organismus durch die verschiedenartigsten Erreger mit vielfältigen Infektionsstrategien haben Wirbeltiere ein kompliziertes Verteidigungssystem entwickelt das Immunsystem. Es kombiniert spezifische Erkennungsvorgänge, die zur erworbenen Immunität führen, mit unspezifischen Verteidigungsmaßnahmen, der sog. natürlichen Resistenz. Zu letzterer gehören verschiedenartige Schutzmechanismen wie u. a. pH-Wert, eisenbindende Proteine, die direkte Phagozytose oder die alternative Aktivierung des Komplementsystems.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Carding SR, Egan PJ (2002) Gammadelta Tcells: functional plasticity and heterogeneity. Nature Rev Immunol 2: 336–345

    Article  CAS  Google Scholar 

  2. Diefenbach A, Raulet DH (2001) Strategies for target cell recognition by natural killer cells. Immunol Rev 181: 170–184

    Article  PubMed  CAS  Google Scholar 

  3. Fleischer B, Hoerauf A (1999) Spezifische Mechanismen der immunologischen Infektabwehr. Handbuch der Molekularen Medizin, Band IV (Ruckpaul K, Ganten D, Hrsg. ), Springer, Berlin, 341–366

    Google Scholar 

  4. Fleischer B (2000) Superantigenic toxins. Handbook of Experimental Pharmacology 145, Springer, New York, 595–617

    Google Scholar 

  5. Fuleihan RL (2001) Hyper-lgM syndrome: the other side of the coin. Curr Opin Pediatr 13: 528–532

    Article  PubMed  CAS  Google Scholar 

  6. Goldrath AW, Bevan MJ (1999) Selecting and maintaining a diverse T cell repertoire. Nature 402: 255–262

    Article  PubMed  CAS  Google Scholar 

  7. Gumperz JE, Brenner MB (2001) CD1-specific T cells in microbial immunity. Curr Opin Immunol 13: 471–478

    Article  PubMed  CAS  Google Scholar 

  8. Jankovic D, Liu Z, Gause WC (2001) Th1- and Th2-cell commitment during infectious disease: asymmetry in divergent pathways. Trends Immunol 22: 450–457

    Article  PubMed  CAS  Google Scholar 

  9. Jonuleit H, Schmitt E, Steinbrink K, Enk AH (2001) Dendritic cells as a tool to induce anergic and regulatory T cells. Trends Immunol 22: 394–400

    Article  PubMed  CAS  Google Scholar 

  10. Liang L, Sha WC (2002) The right place at the right time: novel B7 family members regulate effector T cell responses. Curr Opin Immunol 14: 384–390

    Article  PubMed  CAS  Google Scholar 

  11. Liu YJ, Kanzler H, Soumelis V, Gilliet M (2001) Dendritic cell lineage, plasticity and cross-regulation. Nat Immunol 2: 585–589

    Article  PubMed  CAS  Google Scholar 

  12. Neurath MF, Finotto S, Glimcher LH (2002) The role of Th1/Th2 polarization in mucosal immunity. Nat Med 8: 567–573

    Article  PubMed  CAS  Google Scholar 

  13. Rammensee HG (1995) Chemistry of peptides associated with MHC class I and class II molecules. Curr Opin Immunol 7: 85–96

    Article  PubMed  CAS  Google Scholar 

  14. Rüssel JH, Ley TJ (2002) Lymphocyte mediated cytotoxicity. Ann Rev Immunol 20: 323–370

    Article  Google Scholar 

  15. Shinkai K, Locksley RM (2000) CD1, tuberculosis, and the evolution of major histocompatibility complex molecules. J Exp Med 191: 907–914

    Article  PubMed  CAS  Google Scholar 

  16. Singer AL, Koretzky GA (2002) Control of T cell function by positive and negative regulators. Science 296: 1639–1640

    Article  PubMed  CAS  Google Scholar 

  17. van Eijk M, Defrance T, Hennino A, de Groot C (2001) Death-receptor contribution to the germinal-center reaction. Trends Immunol 22: 677–682

    Article  PubMed  Google Scholar 

  18. Zinkernagel RM (2002) On differences between immunity and immunological memory. Curr Opin Immunol 14: 523–536

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Fleischer, B. (2004). Physiologie und Pathophysiologie des Immunsystems. In: Mueller-Eckhardt, C., Kiefel, V. (eds) Transfusionsmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10597-9_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-10597-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-10598-6

  • Online ISBN: 978-3-662-10597-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics