Zusammenfassung
Diagnosestellung mittels Ultraschall- oder CT-gesteuerter Feinnadelbiopsie, ggf. ERCP, selektive Angiographie. Tumormarker Ca 19–9 in ca. 80% erhöht.
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Literatur
Brennan MF, Kinsella T, Friedman M (1989) Cancer of the Pancreas. In: DeVita V, Heilman S, Rosenberg SA (eds) Cancer. Principles and Practice of Oncology. Lippincott Company, Philadelphia, 800–834
UICC (1990) TNM Atlas. Illustrated Guide to the TNM/pTNM Classification of Malignant Tumours. Spiess) B et al (eds). Springer, Berlin Heidelberg New York, 126–133
Gudjonsson B (1987) Cancer of the Pancreas. 50 Years of Surgery. Cancer 60: 2284–2303
Moertel CG, Frytak S, Hahn RG et al. (1981) Therapy of locally unresectable pancreatic carcinoma: A randomised comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5 fluorouracil) and high dose radiation + 5 fluorouracil. Cancer 48: 1705–1716
Schein PS, Smith FP, Dritschillo A et al. (1983) Phase I—II trial of combined modality FAM (5fluorouracil, Adriamycin and mitomycin-C) plus split course radiation (FAM-RT-FAM) for locally edvanced gastric (LAG) and pancreatic (LAP) cancer: A Mid-Atlantic Oncology Program study. Proc Am Soc Clin Oncol 2: 216 (abstr)
Whittington R, Solin L, Mohiuddin M et al. (1984) Multimodality therapy of localized unresectable pancreatic adenocarcinoma. Cancer 54: 1991–1998
The Gastrointestinal Tumor Study Group (1985) Radiation therapy combined with adriamycin or 5-fluorouracil for the treatment of locally unresectable pancreatic carcinoma. Cancer 56: 2563–2568
Klaassen DJ, Maclntyre JM, Catton GE et al. (1985) Treatment of locally unresectable cancer of the stomach and pancreas: a randomized comparison of 5-fluorouracil alone with radiation plus concurrent and maintenance 5-fluorouracil. — An Eastern Cooperative Oncology Group Study. J Clin Oncol 3: 373–378
Cohen L, Woodruff KH, Hendrickson FR et al. (1985) Response of pancreatic cancer to local irradiation with highenergy neutrons. Cancer 56: 1235–1241
Gastrointestinal Tumor Study Group (1988) Treatment of locally unresectable carcinoma of the pancreas: comparison of combined-modality therapy (chemotherapy plus radiation) to chemotherapy alone. J Natl Cancer Inst 80: 751–755
Wagener DJT, van Hoessel QCGM, Yap SH, Hoogenraad WJ et al. (1989) Phase II trial of 5fluorouracil, adriamycin and cisplatin (FAP) followed by irradiation and 5-fluorouracil in locally advanced pancreatic cancer. Cancer Chemoth Pharmacol 25: 131–134
Kamthan A, Morris JC, Chesser MR et al. (1992) Combined modality therapy for effective local control in stage II and Ill pancreatic carcinoma. Proc Am Soc Clin Oncol 11: 160 (abstr)
Wagener D, Rougier P, Wils J et al. (1992) Combined chemoradiotherapy for locally advanced pancreatic cancer (LAPC). Proc Am Soc Clin Oncol 11: 166 (abstr)
Komaki R, Wadler S, Peters MS et al. (1992) High-dose local irradiation plus prophylactic hepatic irradiation for inoperable adenocarcinoma of the pancreas. Cancer 69: 2807–2812
Kaiser MH, Ellenberg SS (1985) Pancreatic Cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 120: 899–903
Carter SK, Comis RL (1975) Adenocarcinoma of the pancreas: Current therapeutic approaches, prognostic variables, and criteria of response. In: Cancer Therapy Prognostic Factors and Criteria of Response. Staquet MJ (eds). Raven Press, New York, 237–253
Smith FP, Schein PS (1979) Chemotherapy of pancreatic cancer. Semin Oncol 6: 368–377
Loehrer PJ, Williams SD, Einhorn LH et al. (1985) Ifosfamide: An active drug in the treatment of adenocarcinoma of the pancreas. J Clin Oncol 3: 367–372
Bernard S, Noble S, Wilkosky T et al. (1986) A phase II study of ifosfamide (IFOS) plus n-acetyl cysteine (NAC) in metastatic measurable pancreatic adenocarcinoma (PC). Proc. Am Soc. Clin Oncol 5: 84 (abstr)
Ajani JA, Abbruzzese JL, Goudeau P et al. (1988) Ifosfamide and mesna: marginally active in patients with advanced carcinoma of the pancreas. J Clin Oncol 6: 1703–1707
The Gastrointestinal Tumor Study Group (1989) Ifosfamide is an inactive substance in the treatment of pancreatic carcinoma. Cancer 64: 2010–2013
Wils J, Kok T, Wagener DJT et al. (1993) Phase II trial with ifosfamide in pancreatic cancer. Eur J Cancer 29 A: 290
