Zusammenfassung
Die histologische Klassifikation erfolgt nach der überarbeiteten Fassung der Weltgesundheitsorganisation von 1981 [4]. Danach werden 3 Tumortypen nicht-kleinzelliger Karzinome unterschieden:
-
I
Plattenepithelkarzinom (epidermoidales Karzinom), Variante: spindelzelliges Plattenepithelkarzinom.
-
II
Adenokarzinome
-
1
azinäres Adenokarzinom,
-
2
papilläres Adenokarzinom,
-
3
bronchiolo-alveoläres Karzinom,
-
4
solides, schleimbildendes Adenokarzinom.
-
1
-
III
Großzelliges Bronchialkarzinom
-
1
großzelliges Karzinom mit Riesenzellen,
-
2
hellzelliges Bronchialkarzinom.
-
1
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Becker N, Frentzel-Beyme R, Wagner G (1984) Krebsatlas der Bundesrepublik Deutschland, 2. Auflage, Springer, Berlin Heidelberg New York Tokyo
Boring CC, Squires TS, Tong T (1993) Cancer Statistics 1993, CA/Cancer J Clin 43: 7–26
Zeller WJ, Schmähl D (1985) Ätiologie des Bronchialkarzinoms. In: Trandelenburg F (Hrsg): Tumoren der Atmungsorgane und des Mediastinums. Handbuch der Inneren Medizin IV/4A, Springer, Berlin Heidelberg New York Tokyo: 51–86
World Health Organization (1982) The World Health Organization Histological Typing of Lung Tumors, 2nd edn. Am J Clin Pathol 77:123–136
Müller KM, Fisseler-Eckhoff A (1991) Pathologie der Lungentumoren in Drings P, Vogt-Moykopf I (Hrsg) Thoraxtumoren Diagnostik-Staging-gegenwärtiges Therapiekonzept, Springer-Verlag, Berlin Heidelberg New York S. 5–24
Hermanek P, Sobin LH eds (1987) TNM Classification of Malignant Tumours. 4th ed. Geneva: International Union Against Cancer
Drings P, Vogt-Moykopf I (1988) Das nicht-kleinzellige Bronchialkarzinom, Deutsches Ärzteblatt 85: 2146–2151
Bülzebruck H, Bopp R, Drings P, Bauer E, Krysa S, Probst G, van Kaick G, Müller K-M, Vogt-Moykopf I (1992) New Aspects in the Staging of Lung Cancer, Cancer 70: 1102–1110
Vogt-Moykopf I, Krysa S, Probst G, Bülzebruck H, Schirren J, Branscheid D, Anyanwu E, Bauer E, Stoelben E (1991) Pathologie der Lungentumoren in Drings P, Vogt-Moykopf I (Hrsg) Thoraxtumoren Diagnostik-Staging-gegenwärtiges Therapiekonzept, Springer-Verlag, Berlin Heidelberg New York, S 170–186
Vogt-Moykopf I (1993) Persönliche Mitteilung
Kimmig B, Vogel D, Flentje M, Wannenmacher M (1991) Pathologie der Lungentumoren in Drings P, Vogt-Moykopf I (Hrsg) Thoraxtumoren DiagnostikStaging-gegenwärtiges Therapiekonzept, Springer-Verlag, Berlin Heidelberg New York, S 199–211
l la. Slater JD, Ellerbroek NA, Barkley Jr T, Mountain C, Oswald MJ, Roth JA, Peters LJ (1991) Radiation therapy following resection of non-small cell bronchogenic carcinoma. Int J Radiation Oncology Biol Phys, Vol 20: 945–951
lb. Phlips P, Rocmans P, Vanderhoeft P, van Houtte P (1993) Postoperative radiotherapy after pneumonectomy: impact of modern treatment facilities. Int J Radiation Oncology Biol Phys, Vol 27:525–529
Neal CR, Amdur RJ, Mendenhall WM, Knauf DG, Block AJ, Million RR (1991) Pancoast tumor: radiation therapy alone versus preoperative radiation therapy and surgery. Int J Radiation Oncology Biol Phys, Vol 21: 651–660
l ld. Komaki R, Mountain CF, Holbert JM, Garden AS, Shallenberger R, Cox JD, Maor MH, Guinee VF, Samuels B (1990) Superior sulcus tumors: treatment selection and results for 85 patients without metastasis (MO) at presentation. Int J Radiation Oncology Biol Phys, Vol 19: 31–36
Schraube P, Latz D (1993) Wertigkeit der Strahlentherapie bei der Behandlung des Pancoast-Tumors der Lunge. Strahlentherapie und Onkologie 5: 265–269
Kuttig H (1986) Palliative Radiotherapie der nicht-kleinzelligen Bronchialkarzinome. In: Drings P, Schnähl D, Vogt-Moykopf I (Hrsg) Bronchialkarzinom, Aktuelle Onkologie 26. Zuckschwerdt Verlag, München Bern Wien, S 366-379
Joss PA, Brunner KW (1985) Die Chemotherapie der nichtkleinzelligen Bronchialkarzinome. In: Seeber S, Niederle N (Hrs): Interdisziplinäre Therapie des Bronchialkarzinoms. Springer-Verlag, Berlin, S 75–94
Bakowski MT, Crouch JC (1983) Chemotherapy for Non-Small Cell Lung Cancer. A Reappraisal and a Look to the Future. Cancer Treatm Rep 10: 159–172
Sculier JP, Klastersky J (1984) Progress in Chemotherapy of Non-Small Cell Lung Cancer, Europ J Cancer Clin Oncol 20: 1329–1333
Hazuka MB, Bunn PA (1992) Controversies in the Nonsurgical Treatment of Stage III Non-Small Cell Lung Cancer, Am Rev Respir Dis 145: 967–977
Folman RS, Rosman M (1988) The Role of Chemotherapy in Non-Small Cell Lung Cancer: The Community Perspective: Sem Oncol 15: 16–21
Eberhardt W, Niederle N (1992) Ifosfamide in Non-Small Cell Lung Cancer: a Review, Sem Oncol 19: 40–48
Haraf DJ, Devine S, Ihde DC, Vokes EE (1992) The Evolving Role of Systemic Therapy in Carcinoma of the Lung, Sem oncol 19: 72–87
Ihde DC (1992) Chemotherapy of Lung Cancer, New Engl J Med 327: 14341441
Sandler AB, Buzaid AC (1992) Lung Cancer: A Review of Current Therapeutic Modalities, Lung 170: 249–265
Aaronson NK, Bullinger M, Ahmedzai S (1988) A Modular Approach to Qualityof-Life Assessment in Cancer Clinical Trials, Recent Results in Cancer Research 111:231–249, Springer-Verlag, Berl in Heidelberg
Lung Cancer Study Group (1988) The Benefit of Adjuvant Treatment for Resected Locally Advanced Non-Small Cell Lung Cancer. J Clin Oncol 6: 9–17
Rose LJ (1991) Neoadjuvant and Adjuvant Therapy of Non-Small Cell Lung Cancer, Sem Oncol 18: 536–542
Strauss GM, Langer MP, Elias AD, Skarin AT, Sugarbaker DJ (1992) Multi-modality Treatment of Stage III A Non-Small Cell Lung Carcinoma: A Critical Review of the Literature and Strategies for Future Research, J Clin Oncol 10: 829–838
Schaake-Koning C, van den Bogaert W, Dalesio O, Festen J, Hoogenhout J, van Houtte P, Kirkpatrick A, Koolen M, Maat B, Nijs A, Renaud A, Rodrigus P, Schuster-Uitterhoeve L, Sculier J-P, van Zandwijk N, Bartelink H (1992) Effects of Concomitant Cisplatin and Radiotherapy on Inoperable Non-Small Cell Lung Cancer, New Engl J Med 326: 524–530
Rapp E, Pater JL, Willan A, Cormier Y, Murray N, Evans WK, Hodson DI, Clark DA, Feld R, Arnold AM, Ayoub JI, Wilson KS, Latreille J, Wierzbicki RF, Hill DP (1988) Chemotherapy Can Prolong Survival in Patients with Advanced Non-Small Cell Lung Cancer — Report of a Canadian Multicenter Randomized Trial, J Clin Oncol 6: 633–641
Wilke H, Achterrath W, Gunzer U, Fink U, Preusser P, Schmoll H-J (1987) Etoposide and Split Dose of Cisplatin. A Phase II Study in Non-Small Cell Lung Cancer (NSCLC) Tumor Diagnostik und Therapie 8: 194–198
Longeval E, Klastersky J (1982) Combination Chemotherapy with Cisplatin and Etoposide in Bronchogenic Squamous Cell Carcinoma and Adenocarcinoma, Cancer 50: 2751–2756
Gralla RJ, Casper ES, Kelsen DP, Braun DW, Dukeman ME, Martini N, Young CW, Golbey RB (1981) Cisplatin and Vindesine Combination Chemotherapy for Advanced Carcinoma of the Lung: A Randomized Trial Investigating two Dosage Schedules, Ann Intern Med 95: 414–420
Drings P, Abel U, Bülzebruck H, Stiefel P, Kleckow M, Manke H-G (1986) Experience with Ifosfamide Combinations (Etoposide or DDP) in Non-Small Cell Lung Cancer, Cancer Chemother Pharmacol 18 (Suppl 2): 34–39
Shephard FA, Evans WK, Goss PE, Latreille J, Logan D, Maropun J, Stewart D, Warner E, Paul K (1992) Ifosfamide, Cisplatin and Etoposide ( ICE) in the Treatment of Advanced Non-Small Cell Lung Cancer, Sem Oncol 19: 54–58
Shirinian M, Lee JS, Dhingra HH, Greenberg J, Hong WK (1992) Phase II Study of Cisplatin, Ifosfamide with mesna and Etoposide ( PIE) Chemotherapy for Advanced Non-Small Cell Lung Cancer, Sem Oncol 19: 49–53
Cullen MH, Joshi R, Chetiyawardana AD, Woodroffe CM (1988) Mitomycin, Ifosfamide and Cisplatin in Non-Small Cell Lung Cancer: Treatment Good Enough to Compare, Br J Cancer 58: 359–361
von Rohr A, Anderson H, McIntosh R, Thatcher N (1991) Phase II Study with Mitomycin, Ifosfamide and Carboplatin in Inoperable Non-Small Cell Lung Cancer, Eur J Cancer 27: 1106–1108
Wolf M, Havemann K, Stalleicken D, Gropp C, Maasberg M, Hans K, von Bültzingslöwen F, Klasen H, Becker H, Schroeder M, Hruska E, Hirschmann H, Gerdes H, Häßler R, Mende S, Pieritz HG, Braun C, Holle R (1988) Ergebnisse zweier multizentrischer Therapiestudien beim inoperablen nichtkleinzelligen Bronchialkarzinom, Onkologie 11: 222–231
Kris MG, Gralla RJ, Wertheim MS, Kelsen DP, O’Conell JP, Burke MT, Fiore JJ, Cibas IR, Heelan RT (1986) Trial of the Combination of Mitomycin, Vindesine and Cisplatin in Patients with Advanced Non-Small Cell Lung Cancer, Cancer Treat Rep 70: 1091–1096
Miller TP, Vance RB, Ahmann FR, Rodney SR (1986) Extensive Non-Small Cell Lung Cancer Treated with Mitomycin, Cisplatin and Vindesine (MiPE): A Southwest Oncology Group Study, Cancer Treat Rep 70: 1101–1104
Sculier JP, Klastersky J, Dumont JP, Vandermoten G, Rocmans P, Libert P, Rayez P, Becquart D, Mommen P, Dalesio 0 (1986) Combination Chemotherapy with Mitomycin and Vindesine in Advanced Non-Small Cell Lung Cancer: A Pilot Study by the Lung Cancer Working Party (Belium) Cancer Treat Rep 70: 773–775
Gatzemeier U, Hossfeld DK, Magnussen H, Radenbach D, Zschaber R (1987) Combination Chemotherapy with Mitomycin C, Ifosfamide and Vindesine in the Treatment of Non-Small Cell Lung Cancer, Contr Oncol 26: 375–383
Durrant KR, Berry RJ, Ellis F, Ridehalgh FR, Black JM, Hamilton WS (1971) Comparison of treatment policies in inoperable bronchial carcinoma. Lancet 1: 715–719
Laing AH, Berry RJ, Newman CR, Peto J (1975) Treatment of inoperable carcinoma of the bronchus. Lancet 2: 1161–1164
Cormier YD, Bergeron J, la Forge, Lavandrier M, Foernier M, Chenard J, Des-meules M (1982) Benefits of polychemotherapy in advanced non small cell bronchogenic carcinoma. Cancer 50: 845–849
Ganz PA, Figlin RA, Hasekell CM, la Soto N, Siau J (1989) Supportive care versus supportive care and combination chemotherapy in metastatic non-small cell lung cancer. Cancer 63: 1271–1278
Woods RL, Williams CJ, Levi J, Page J, Bell D, Byrne M, Kerestes ZL (1990) A randomized trial of cisplatin and vindesine versus supportive care only in advanced non-small cell lung cancer. Br J Cancer 61: 608–611
Cellerino R, Tummarello D, Guido F, Isidori P, Raspugli M, Biscottini B (1991) A randomized trial off alterning chemotherapy versus best supportive care in advanced non-small cell lung cancer. J Clin Oncol 9: 1454–1461
Kaasa S, Lund E, Thorud E, Hatlevoll R, Host H (1991) Symptomatic treatment versus combination chemotherapy for patiets with extensive non-small cell lung cancer. Cancer 67: 2443–2447
Tubiana M, Arriagada R, Cosset JM (1985) Sequencing of drugs and radiation. Cancer 55: 2131–2139
Looney WB, Goldie JH, Little JB, Hopkins HA, Read EJ, Wittes R (1985) Alternation of chemotherapy and radiotherapy in cancer management. 1. Summary of the division of cancer treatment workshop. Cancer Treatment Rep 69: 769–775
Mattson K, Holsti LR, Holsti P, Jabsson M, Kajanti M, Liipo K, Mäntylä M, Korhonen SN, Nikkanen V, Nordman E, Platin LH, Pyrhönen S, Romppanien ML, Salmi R, Tammilehto L, Taskinen PJ (1988) Inoperable non-small cell lung cancer: Radiation with or without chemotherapy. Eur J Cancer Clin Oncol 24: 477–482
Dillmann RO, Seagren SL, Propert KJ, Guerra J, Eaton WL, Perry MC, Carey RW, Frei III EF, Green MR (1990) A randomized trial of induction chemotherapy plus high-dose radiation versus radiation in stage III non-small cell lung cancer. N Engl J Med 323: 940–445
Morton RF, Jett JR, McGinnis WL, Earle JD, Thereau TM, Krook JE, Elliott TE, Maillard JA, Nelimark RA, Maksymuik AW, Drummond RG, Laurie JA, Kugler JW, Anderson RT (1991) Thoracic radiation therapy alone compared with combined chemo-/radiotherapy for locally unresectable non-small cell lung cancer. Ann Intern Med 115: 681–686
Le Chevalier T, Arriagada R, Quoix E, Ruffle P, Martin M, Tarayre M, La combe-Terrier MI, Douillard JY, Laplanche A (1991) Radiotherapy alone versus combined chemotherapy and radiotherapy in nonresectable non-small cell lung cancer: first analysis of a randomized trial in 353 patients. J Natl Cancer Inst 83: 417–423
Chapman R, Lewis J, Kvale P, Lehman D, Mettetal M, Doyle T, Janakiraman N (1990) A neoadjuvant trial in stage II and stage III a non-small cell lung cancer with cisplatinum and vinblastine chemotherapy. Proc Am Soc Clin Onco 19: 246, A954
Gralla RJ (1988) Preoperative and adjuvant chemotherapy in non-small cell lung cancer. Sem Oncol 15 (Suppl 7): 8–12
Vohes EE, Britan JD, Hoffmann PC, Ferguson MK, Weichselbaum RR, Golomb HM (1989) Neoadjuvant vindesine, etoposide and cisplatinum for locally advanced non-small cell lung cancer. Finan report of a phase II study. Chest 96: 110–113
Martini N, Kris MG, Gralla RJ, Bains MS, McCormack PM, Kayser LR, Burt ME, Zaman MB (1988) The effects of preoperative chemotherapy on the resectability of non-small cell lung carcinoma with mediastinal lmyph node metastases ( N2 MO ). Ann Thorac Surg 45: 370–379
