Skip to main content

Zusammenfassung

Ca. 0,2–1,5% aller malignen Tumoren; ca. 20% aller mediastinalen Tumoren und ca. 50% der Tumoren im vorderen oberen Mediastinum. Altersgipfel um das 50. Lebensjahr ohne eindeutige Geschlechtsprädilektion.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Verley J, Hollmann K (1985) Thymoma — A comparative study of clinical stages, histologic features, and survival in 200 cases. Cancer 55: 1974–1086

    Article  Google Scholar 

  2. Batata M, Martini N, Huvos A, Aguilar R, Beattie E (1974) Thymomas, Clinicopathologic features, therapy, and prognosis. Cancer 34: 389–396

    Google Scholar 

  3. LeGolvan D, Abell M (1977) Thymomas. Cancer 39:2142— 2157

    Google Scholar 

  4. Rosai J, Levine GD (1976) Tumors of the thymus. Atlas of tumor pathology 2nd series. Washington DC: Armed Forces Institute of Pathology, S 34–153

    Google Scholar 

  5. Nakahara K, Ohno K, Hashimoto J, Maeda H, Miyoshi S, Sakurai M, Monden Y, Kawashima Y (1988) Thymoma: Results with complete resection and adjuvant irradiation in 141 consecutive patients. J Thorac Cardiovasc Surg 95: 1041–1047

    PubMed  CAS  Google Scholar 

  6. Maggi G, Giaccone G, Donadio M, Ciuffreda L, Dalesio O, Leria G, Trifiletti G, Casadio C, Palestro G, Manusco M, Calciati A (1986) Thymoma — A review of 169 cases, with particular reference to results of surgical treatment. Cancer 58: 765–776

    Article  PubMed  CAS  Google Scholar 

  7. Maggi G, Casadio C, Cavallo A, Cianci R, Molinatti M, Ruffini E (1991) Thymoma: Results of 241 operated cases. Ann Thorac Surg 51: 152–156

    Article  PubMed  CAS  Google Scholar 

  8. Bergh NP, Gatzinsky P, Larsson S (1981) Tumors of the thymus and thymic region: I. Clinocopathological studies of thymomas. Ann Thorac Surg 25: 91–99

    Google Scholar 

  9. Sellors TH, Thackray AC, Thomson AD (1967) Tumors of the thymus. Thorax 22: 193–221

    Article  PubMed  CAS  Google Scholar 

  10. Wang L, Huang M, Lin T, Huang B, Vjien K (1992) Malignant thymoma. Cancer 70: 443–450

    Article  PubMed  CAS  Google Scholar 

  11. Marino M, Müller-Hermelink H (1985) Thymoma and thymic carcinoma. Relation of thymoma epithelial cells to the cortical and medullary differentiation of thymus. Virchows Arch [Pathol Anat] 407: 119–149

    Google Scholar 

  12. Kirchner T, Schalke B, Buchwald J, Ritter M, Marx A, Müller-Hermelink H (1992) Well-differentiated thymic carcinoma. An organotypical low-grade carcinoma with relationship to cortical thymoma. Am J Surg Pathol 16: 1153–1169

    Google Scholar 

  13. Quintanilla-Martinez L, Wilkins E, Choi N, Efird J, Hug E, Harris N (1994) Thymoma. Histologic subclassification is an independent prognostic factor. Cancer 74: 606–617

    Google Scholar 

  14. Pescarmona E, Rendina E, Venuta F, Ricci C, Ruco L, Baroni C (1990) The prognostic implication of thymoma histologic subtyping. A study of 80 consecutive cases. Am J Clin Pathol 93: 190–195

    PubMed  CAS  Google Scholar 

  15. Kuo T, Lo S (1993) Thymoma: A study of the pathologic classification of 71 cases with evaluation of the Müller-Hermelink system. Hum Pathol 24: 766–771

    Article  PubMed  CAS  Google Scholar 

  16. Arrigada R, Bretel J, Caillaud J, Garreta L, Guerin R, Laugier A, Le Chevallier T, Schlienger M (1984) Invasive Carcinoma of the Thymus. A multicenter retrospective review of 56 cases. Eur J Cancer Clin Oncol 20: 69–74

    Article  Google Scholar 

  17. Masaoka A, Monden Y, Nakahara K, Tanioka T (1981) Follow-up study of thymomas with special reference to their clinical stages. Cancer 48: 2485–2492

    Article  PubMed  CAS  Google Scholar 

  18. Urgesi A, Monetti U, Rossi G, Ricardi G, Ricardi U, Casadio C (1990) Role of radiation therapy in locally advanced thymoma. Radiother Oncol 19: 273–280

    Article  PubMed  CAS  Google Scholar 

  19. Souadjian W, Enrequez P, Siverstein MN (1974) The spectrum of diseases associated with thymoma. Arch Intern Med 134: 374–381

    Article  PubMed  CAS  Google Scholar 

  20. Pollack A, Komaki R, Cox J, Ro J, Oswald M, Shin D, Putnam J (1992) Thymoma: Treatment and prognosis. Int J Radiation Oncology Biol Phys 23: 1037–1043

    Google Scholar 

  21. Monden Y, Nakahara K, Iioka S, Nanjo S, Ohno K, Fujii Y, Hashimoto J, Kitagawa Y, Masaoka A, Kawashima Y (1985) Recurrence of thymoma: Clinicopathological features, therapy, and prognosis. Ann Thorac Surg 39: 165–169

    Google Scholar 

  22. Ariaratnam LS, Kalnicki S, Mincer F (1979) The management of malignant thymoma with radiaton therapy. Int J Radiat Oncol Biol Phys 5: 77–80

