Abstract
Multiple site experiments [1] have led to a new theoretical approach for ET beyond the single-pathway picture [2, 3, 4]. This approach emphasizes tubes — tightly grouped families of pathways — and looks for interactions between these families, rather than focussing on individual paths. In some cases, for a given donor D and acceptor A, the electron transfer can be thought of as “pathway-like”, wherein the protein bridge can be physically reduced to a tube without changing the overall coupling. In other cases, the transfer is characterized by multiple tubes which can interfere with one another, and a single path assumption will fail to identify all of the structural elements which control the coupling. Reducing the protein to only the relevant parts (tubes) that mediate the tunneling matrix element is a useful tool for understanding ET in a biological medium.
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Regan, J.J., Onuchic, J.N. (1996). A Tubular View of Electron Transfer in Azurin. In: Bicout, D., Field, M. (eds) Quantum Mechanical Simulation Methods for Studying Biological Systems. Centre de Physique des Houches, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09638-3_7
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