Toxicology of Glucosidase Inhibitors

  • E. M. Bomhard
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 119)


A large number of toxicity studies have been performed on the general and reproduction toxicology, genotoxicity and carcinogenicity of acarbose. Besides the usual guideline studies required by the international authorities for registration, several special studies have also been initiated to clarify the effects that were observed in the original long-term study of acarbose in rats and which were of questionable relevance for the clinical situation. Some of these results have been published in previous articles (Schlüter1982a, 1988).


Dose Level Leydig Cell Body Weight Gain Leydig Cell Tumour Carcinogenicity Study 
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© Springer-Verlag Berlin Heidelberg 1996

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  • E. M. Bomhard

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