Einhorn LH (1988) Neoadjuvant therapy of stage III non-small cell lung cancer. Ann Thorac Surg 46: 362–365
Rosell R, Gomez-Godina J, Camps C, Mastre J, Padille J, Canto A, Mate JL, La S, Roig J, Olazabai A, Canela M, Ariza A, Skagel Z, Morera-Prat J, Arad A (1994) A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small cell lung cancer. New Engl J Med 333: 153–158
Roth JA, Fossela F, Komaki R, Ryan MB, Putnam Jr JB, Jin Soo Lee, Dhingra H, de Caro L, Chasen M, McGavran M, Atkinson EN, Hong WK (1994) A randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage III A non-small cell lung cancer. J Natl Cancer Inst 86: 673–680
Bitran JD, Golomb HM, Hoffmann PC, Albain K, Evans R, Little AG, Purl S, Skosey C (1986) Protochemotherapy in non-small cell lung carcinom. An attempt to increase surgical resectability and survival: A preliminary report. Cancer 57: 44–53
Takita H, Regal AM, Antkowiak JG, Rao UNM, Botsoglou NK, Lane WW (1986) Chemotherapy followed by lung resection in inoperable non-small cell lung carcinoma due to locally far-advanced disease. Cancer 57: 630–635
Israel I, Breau JL, Morere JM (1986) Chimiotherapie preoperatoire dans 57 cas de cancers bronchiques epidermoides. Amalyse des responses, des complications et de la survie. Neoadjuvant Chemotherapy. Coll. INSERM/John Libbey, Eurotext 137: 463–465
Clavier J, Zabbe CL, Raut Y, Briere J, Larzul KK, Kerbourch JF, Nguyen-Huu N (1986) Chimitherapie preoperatiore dans le cancera bronchiques epidermoides. Resultats d’une etude pilote portant sur 60 patients. Neo-adjuvant chemotherapy. Coll. INSERM-/John Libbey, Eurotext 137: 473–478
Bonomi P, Trybulla M, Sander S, Taylor S, Howard-Ruben J, Busby J, Mattey S, Lee MS, Reddy S, Faber LP (1986) Comparison of neoadjuvant chemotherapy (Neo-CT) alone to simultaneous chemotherapy (SCT-RT) in locally advanced squamous cell bronchogenic carcinoma (sq CBS). Neo-adjuvant chemotherapy. Coll. INSERM/John Libbey Eurotext 137: 505–517
Kris MG, Gralla RJ, Martinin M, Stampleman LV, Burke MT (1987) Preoperative and adjuvant chemotherapy in locally advanced non-small cell lung cancer. Surg Clin North Arm 67: 1051–1059
Spain R (1988) Neoadjuvant mitomycin C, cisplatin, and infusion vinblastine in locally and regionally advanced non-small cell lung cancer: problems and progress from the perspective of long-term follow-up. Sem Oncol 15, Suppl 4: 6–15
Burkes RL, Shepherd FA, Ginsberg RJ, Blackstein ME, Goldberg ME, Todd T, Pearson FG, Jones D, Greenwood C (1994) Induction chemotherapy with MVP in patients with stage IIIa (Tl-3, N2, MO) unresectable non-small cell lung cancer ( NSCLC ): The Toronto experience. Proc ASCO 13: 327
Pujol JL, Rossi JF, Le Chevalier T, Daures JP, Rouanet P, Douillard JY, Dubois JB, Arriagada R, Mary H, Godard P, Michel FB (1990) Pilot study of neoadjuvant ifosfamid, cisplatin, and etoposide in locally advanced non-small cell lung cancer. Eur J Cancer 26: 798–801
Henriquez I, Munoz-Galindo L, Rebello J, Vieitez JM, Gonzales-Monzana R, Vargas EA, Santos M, Llorens R, Herreos J (1990) Neoadjuvant chemotherapy (NAC) with cisplatin (CDDP), mitomycin C (MMC) and vindesine (VDS) in locally advanced non small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 9: 227, A876
