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Human Hepatitis Delta Virus: an Agent with Similarities to Certain Satellite RNAs of Plants

  • Chapter
Satellites and Defective Viral RNAs

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 239))

Abstract

One of the most intriguing aspects of hepatitis delta virus (HDV) is that, even though it is a naturally occurring infectious agent of human beings, it nevertheless shows a number of remarkable similarities to viroids, the subviral agents of plants that are considered elsewhere in this volume. The recognition and exploitation of this analogy has been a major contributor to studies of HDV genome replication. This review will concentrate on the structure of the HDV genome and the mechanism by which the genome is replicated, with special emphasis on similarities to the viroids. The review will not consider in any depth other important aspects of HDV, such as the assembly of genomes into virus particles, experimental transmission, host responses, or epidemiology. For such information the reader is directed to other more extensive reviews (Lai 1995; Purcell and Gerin 1996; Hadziyannis 1997; Margolis et al. 1997). However, to put this review in perspective, we will present a limited amount of background material.

J.T. was supported by grants AI-26522 and CA-06927 from the N.I.H. and by an appropriation from the Commonwealth of Pennsylvania

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Authors and Affiliations

  1. Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA, 19111, USA

    J. M. Taylor

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  1. J. M. Taylor
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Editors and Affiliations

  1. Division of Oncovirology, Mail Drop & Room BCC239, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA

    Peter K. Vogt Ph.D.

  2. Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, 94720, USA

    Andrew O. Jackson Ph.D.

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© 1999 Springer-Verlag Berlin Heidelberg

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Taylor, J.M. (1999). Human Hepatitis Delta Virus: an Agent with Similarities to Certain Satellite RNAs of Plants. In: Vogt, P.K., Jackson, A.O. (eds) Satellites and Defective Viral RNAs. Current Topics in Microbiology and Immunology, vol 239. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09796-0_6

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  • DOI: https://doi.org/10.1007/978-3-662-09796-0_6

  • Publisher Name: Springer, Berlin, Heidelberg

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  • Online ISBN: 978-3-662-09796-0

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