Abstract
When one considers the endometrium as a target for contraception, it is necessary to survey briefly what has been achieved heretofore, and how new knowledge has expanded the potential for development of antifertility agents which could specifically disrupt the implantation process. Until recently our understanding of the events occurring in the endometrium and the signaling between the developing embryo and the endometrium was scanty. Consequently the discovery of leads that might permit identification of agents to disrupt the implantation process was limited to hormonal and antihormonal compounds. Although the various hormonal and antihormonal approaches have merit, and one can envisage combination treatments being even more effective, they all have the potential problem of lack of specificity. Now that more specific factors controlling the implantation process are being uncovered, a path to the development of more specific implantation inhibitors appears possible.
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References
Anegon I, Cuturi MC, Godard A, Moreau M, Terqui M, Martinat-Botté F, Soulillou JP (1994) Presence of leukaemia inhibitory factor and interleukin 6 in porcine uterine secretions prior to conceptus attachment. Cytokine 6:493–499
Bany BM, Kennedy TG (1995) Interleukin-1α regulates prostaglandin production and cyclooxygenase activity in sensitized rat endometrial stromal cells in vitro. Biol Reprod 53:126–132
Bhatt H, Brunet LJ, Stewart CL (1991) Uterine expression of leukemia inhibitory factor coincides with the onset of blastocyst implantation. Proc Natl Acad Sci USA 88:11408–11412
Braga VMM, Gendler SJ (1993) Modulation of Muc-1 mucin expression in the mouse uterus during the estrus cycle, early pregnancy and placentation. J Cell Sci 105:397–405
Charnock-Jones DS, Sharkey AM, Fenwick P, Smith SK (1994) Leukemia inhibitory factor mRNA concentration peaks in human endometrium at the time of implantation and the blastocyst contains mRNA for the receptor at this time. J Reprod Fertil 101:421–426
Chen D-B, Hilsenrath R, Yang Z-M, Le S-P, Kim S-R, Chuong CJ, Poindexter AN III, Harper MJK (1995a) Leukaemia inhibitory factor in human endometrium during the menstrual cycle: cellular origin and action on production of glandular epithelial cell prostaglandin in vitro. Hum Reprod 10:911–918
Chen D-B, Yang Z-M, Hilsenrath R, Le S-P, Harper MJK (1995b) Stimulation of prostaglandin (PG) F2α and PGE2 release by tumour necrosis factor-α and interleukin-1α in cultured human luteal phase endometrial cells. Hum Reprod 10:2773–2780
De M, Sandford TR, Wood GW (1993) Expression of interleukin 1, interleukin 6 and tumor necrosis factor a in mouse uterus during the peri-implantation period of pregnancy. J Reprod Fertil 97:83–89
Dower SK, Kronheim SR, Hopp TP, Cantrell M, Deeley M, Gillis S, Henney CS, Urdal DL (1986) The cell surface receptors for interleukin-1α and interleukin-1β are identical. Nature 324:266–268
Fazleabas AT, Hild-Petito S, Verhage HG (1994) Secretory proteins and growth factors of the baboon (Papio anubis) uterus: potential roles in pregnancy. Cell Biol Intl 18:1145–1153
Feldman B, Poueymirou W, Papaioannou VE, DeChiara TM, Goldfarb M (1995) Requirement of FGF-4 for postimplantation mouse development. Science 267:246–249
Frank GR, Brar AK, Jikihara H, Cedars MI, Handwerger S (1995) Interleukin-1β and the endometrium: an inhibitor of stromal cell differentiation and possible autoregulator of decidualization in humans. Biol Reprod 52:184–191
Fukuda MN, Sato T, Nakayama J, Klier G, Mikami M, Aoki D, Nozawa S (1995) Trophinin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation. Genes Dev 9:1199–1210
Gearing DP, Thut CJ, VandenBos T, Gimpel SD, Delaney PB, King J, Price V, Cosman D, Beckmann MP (1991) Leukemia inhibitory factor is structurally related to the IL-6 signal transducer, gpl30. EMBO J 10:239–248
Gearing DP, Comeau MR, Friend DJ, Gimpel SD, Thut CJ, McGourty J, Brasher KK, King JA, Gillis S, Mosley B, Ziegler SF, Cosman D (1992) The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. Science 255:1434–1437
Hamilton JA, Waring PM, Filonzi EL (1993) Induction of leukemia inhibitory factor in human synovial fibroblasts by IL-1 and tumor necrosis factor-α. J Immunol 150:1496–1502
