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P1 Receptors

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Book cover Purinergic and Pyrimidinergic Signalling I

Part of the book series: Purinergic and Pyrimidinergic Signalling ((HEP,volume 151 / 1))

Abstract

Adenosine is an endogenous nucleoside, present in all cells and body fluids, that modulates a wide variety of physiological processes. In their seminal paper, Drury and Szent-Györgyi (1929) showed that adenosine and other adenine nucleotides could modulate cardiovascular system function. Over the following 70 years, specific receptors for adenosine were pharmacologically characterized and eventually cloned and a number of selective agonists and antagonists identified (Ralevrc and Burnstock 1998; Abbracchio and Williams, Chap. 1, this volume; Jacobson and Knutsen, Chap. 6, this volume). Four G-protein-coupled heptahelical receptors (GPCRs) sensitive to adenosine constitute the Pl receptor family and these are designated A1, A2A A2B, and A3 (Fredholm et al. 1994) (Fig. 1).

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  1. A. Lorenzen
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  2. U. Schwabe
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  1. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133, Milan, Italy

    Maria Pia Abbracchio

  2. Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Searle 8-477 (S-215), 303 East Chicago Avenue, 60611, Chicago, IL, USA

    Michael Williams

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Lorenzen, A., Schwabe, U. (2001). P1 Receptors. In: Abbracchio, M.P., Williams, M. (eds) Purinergic and Pyrimidinergic Signalling I. Purinergic and Pyrimidinergic Signalling, vol 151 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09604-8_2

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