Fischer JR, Manegold C, Bülzebruck H, Vogt-Moykopf I, Drings P (1994) Induction chemotherapy with and without recombinant human granulocyte colony-stimulating factor support in locally advanced stage IIIA/B non-small cell lung cancer. Seminars in Oncology, Vol 21, No 3, Suppl 4 (June): pp 20–27
Takita H, Antkowiak J, Vaickus L, Driscoll D, Loewen G, Raghavan D (1993) Chemotherapy (PACC) and surgery in stage III NSCLC. Proc Am Soc Clin Oncol 12: 349A, 1172
Rebello J, Aramendia JM, Bilbao I, Herreros J, Aristu JJ, Azinovic I, FernandenzHidalgo 0 (1993) Neoadjuvant intra-arterial (IA chemotherapy for stage III non small cell lung cancer (NSCLC). Proc Am Soc Clin Ooncol 12: 346, A1161
Trybulla M, Taylor SG, Bonomi P (1985) Preoperative similtaneous cisplatin/5fluorouracil and radiotherapy in clinical stage III, non small cell bronchogenic carcinoma. Proc Am Soc Clin Oncol 4: 182, A710
Strauss G, Sherman D, Schwartz J (1986) Combined modality therapy for regionally advanced stage III non small cell carcinoma of the lung employing neoadjuvant chemotherapy, radiotherapy and surgery. Proc Am Soc Clin Oncol 5: 172, A675
Eagan RT, Ruud C, Lee R, Pairolero PC, Gail MH (1987) For the lung cancer study group: A pilot study of induction therapy with cyclophosphamide, doxorubicin, cis-platinum ( CAP) and chest irradiation prior to thoracotomy in initially inoperable stage III MO non small cell lung cancer. Cancer Treatm Rep 71: 895900
Pincus M, Reddy S, Lee MS, Bonomi P, Taylor IV S, Rowland K, Faber LP, Warren W, Kittle CF, Hendrickson FR (1988) Preoperative combined modality therapy for stage III MO non small cell lung carcinoma. Int J Radiation Oncology Biol Phys 15: 189–195
Skarin A, Jochelson M, Sheldon T, Malcom A, Oliynyk P, Overholt R, Hunt M (1989) Neoadjuvant chemotherapy in marginally in resectable stage III MO non small cell lung cancer Long-Term follow-up in 41 patients. J Surg Oncol 40: 266–274
Albain K, Rusch V, Crowley I, Griffin B, Beasley K, Livingston R (1991) Concurrent cisplatin (DDP), Vp-16, and chest irradiation (RT) followed by surgery for stages IIIa and IIIb non small cell lung cancer (NSCLC) A Southwest Oncology Groups (SWOG study (#8805). Proc Am Soc Clin Oncol 10: 244, A836
Weitberg AB, Yahar J, Glicksman AS, Posner A, Cummings F, Browne M, Clark J, Calabresi P, Beitz J, Murray C (1993) Combined modality therapy for stage III A non small cell carcinoma of the lung. Eur J Cancer 29A: 511–515
Sause W, Scott C, Taylor S, Johnson D, Livingston R, Komaki R, Emami B, Curran W, Byhardt R, Fisher B, Turrisi A (1994) RTOG 8808 ECOG 4588. Preliminary analysis of a phase II trial in regionally advanced unresectable non-small cell lung cancer. Proc ASCO 13: 325
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Drings, P., Wannenmacher, M. (1995). Nicht- Kleinzellige Bronchialkarzinome. In: Seeber, S., Schütte, J. (eds) Therapiekonzepte Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10494-1_18
Download citation
DOI: https://doi.org/10.1007/978-3-662-10494-1_18
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-58586-2
Online ISBN: 978-3-662-10494-1
eBook Packages: Springer Book Archive