Pharmacokinetics of Tacrolimus Ointment: Clinical Relevance



Atopic dermatitis is a common inflammatory skin disease whose pathophysiology is not completely understood. Evidence now strongly points to a role for T cells and their cytokines in many phases of atopic dermatitis. Both immediate and delayed hypersensitivity seem to be involved, although how they intertwine remains a complex issue. Th2 cells appear most important in the early stages of atopic lesion development, as their cytokines (IL-4, IL-5 and IL-13) induce eosinophil proliferation and IgE production. The binding of allergen to IgE on mast cells triggers the release of mast cell mediators. When allergen-IgE complexes attach to the FCεRI and FCεRII receptors on Langerhans cells, the magnitude of the response is multiplied.


Stratum Corneum Systemic Exposure Area Under Curve Atopic Dermatitis Patient Severe Atopic Dermatitis 
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