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Physicochemical Properties and Analytical Methods of Determination of Biguanides

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Book cover Oral Antidiabetics

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 119))

Abstract

As described by Shapiro et al. (1959), biguanides are diacid bases. They have a particularly strong primary dissociation constant and a considerably weaker second dissociation constant. The first salts of biguanides which were prepared were the sulfate (obtained by treatment of the biguanide-copper complex), the hydrochloride and the nitrate because of its insolubility. Other known salts are the toluenesulfonate, the tartrate and the pamoate. In order to obtain a better pharmacological activity some other salts have been prepared by treating biguanides with carboxylic acids. These salts were the adamantate, Clofibrate, orotate, nicotinate, isoxazole-carboxylate, pyrazole-carboxylate, trimethoxybenzoate and 4-chlorophenoxyacetate.

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Authors
  1. E. Prugnard
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  2. M. Noel
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Editors and Affiliations

  1. Institut für Klinische Pharmakologie, Bayer AG, Aprather Weg, 42096, Wuppertal, Germany

    Jochen Kuhlmann

  2. Krummacher Straße 200, 42115, Wuppertal, Germany

    Walter Puls

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© 1996 Springer-Verlag Berlin Heidelberg

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Prugnard, E., Noel, M. (1996). Physicochemical Properties and Analytical Methods of Determination of Biguanides. In: Kuhlmann, J., Puls, W. (eds) Oral Antidiabetics. Handbook of Experimental Pharmacology, vol 119. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09127-2_11

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  • DOI: https://doi.org/10.1007/978-3-662-09127-2_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-62456-1

  • Online ISBN: 978-3-662-09127-2

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