Wils J, Bleiberg H, Blíjham G et al. (1985) Phase lI study of epirubicin in advanced adenocarcinoma of the pancreas. Eur J Cancer Clin Oncol 21: 191–194
Hochster H, Green MD, Speyer JL et al. (1986) Activity of epirubicin in pancreatic carcinoma. Cancer Treat Rep 70: 299–300
Gastrointestinal Tumor Study Group (1987) Phase II trials of single agents Baker’s antifol, diâziquone, and epirubicin in advanced pancreatic cancer. Cancer Treat Rep 71: 865–867
Loven D, Figer A, Vigler N et al. (1989) Epirubicin in the treatment of advanced carcinoma of the pancreas. Proc Am Soc Clin Oncol 8: 113 (abstr)
Wils J, Kok T, Wagener DJT et al. (1993) Activity of cisplatin in adenocarcinoma of the pancreas. Eur J Cancer 29A: 203–204
Wils JA (1991) Chemotherapy in pancreatic cancer: a rational pursuit? Anti-Cancer Drugs 2: 3–10
Frey C, Twomey P, Keahn R et al. (1981) Randomized study of 5-FU and CCNU in pancreatic cancer. Cancer 47: 27–31
Bukowski RM, Balcerzak SP, O’Bryan RM et al. (1983) Randomized trial of 5-fluorouracil and mitomycin C with or without streptozotocin for advanced pancreatic cancer. Cancer 52: 1577–1582
Cullinan SA, Moertel CG, Fleming TR et al (1985) A comparison of three chemotherapeutic regimens in the treatment of advanced pancreatic and gastric carcinoma. JAMA 253: 2061–2067
Oster MW, Gray R, Panasci L, Perry MC et al. (1986) Chemotherapy for advanced pancreatic cancer: a comparison of 5-fluorouracil, adriamycin and mitomycin (FAM) with 5-fluorouracil, streptozotocin and mitomycin ( FSM ). Cancer 57: 29–33
The Gastrointestinal Tumor Study Group (1986) Phase lI studies of drug combinations in advanced pancreatic carcinoma: fluorouracil plus doxorubicin plus mitomycin c and two regimens of streptozotocin plus mitomycin c plus fluorouracil. J Clin Oncol 4: 1794–1798
Hudis C, Kelsen D, Dougherty J et al. (1990) A randomized trial of streptozotocin (S), mitomycin (M), and 5-fluorouracil (F) (SMF) vs. cisplatin (P), ara-c (A) and coffeine (C) (CAC) in advanced pancreatic cancer (PC). Proc Am Soc Clin Oncol 9: 107 (abstr)
Cullinan S, Moertel C, Wieand H et al. (1990) A phase Ill trial on the therapy of advanced pancreatic carcinoma. Evaluations of the Mallinson regimen and combined 5-fluorouracil, doxorubicin, and cisplatin. Cancer 65: 2207–2212
Hansen R, Quebbeman E, Ritch P et al. (1988) Continuous 5-fluorouracil (5-FU) infusion in carcinoma of the pancreas: a phase II study. Am J Med Sci 295: 91–93
Vaughn C, Chapman J, Chinn B et al. (1989) Activity of 5-fluorouracil, mitomycin C, and methyl CCNU in inoperable adenocarcinoma of the pancreas. Am J Clin Oncol 12: 49–52
DeCaprio JA, Arbuck SG, Mayer RJ (1989) Phase lI study of weekly 5-fluorouracil (5-FU) and folinic acid (FA) in previously untreated patients with unresectable, measurable pancreatic adenocarcinoma. Proc Am Soc Clin Oncol 5: 100 (abstr)
Schilder RJ, Paul AR, Walczak J et al. (1990) Phase II trial of PALA/5-fluorouracil in pancreatic cancer. Proc Am Soc Clin Oncol 9: 109 (abstr)
Basile M, Rougier P, Ducreux M et al. (1991) A phase II study of 5-FU continuous infusion (CI) and CDDP (P) in measurable advanced carcinoma of the pancreas (PC). Proc Am Soc Clin Oncol 10: 149 (abstr)
Crown J, Casper ES, Botet J et al. (1991) Lack of efficacy of high-dose leucovorin and fluorouracil in patients with advanced pancreatic adenocarcinoma. J Clin Oncol 9: 1682–1686
Rothman H, Cantrell JE, Lokich J et al. (1991) Continuous infusion 5-fluorouracil plus weekly cisplatin for pancreatic carcinoma. Cancer 68: 264–268
Tian E, Ardalan B, Benedetto P et al. (1992) A phase II study of short term protracted infusion high dose 5-fluorouracil (5-FU) with leucovorin (LV) and low dose phosphonacetyl-I-aspartic acid (PALA) in pancreatic carcinoma. Proc Am Soc Clin Oncol 11: 184 (abstr)
Gastrointestinal Tumor Study Group (1987) Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Cancer 59: 2006–2010
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© 1993 Springer-Verlag Berlin Heidelberg
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Wils, J. (1993). Pankreaskarzinom. In: Seeber, S., Schütte, J. (eds) Therapiekonzepte Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10495-8_16
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DOI: https://doi.org/10.1007/978-3-662-10495-8_16
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