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The Advantages and Limitations of Cell Culture as a Model of Bone Formation

  • Conference paper
Novel Approaches to Treatment of Osteoporosis

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 25))

  • 79 Accesses

Abstract

Despite its rather unglamorous image, bone is a remarkably complex and versatile organ, the correct functioning of which is essential for our general health. Bone formation comprises a complex but ordered sequence of events, beginning with the proliferation of chondrogenic and osteogenic precursor cells followed by their subsequent differentiation, ultimately leading to extracellular matrix (ECM) maturation and mineralization. Under normal circumstances, this process is tightly controlled by a combination of the endocrine system and locally acting growth factors. Bone can also respond to physical stimuli and removal of this stimulus, as experienced by astronauts in zero gravity or by patients undergoing extended bed-rest, results in a net loss of bone. Sometimes, the mechanisms controlling bone growth are defective, e.g., in nonunion of fractures and osteoporosis. Sometimes bone development is defective, as in achondroplasia, caused by a lack of chondrocytes in the growth plates of long bones resulting in short limbs, or gigantism, which is due to the failure of the growth plates to fuse at puberty allowing the bones to grow throughout life.

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Authors
  1. K. Dobson
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  2. S. Jones
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  3. P. Liu
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  4. D. Miao
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  5. L. Reading
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  6. C. Shui
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  7. K. Still
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  8. A. Scutt
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Editor information

Editors and Affiliations

  1. Human Metabolism and Clinical Biochemistry, Sheffield University Medical School, Beech Hill Road, S 10 2RX, Sheffield, UK

    R. Graham G. Russell

  2. Department of Biology, University of York, PO Box 373, YO1 5YW, York, UK

    Timothy M. Skerry

  3. FC/HT Research, Schering AG, Müllerstr. 178, 13342, Berlin, Germany

    Uwe Kollenkirchen

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© 1998 Springer-Verlag Berlin Heidelberg

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Dobson, K. et al. (1998). The Advantages and Limitations of Cell Culture as a Model of Bone Formation. In: Russell, R.G.G., Skerry, T.M., Kollenkirchen, U. (eds) Novel Approaches to Treatment of Osteoporosis. Ernst Schering Research Foundation Workshop, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09007-7_1

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  • DOI: https://doi.org/10.1007/978-3-662-09007-7_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-09009-1

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