    Article  PubMed  CAS  Google Scholar 

  23. Curran W, Kornstein M, Brooks J, Turrisi A (1988) Invasive thymoma: The role of the mediastinal irradiation following complete or incomplete surgical resection. J Clin Oncol6: 1722–1727

    Google Scholar 

  24. Krueger J, Sagerman R, King G (1988) Stage III thymoma: Results of postoperative radiation therapy. Radiology 168: 855–858

    Google Scholar 

  25. Kersh C, Eisert D, Hazra T (1985) Malignant thymoma: Role of radiation therapy in management. Radiology 156: 207–209

    Google Scholar 

  26. Ciernik I, Meier U, Liftoff’ U (1994) Prognostic factors and outcome of incompletely resected invasive thymoma following radiation therapy. J Clin Oncol 12: 1484–1490

    PubMed  CAS  Google Scholar 

  27. Cohen D, Ronnigen L, Graeber G, Deshong J, Jaffin J, Burge J, Zajtchuk R (1984) Management of patients with malignant thymoma. J Thorac Cardiovasc Surg 87: 301–307

    PubMed  CAS  Google Scholar 

  28. Loehrer P (1993) Thymomas. Current experience and future directions in therapy. Drugs 45: 477–487

    Article  PubMed  CAS  Google Scholar 

  29. Hu E, Levine J (1986) Chemotherapy of malignant thymoma — Case report and review of the literature. Cancer 57: 1101–1104

    Article  PubMed  CAS  Google Scholar 

  30. Harper P, Highley M, Rankin E, Dussek J, Bryant B (1991) Ifosfamide mono-therapy demonstrates high activity in malignant thymoma. Proc Amer Soc Clin Oncol 10: 1049

    Google Scholar 

  31. Shellito J, Khandekar J, McKeever W, Vick N (1978) Invasive thymoma responsive to oral corticosteroids. Cancer Treat Rep 62: 1397–1400

    PubMed  CAS  Google Scholar 

  32. Tandan R, Taylor R, DiCostanzo D, Sharma K, Fries T, Roberts J (1990) Metastasizing thymoma and myastenia gravis. Favorable response to glucocorticoids after failed chemotherapy and radiaton therapy. Cancer 65: 1286–1290

    Google Scholar 

  33. Kosmidis P, Iliopoulos E, Pentea S (1988) Combination chemotherapy with cyclophosphamide, adriamycin, and vincristine in malignant thymoma and myastenia gravis. Cancer 61: 1736–1740

    Article  PubMed  CAS  Google Scholar 

  34. Evans W, Thompson D, Simpson W, Feld R, Phillips M (1980) Combination chemotherapy in invasive thymoma — Role of COPP. Cancer 46: 1523–1527

    Article  PubMed  CAS  Google Scholar 

  35. Göldel N, Böning L, Frederik A, Hölzel D, Hartenstein R, Wilmanns W (1989) Chemotherapy of invasive thymoma. A restrospective study of 22 cases. Cancer 63: 1493–1500

    Article  PubMed  Google Scholar 

  36. Uematsu M, Kondo M (1986) A proposal for treatment of invasive thymoma. Cancer 58: 1979–1984

    Article  PubMed  CAS  Google Scholar 

  37. Chahinian A, Bhardwaj S, Meyer R, Jaffrey I, Kirschner P, Holland J (1981) Treatment of invasive or metastatic thymoma — Report of eleven cases. Cancer 47: 1752–1761

    Article  PubMed  CAS  Google Scholar 

  38. Dy C, Calvo F, Mindan J, Aparicio L, Algarra S, Gil A, Gonzalez F, Harguindey S (1988) Undifferentiated epithelial-rich invasive malignant thymoma: Complete response to cisplatin, vinblastine, and bleomycin therapy. J Clin Oncol 6: 536542

    Google Scholar 

  39. Fornasiero A, Daniele O, Ghiotto C, Piazza M, Fiore-Donati L, Calabro F, Rea F, Fiorentino M (1991) Chemotherapy for invasive thymoma — A 13-year experience. Cancer 68: 30–33

    Article  PubMed  CAS  Google Scholar 

  40. Loehrer P, Kim K, Aisner S, Livingston R, Einhorn L, Johnson D, Blum R (1994) Cisplatin plus doxorubicin plus cyclophosphamide in metastatic or recurrent thymoma: Final results of an Intergroup trial. J Clin Oncol 12: 1164–1168

    Google Scholar 

  41. Berruti A, Borasio P, Roncari A, Gorzegno G, Mossetti C, Dogliotti L (1993) Neoadjuvant chemotherapy with adriamycin, cisplatin, vincristin and cyclophosphamide (ADOC) in invasive thymomas: results in six patients. Ann Oncol 4: 429–431

    PubMed  CAS  Google Scholar 

  42. Macchiarini P, Chella A, Ducci F, Rossi B, Testi C, Bevilacqua G, Angeletti C (1991) Neoadjuvant chemotherapy, surgery, and postoperative radiation therapy for invasive thymoma. Cancer 68: 706–713

    Article  PubMed  CAS  Google Scholar 

  43. Berthaud P, LeChevalier T, Tursz T (1990) Effectiveness of interleukin-2 in invasive lymphoepithelial thymoma. Lancet 335: 1590

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Schütte, J. (1995). Thymome. In: Seeber, S., Schütte, J. (eds) Therapiekonzepte Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10494-1_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-10494-1_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58586-2

  • Online ISBN: 978-3-662-10494-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics