Pathophysiology of Type 2 Diabetes Mellitus

  • A. J. Scheen
  • P. J. Lefèbvre
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 119)


Non-insulin-dependent diabetes mellitus (NIDDM), also called type 2 diabetes mellitus, is a common metabolic disorder that afflicts 2%–5% of the adult population of most Western countries, with, however, wide international variation (King et al. 1993). Furthermore, NIDDM is often undiagnosed even in the Western countries (Hortulanus-Beck et al. 1990), and numerous data indicate that undiagnosed NIDDM is not a benign condition (Harris 1993). Certainly, NIDDM is a leading cause of disability and death in developed and developing nations (Songer 1992).


Insulin Resistance Insulin Secretion Hepatic Glucose Production NIDDM Patient Muscle Glycogen Synthesis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • A. J. Scheen
  • P. J. Lefèbvre

There are no affiliations available

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