Hatayama H, Kanzaki H, Iwai M, Kariya M, Fujimoto M, Higuchi T, Kojima K, Nakayama H, Mori T, Fujita J (1994) Progesterone enhances macrophage colony-stimulating factor production in human endometrial stromal cells in vitro. Endocrinology 135:1921–1927
Hilton DJ, Nicola NA, Metcalf D (1991) Distribution and comparison of receptors for leukemia inhibitory factor on murine hemopoietic and hepatic cells. J Cell Physiol 146:207–215
Hirano T, Matsuda T, Nakajima K (1994) Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily. Stem Cells 12:262–277
Horseman ND, Yu-Lee L-Y (1994) Transcriptional regulation by the helix bundle peptide hormones: growth hormone, prolactin and hematopoietic cytokines. Endocr Rev 15:627–649
Hunt JS, Chen H-L, Hu X-L, Pollard JW (1993) Normal distribution of tumor necrosis factor-α messenger ribonucleic acid and protein in the uteri, placentas, and embryos of osteopetrotic (op/op) mice lacking colony-stimulating factor-1. Biol Reprod 49:441–452
Ilesanmi AO, Hawkins DA, Lessey BA (1993) Immunohistochemical markers of uterine receptivity in the human endometrium. Microsc Res Technique 25:208–222
Inoue T, Kanzaki H, Iwai M, Imai K, Narukawa S, Higuchi T, Katsuragawa H, Mori T (1994) Tumor necrosis factor a inhibits in-vitro decidualization of human endometrial stromal cells. Hum Reprod 9:2411–2417
Ip NY, Nye SH, Boulton TG, Davis S, Taga T, Li Y, Birren SJ, Yasukawa K, Kishimoto T, Anderson DJ, Stahl N, Yancopoulos GD (1992) CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell 69:1121–1132
Jacobs AL, Carson DD (1993) Uterine epithelial cell secretion of interleukin-1α induces prostaglandin E2 (PGE2) and PGF2α secretion by uterine stromal cells in vitro. Endocrinology 132:300–308
Jentoft N (1990) Why are proteins O-glycosylated? Trends Biochem Sci 15:291–294
Jikihara H, Handwerger S (1994) Tumor necrosis factor-α inhibits the synthesis and release of human decidual cell prolactin. Endocrinology 134:353–357
Kariya M, Kanzaki H, Hanamura T, Imai K, Narukawa S, Inoue T, Hatayama H, Mori T (1994) Progesterone-dependent secretion of macrophage colony-stimulating factor by human endometrial stromal cells of nonpregnant uterus in culture. J Clin Endocrinol Metab 79:86–90
Kauma S, Matt D, Strom S, Eierman D, Turner T (1990) Interleukin-1β (IL-1β), human leukocyte antigen HLA-DR α, and transforming growth factor-β (TGF-β) expression in endometrium, placenta and placental membranes. Am J Obstet Gynecol 163:1430–1436
Kimber SJ (1994) Carbohydrates as low affinity binding agents involved in initial attachment of the mammalian embryo at implantation. In: Ward RHT, Smith SK, Donnai D (eds) Early fetal growth and development. Royal College of Obstetricians and Gynecologists Press, London, pp 75–102
Kimber SJ, Illingworth IM, Glasser SR (1995) Expression of carbohydrate antigens in the rat uterus during early pregnancy and after ovariectomy and steroid replacement. J Reprod Fertil 103:75–87
Kliman HJ, Feinberg RF, Schwartz LB, Feinman MA, Lavi E, Meaddough EL (1995) A mucin-like glycoprotein identified by MAG (mouse ascites golgi) antibodies. Menstrual cycle-dependent localization in human endometrium. Am J Pathol 146:166–181
Kojima K, Kanzaki H, Iwai M, Hatayama H, Fujimoto M, Inoue T, Horie K, Nakayama H, Fujita J, Mori T (1994) Expression of leukemia inhibitory factor in human endometrium and placenta. Biol Reprod 50:882–887
Kwun JK, Emmens CW (1974) Hormone requirements for implantation and pregnancy in the ovariectomized rabbit. Aust J Biol Sci 27:275–283
Lessey BA (1994) The use of integrins for the assessment of uterine receptivity. Fertil Steril 61:812–814
Lessey BA, Damjanovich L, Coutifaris C, Castelbaum A, Albelda SM, Buck CA (1992) Integrin adhesion molecules in the human endometrium. Correlation with the normal and abnormal menstrual cycle. J Clin Invest 90:188–195
Lessey BA, Castelbaum AJ, Buck CA, Lei Y, Yowell CW, Sun J (1994) Further characterization of endometrial integrins during the menstrual cycle and in pregnancy. Fertil Steril 62:497–506
