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Kleinzellige Bronchialkarzinome

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Therapiekonzepte Onkologie

Zusammenfassung

Üblicherweise Anwendung findet die Klassifikation der WHO:

  • Haferzellkarzinom

  • Intermediärzellkarzinom

  • kombiniertes Haferzellkarzinom.

Ein Alternativvorschlag wurde von der IASLC (International Association for the Study of Lung Cancer) erarbeitet:

  • kleinzellig ohne Nachweis nichtkleinzelliger Anteile

  • kleinzellig mit großzelligen Anteilen

  • kleinzellig mit Adeno-und/oder Plattenepithelkarzinomanteilen.

Die einzelnen morphologischen Subtypen der WHO-Klassifikation weisen keine unterschiedliche Prognose auf. In der IASLC-Klassifikation soll die gemischt kleinzellig-großzellige Variante gegenüber der rein kleinzelligen mit einer ungünstigeren Prognose verbunden sein.

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Literatur

  1. Livingston RB, Moore TN, Heilbrun L et al. (1978) Smallcell carcinoma of the lung combined chemotherapy and radiation. A Southwest Oncology Group Study. Ann Int Med 88: 194–199

    Google Scholar 

  2. Niederle N, Krischke W, Schulz U et al. (1982) Untersuchungen zur kurzzeitigen Induktions-und zyklischen Erhaltungstherapie beim inoperablen kleinzelligen Bronchialkarzinom. Kli Wo 60: 829–838

    Article  CAS  Google Scholar 

  3. Aisner J, Whitacre M, VanEcho DA et al. (1982) Doxorubicin, Cyclophosphamide and VP16–23 ( ACE) in the Treatment of Small Cell Lung Cancer. Cancer Chemother Pharmacol 7: 187–193

    Google Scholar 

  4. Wolf M, Drings P, Hans K et al. (1991) Alternating chemotherapy with Adriamycin/Ifosfamide/Vincristin (AO) and either Cisplatin/Etoposide (PE) or Carboplatin/Etoposide (JE) in small cell lung cancer (SCLC). Lunc Cancer 7 (Suppl), abs 527: 141

    Google Scholar 

  5. Drings P, Bülzebruck H, Hruska D et al. (1986) EPICO für die Behandlung des kleinzelligen Bronchialkarzinoms. 3. Zwischenanalyse. Onkologie 9 (Suppl 1): 14–20

    Article  Google Scholar 

  6. Jett JR, Everson L, Thernau TM et al. (1990) Treatment of limited stage small-cell lung cancer with Cyclophosphamide, Doxorubicin and Vincristine with or without Etoposide: A Randomized et Trail of the North Central Cancer Treatment Group. J Clin Oncol 8: 33–38

    Google Scholar 

  7. Wolf M, Havemann K, Holle R et al. (1987) Cisplatin-Etoposide versus Ifosfamide/Etoposide combination chemotherapy in small cell lung cancer: A Multicenter German Randomized Trial. J Clin Oncol 5: 1880–1889

    Google Scholar 

  8. Wilke H, Achterrath W, Schmoll H-J et al. (1988) Etoposide and splitt-dose Cisplatin in small-cell lung cancer. Am J Clin Oncol 11 (5): 572–578

    Article  PubMed  CAS  Google Scholar 

  9. Jett JR, Su JQ, Maksymiuj AW et al. (1991) Phase III studies in the therapy of small cell lung cancer (SCLC): A North Central Cancer Treatment Group (NCCTG) Trial. Lung Cancer 7 (Suppl), abs 387: 106

    Google Scholar 

  10. Gatzemeier U, Hossfeld DK, Neuhaus R et al. (1992) Combinatin chemotherapy with Carboplatin, Etoposide and Vincristine as first-line treatment in small-cell lung cancer. J Clin Oncol 10: 818–823

    Google Scholar 

  11. Thatcher N, Lind M, Stout R et al. (1989) Carboplatin Ifosfamid and Etoposide with unid course vincristine and thoracic radiotherapy for limited stage small cell carcinoma of the bronchus. Br J Cancer 60: 98–101

    Article  PubMed  CAS  Google Scholar 

  12. Wolf M, Pritsch M, Drings P et al. (1991) Cyclic-alternating versus response-oriented chemotherapy in small-cell lung cancer: A German Multicenter Randomized Trial of 321 patients. J Clin Oncol 9: 614–624

    PubMed  CAS  Google Scholar 

  13. Giaccone G, Dalesio O, McVie GJ et al. (1993) Maintenance Chemotherapy in Small-Cell Lung Cancer: Long-Term Results of a Randomized Trial. J Clin Oncology 11: 1230–1240

    Google Scholar 

  14. Bleehen NM, Fayers PM, Girling DJ et al. (1989) Controlled trial of twelve versus six courses of chemotherapy in the treatment of small-cell lung cancer. Br J Cancer 59: 584–590

    Article  Google Scholar 

  15. Wolf M, Havemann K (1990) Alternierende Chemotherapie beim kleinzelligen Bronchialkarzinom. Onkologie 13: 157–164

    Article  PubMed  CAS  Google Scholar 

  16. Evans WE, Feld R, Murray N et al. (1987) Superiority of alternating non-crossresistant chemotherapy in extensive small cell lung cancer. Ann of Int Med 107: 451–458

    Article  CAS  Google Scholar 

  17. Feld R, Evans WK, Coy P et al. (1987) Canadien Multicenter Randomized Trial Comparing Sequential and Alternating Administration of two non-cross-resistant chemotherapy combinations in patients with limited small-cell carcinoma of the lung. J Clin Oncol 5: 1401–1409

    PubMed  CAS  Google Scholar 

  18. Johnson DH, Arriagada R, Ihde DC et al. (1992) Meta analysis of Randomized Trials Evaluating the Role of Thoracic Radiotherapy (TRT) in Limited-Stage (LD) Small Cell Lung Cancer ( SCLC ). Proceedings of ASCO 11: 288

    Google Scholar 

  19. Turrisi AT, Wagner H, Glover D et al. (1990) Limited small cell lung cancer (LSCLC): Concurrent bid thoracic radiotherapy (TRT) with Platinum/Etoposide (PE): An ECOG Study. Proceedings of ASCO 9, abs 887

    Google Scholar 

  20. Johnson DH, Turrisis AT, Chang AY et al. (1993) Alternating Chemotherapy and Twice-Daily Thoracic Radiotherapy in Limited-Stage Small-Cell Lung Cancer: A Pilot Study of the Eastern Cooperative Oncology Group. Journal of Clinical Oncology 11: 879–884

    Google Scholar 

  21. McCracken JD, Janaki LM, Crowley JJ et al. (1990) Concurrent Chemotherapy/ Radiochemotherapy for Limited Small-Cell Lung Carcinoma: A Southwest Oncology Group Study. Journal of Clinical Oncology 8: 892–898

    Google Scholar 

  22. Johnson DH, Kim K, Turrisi AT et al. (1994) Cisplatin (P)/Etoposide (E) + concurrent Thoracic Radiotherapy (TRT) adiministred once versus twice daily for limited stage (LS) small cell lung cancer (SCLC). Preliminary results of an intergroup trial Proc ASCO 13, p33, abs 1105

    Google Scholar 

  23. Murray N, Coy P, Pater JL et al. (1993) Importance of Timing for Thoracic Irradiation in the Combined Modality Treatment of Limited-Stage Small-Cell Lung Cancer. Journal of Clinical Oncology 11: 336–344

    PubMed  CAS  Google Scholar 

  24. Nielson OS, Fock K, Bentzen Set al. (1991) Timing of Radiotherapy and Chemotherapy in limited stage Small Cell Lung Cancer (LSCLC). Final Analysis EJC, Suppl 2, p 182, abs 1110

    Google Scholar 

  25. Arringada R, LeChevalier T, Borie F et al. (1994) Randomized trial on prophylactic cranial irradiation (PCI) for patients with small lung cancer in complete remission. Proc ASCO B, p 334, abs 1108

    Google Scholar 

  26. Ulsperger E, Karrer K, Denck H et al. (1991) Multimodality treatment for small cell bronchial carcinoma. European Journal of Cardiothoracic Surgery 5: 306–310

    Article  PubMed  CAS  Google Scholar 

  27. Schirren J, Krysa S, Bülzebruck H et al. (1991) Das kleinzellige Bronchialkarzinom — eine Operationsindikation? Z Herz-, Thorax-, Gefäßchir 5: 260–266

    Google Scholar 

  28. Lad T, Thomas P, Piantadosi S et al. (1991) Surgical Resection of small-cell lung cancer — A prospective randomized Evaluation. Lung Cancer 7 (Suppl): abs 604

    Google Scholar 

  29. Shepherd FA, Ginsberg RJ, Feld R et al. (1991) Surgical treatment for limited small-cell lung cancer. J Thorac Cardiovasc Surg 101: 385–395

    PubMed  CAS  Google Scholar 

  30. Miller PW, Earl HM, Sonhami RC et al. (1991) Intensive Weekly Chemotherapy for gott Prognosis Patients with Small Cell Lung Cancer. J Clin Oncol 9: 280-285

    Google Scholar 

  31. Miller DW, Spiro SG, Rudd RM et al. (1991) Interim Analysis of a randomized trial comparing 3 weekly versus weekly Chemotherapy in patients with small cell lung cancer. Lung Cancer 7 (Suppl), p 128, abs 476

    Google Scholar 

  32. Crawford J, Ozer H, Stoller R et al. (1991) Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer. N Eng J Med 325: 164–170

    Article  CAS  Google Scholar 

  33. Hamm JT, Schiller J, Oken MM et al. (1993) ?? Ranging study of recombinant Human Granulocyte-Macrophage Colony stimulating Faktor in small cell lung cancer. Proc ASCO 12, p 335, abs 1118

    Google Scholar 

  34. Havemann K, Klausmann M, Wolf Met al. (1991) Effekt of rhGM-CSF on hematopoietic reconstitution afer chemotherapy in small cell lung cancer. J Cancer Res Clin Oncol 117 (Suppl IV): 203–207

    Article  Google Scholar 

  35. Spitzer G, Farha P, Valdivieso M et al. (1986) High-Dose Intensification Therapy with Autologous Bone Marrow Support for Limited Small-Cell Bronchogenic Carcinoma. J Clin Oncology 4: 4–13

    CAS  Google Scholar 

  36. Elias AD, Ayash L, Wheeler C et al. (1992) High Dose Combinaton Alkylating Agents Supported by Autologous Marrow (ABMT) with Chest Radiotherapy for Responding Limited Stage (LD) Small Cell Lung Cancer. Proceedings of ASCO 11: abs 991

    Google Scholar 

  37. Bork E, Sigsgaard T, Nissen KM et al. (1991) Etoposide and Temiposide in untreated small cell lung cancer. Lung Cancer 7 (Suppl), p 121, abs 449

    Google Scholar 

  38. Morgan D, Gilson D, Fletcher J (1987) Vincristine and Etoposide. An effective chemotherapy regimen with reduced toxicity in extensive small cell lung cancer. Eur J Cancer Clin Oncol 23: 619–621

    Google Scholar 

  39. Sculier JP, Klastersky J, Libert P et al. (1990) A randomized study comparing etoposide and vindesine with or without cisplatin as induction therapy for small cell lung cancer. Annals of Oncology 1: 128–133

    PubMed  CAS  Google Scholar 

  40. Gatzmeier U, Heckmayr M, Neuhauss R et al. (1994) Chemotherapy of extensive small cell lung cancer — a randomized trial with carboplatin/etoposide/vincristine vs. etoposide/vincristine alone. J Cancer Res Clin Oncol 120 (Suppl) R24, 05.05. 05

    Google Scholar 

  41. Wolf M, Pritsch M, Drings P et al. (1994) Standard vs. palliative Chemotherapy in metastatic small cell lung cancer. An analysis of treatment efficacy and quality of life. Lung Cancer 1 (Suppl 1), p 92, abs 349

    Google Scholar 

  42. Hainsworth JD, Johnson D, Frazier SR, Greco A (1989) Chronic daily administration of oral Etoposide. A Phase I Trial J Clin Oncol 7: 396–401

    CAS  Google Scholar 

  43. Miller AA, Herudon J, Hollis D et al. (1994) Phase III Study of 21 day arol versus 3 day i.v. Etoposide in combination with Cisplatin in extensive small cell lung cancer. A CACGB Study. Proc aSCO 13, p326, abs 1974

    Google Scholar 

  44. Earl HM, Rudd RM, Spiro SG et al. (1991) A randomised trial of planned versus required chemotherapy in small cell lung cancer: a Cancer Research Campaign trial. Br J Cancer 64: 566–572

    Article  PubMed  CAS  Google Scholar 

  45. Murray N, Shad A, Osoba D et al. (1991) Intensive weekly chemotherapy for the Treatment of Extensive stage small cell lung cancer. J Clin Oncol 9: 1632–1638

    PubMed  CAS  Google Scholar 

  46. Mattson U, Niiranen A, Pyrhönen Set al. (1992) Natural Interferon Alfa as maintenance therapy for Small Cell Lung Cancer. Eur J Cancer 28: 1387–1391

    Article  Google Scholar 

  47. Kelly K, Bunn PA, Hazuka M et al. (1993) The role of alpha Interferon maintenance therapy in patients with limited stage SCLC responding to concurrent chemoradiotherapy. Proc ASCO p 320, abs 1092

    Google Scholar 

  48. Lebeau B, Chastang Ce et al. (1991) Subcutaneous heparin treatment increases complete response rate and overall survival in small cell lung cancer (SCLC). Lung Cancer 7 (Suppl), abs 480: 129

    Google Scholar 

  49. Maurer LH, Herudon JE, Hollis DR et al. (1993) A randomized trial for chemotherapy and radiation with or without werfarin for limited disease small cell lung cancer. Proc ASCO 12, p 335, abs 1119

    Google Scholar 

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© 1995 Springer-Verlag Berlin Heidelberg

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Wolf, M., Havemann, K. (1995). Kleinzellige Bronchialkarzinome. In: Seeber, S., Schütte, J. (eds) Therapiekonzepte Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10494-1_17

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  • DOI: https://doi.org/10.1007/978-3-662-10494-1_17

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