Lord KA, Abdollahi A, Thomas SM, DeMarco M, Brugge JS, Hoffman-Lie-bermann B, Liebermann DA (1991) Leukemia inhibitory factor and inter-leukin-6 trigger the same immediate early response, including tyrosine phosphorylation, upon induction of myeloid leukemia differentiation. Mol Cell Biol 11:4371–4379
Lütticken C, Wegenka UM, Yuan J, Buschmann J, Schindler C, Ziemiecki A, Harpur AG, Wilks AF, Yasukawa K, Taga T, Kishimoto T, Barbieri G, Pellegrini S, Sendtner M, Heinrich PC, Horn F (1994) Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science 263:89–92
Murakami M, Narazaki M, Hibi M, Yawata H, Yasukawa K, Hamaguchi M, Taga T, Kishimoto T (1991) Critical cytoplasmic region of the interleukin-6 signal transducer gp130 is conserved in the cytokine receptor family. Proc Natl Acad Sci USA 88:11349–11353
Murakami M, Hibi M, Nakagawa N, Nakagawa T, Yasukawa K, Yamanishi Y, Taga T, Kishimoto T (1993) Il-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 260:1808–1810
Nakajima K, Wall R (1991) Interleukin-6 signals activating junB and tis11 gene transcription in a B-cell hybridoma. Mol Cell Biol 11:1409–1418
Oppenheim JJ, Kovacs EJ, Matsushima K, Durum SK (1986) There is more than one interleukin-1. Immunol Today 7:45–56
Ornitz DM, Herr AB, Nilsson M, Westman J, Svahn C-M, Waksman G (1995) FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides. Science 268:432–436
Piquet-Pellorce C, Grey L, Mereau A, Heath JK (1994) Are LIF and related cytokines functionally equivalent? Exp Cell Res 213:340–347
Pollard JW, Hunt JS, Wiktor-Jedrzejczak W, Stanley ER (1991) A pregnancy defect in the osteopetrotic (op/op) mouse demonstrates the requirement for CSF-1 in female fertility. Dev Biol 148:273–283
Psychoyos A (1974) Hormone control of ovo-implantation. Vitam Horm 32:201–256
Rathjen PD, Toth S, Willis A, Heath JK, Smith AG (1990) Differentiation inhibition activity is produced in matrix associated and soluble forms that are generated by alternate promoter usage. Cell 62:1105–1114
Robertson SA, Mayrhofer G, Seamark RF (1992) Uterine epithelial cells synthesize granulocyte-macrophage colony stimulating factor and interleukin-6 in pregnant and non-pregnant mice. Biol Reprod 46:1069–1079
Rodan SB, Wesolowski G, Hilton DJ, Nicola NA, Rodan GA (1990) Leukemia inhibitory factor binds with high affinity to preosteoblastic RCT-1 cells and potentiates the retinoic acid induction of alkaline phosphatase. Endocrinology 127:1602–1608
Rose TM, Bruce AG (1991) Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin-6. Proc Natl Acad Sci USA 88:8641–8645
Schultz JF, Armant DR (1995)β1- and β3-class integrins mediate fibronectin binding activity at the surface of developing mouse peri-implantation blastocysts. J Biol Chem 270:11522–11531
Shen MM, Leder P (1992) Leukemia inhibitory factor is expressed by the pre-implantation uterus and selectively blocks primitive ectoderm formation in vitro. Proc Natl Acad Sci USA 89:8240–8244
Sheth KV, Roca GL, Al-Sedairy ST, Parhar RS, Hamilton CJCM, Al-Abdul Jabbar F (1991) Prediction of successful embryo implantation by measuring interleukin-1α and immunosuppressive factor(s) in preimplantation embryo culture fluid. Fertil Steril 55:952–957
Simón C, Piquette GN, Frances A, Westphal LM, Heinrichs WL, Polan ML (1993a) Interleukin-1 type I receptor messenger ribonucleic acid (mRNA) expression in human endometrium throughout the menstrual cycle. Fertil Steril 59:791–796
Simón C, Piquette GN, Frances A, Polan ML (1993b) Localization of interleukin-1 type I receptor and interleukin-1β in human endometrium throughout the menstrual cycle. J Clin Endocrinol Metab 77:549–555
Simón C, Frances A, Piquette GN, El-Danasouri I, Zurawski G, Dang W, Polan ML (1994) Embryonic implantation in mice is blocked by interleukin-1 receptor antagonist. Endocrinology 134:521–528
Stahl N, Boulton TG, Faruggella T, Ip NY, Davis S, Witthun BA, Quelle FW, Silvennoinen O, Barbieri G, Pellegrini S, Ihle JN, Yancopoulos GD (1994) Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6β receptor components. Science 263:92–95
Stahl N, Faruggella T, Boulton TG, Zhong Z, Darnell JE Jr, Yancopoulos GD (1995) Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267:1349–1353
Stewart CL, Kaspar P, Brunet LJ, Bhatt H, Gadi I, Köntgen F, Abbondanzo SJ (1992) Blastocyst implantation depends on maternal expression of leukemia inhibitory factor. Nature 359:76–79
Strous GJ, Dekker J (1992) Mucin-type glycoproteins. Crit Rev Biochem Mol Biol 27:57–92
Surveyor GA, Gendler SJ, Pemberton L, Das SK, Chakraborty I, Julian J, Pi-mental RA, Wegner CC, Dey SK, Carson DD (1995) Expression and steroid hormonal control of Muc-1 in the mouse uterus. Endocrinology 136:3639–3647
Tabibzadeh S, Kaffka KL, Satyaswaroop PG, Kilian PL (1990) Interleukin-1 (IL-1) regulation of human endometrial function: presence of IL-1 receptor correlates with IL-1-stimulated prostaglandin E2 production. J Clin Endocrinol Metab 70:1000–1006
Tang X-M, Rossi MJ, Masterson BJ, Chegini N (1994) Insulin-like growth factor I (IGF-I), IGF-I receptors, and IGF binding proteins 1–4 in human uterine tissue: tissue localization and IGF-I action in endometrial stromal and myometrial smooth muscle cells in vitro. Biol Reprod 50:1113–1125
Taniguchi T (1995) Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268:251–255
Tartakovsky B, Ben-Yair E (1991) Cytokines modulate preimplantation development and pregnancy. Dev Biol 146:345–352
Tomida M, Yamamoto-Yamaguchi Y, Hozumi M, Holmes W, Lowe DG, Goed-del DV (1990) Inhibition of development of (Na+)-dependent hexose transport in renal epithelial LLC-PK1 cells by differentiation-stimulating factor for myeloid leukemia cells/leukemia inhibitory factor. FEBS Lett 268:261–264
Williams RL, Hilton DJ, Pease S, Willson TA, Stewart CL, Gearing DP, Wagner EF, Metacalf D, Nicola NA, Gough NM (1988) Myeloid leukemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 336:684–687
Willson TA, Metcalf D, Gough NM (1992) Cross-species comparison of the sequence of the leukaemia inhibitory factor gene and its protein. Eur J Bio-chem 204:21–30
Yamamoto-Yamaguchi Y, Tomida M, Hozumi M (1986) Specific binding of a factor inducing differentiation to mouse myeloid leukemic M1 cells. Exp Cell Res 164:97–102
Yang Z-M, Le S-P, Chen D-B, Harper MJK (1994) Temporal and spatial expression of leukemia inhibitory factor in rabbit uterus during early pregnancy. Mol Reprod Dev 38:148–152
Yang Z-M, Chen D-B, Le S-P, Harper MJK (1995a) Interleukin-1α in the rabbit uterus during early pregnancy. Early Pregn Biol Med 1:201–205
Yang Z-M, Le S-P, Chen D-B, Cota J, Siero V, Yasukawa K, Harper MJK (1995b) Leukemia inhibitory factor (LIF), LIF receptor and gp130 in the mouse uterus during early pregnancy. Mol Reprod Dev 42:407–414
Yang Z-M, Le S-P, Chen D-B, Yasukawa K, Harper M.J.K. (1995c) Expression patterns of leukemia inhibitory factor receptor (LIFR) and the gp130 receptor component in rabbit uterus during early pregnancy. J Reprod Fertil 103:249–255
Yang Z-M, Chen D-B, Le S-P, Harper MJK (1996a) Differential hormonal regulation of leukemia inhibitory factor (LIF) in rabbit and mouse uterus. Mol Reprod Dev 43:470–476
Yang Z-M, Chen D-B, Le S-P, Brown RW, Chuong CJ, Harper MJK (1996b) Localization of leukemia inhibitory factor in human endometrium during the menstrual cycle. Early Pregn Biol Med 2:18–22
Zhang Z, Funk C, Roy D, Glasser SR, Mulholland J (1994a) Heparin-binding epidermal growth factor-like growth factor is differentially regulated by progesterone and estradiol in rat uterine epithelial and stromal cells. Endocrinology 134:1089–1094
Zhang Z, Funk C, Glasser SR, Mulholland J (1994b) Progesterone regulation of heparin-binding epidermal growth factor-like factor gene expression during sensitization and decidualization in the rat uterus: effects of the antipro-gestin ZK 98.299. Endocrinology 135:1256–1263
Zhong Z, Wen Z, Darnell JE Jr (1994) Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264:95–98
Zolti M, Ben-Rafael Z, Meirom R, Shemesh M, Bider D, Mashiach S, Apte R (1991) Cytokine involvement in oocytes and early embryos. Fertil Steril 56:265–272
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Harper, M.J.K. (1997). Cytokines and Their Receptors in the Peri-implantation Endometrium. In: Beier, H.M., Harper, M.J.K., Chwalisz, K. (eds) The Endometrium as a Target for Contraception. Ernst Schering Research Foundation Workshop, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10323-4_5
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