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Neuropsychologie der Aufmerksamkeitsdefizit-Hyperaktivitäts-Störung

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Neuropsychologie psychischer Störungen

Zusammenfassung

Mit der Gestalt des letzten deutschen Kaisers scheinen Historiker auch heute noch zu ringen. Seine Ausstrahlung war groß, seine schnelle Auffassungsgabe, sein gutes Gedächtnis, sein Charme und seine rednerische Begabung machten ihn in jedem Kreise bald zum Wortführer. Leider galt das auch für Gespräche mit Fachleuten, welche ihm Vortrag halten sollten. Zu dieser bedenklichen Neigung trat seine Ruhelosigkeit, seine Impulsivität, sein Mangel an Konzentration, sein Bedürfnis nach Abwechslung und Unterhaltung, sein mangelnder Takt und die fehlende Menschenkenntnis (Ries 1998, S. 820).

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Literatur

  • Aman CJ, Roberts RJ, Pennington BF (1998) A neuropsychological examination of the underlying deficit in Attention deficit hyperactivity disorder: Frontal lobe versus right parietal lobe theories. Develop Psychol 34: 956–969

    Article  CAS  Google Scholar 

  • American Psychiatric Association (APA) (1994) Diagnostic and statistical manual of mental disorders, 4th edn. Author, Washington/DC

    Google Scholar 

  • Arnsten AF, Steere JC, Hunt RD (1996) The contribution of az noradrenergic mechanisms of prefrontal cortical cogni- tive function. Potential significance for attention-deficit hyperactivity disorder. Arch Gen Psychiatry 53: 448–455 Barkley RA (1997) Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psycho) Bull 121: 65–94. Bei dieser Übersichtsarbeit versucht einer der führenden amerikanischen ADHDForscher die »Theorielosigkeit« vieler empirischer Studien zu ADHD zu überwinden, indem er basierend auf drei älteren neuropsychologischen Theorien ein Modell der ADHD vorschlägt, bei dem die Inhibitionsstörung mit Defiziten in vier exekutiven Bereichen, nämlich a) dem Arbeitsgedächtnis b) der Selbstregulation des affektiv-motivationalen Arousals c) der Internalisierung der Sprache und d) der Rekonstitution (behaviorale Analyse und Synthese) einhergeht. Barkley versucht empirische Studien als Beleg für seine Theorie anzuführen, die allerdings nicht immer einer kritischen Diskussion standhalten können. Allerdings liefert dieser Artikel die Möglichkeit überprüfbare Hypothesen abzuleiten und somit längerfristig zu einem besseren Störungsverständnis der ADHD beizutragen.

    Google Scholar 

  • Bizot JC, Thiebot MH (1996) Impulsivity as a confounding factor in certain animal tests of cognitive function. Cogn Brain Res 3: 243–250

    Article  CAS  Google Scholar 

  • Berquin PC, Giedd JN, Jacobsen LK, Hamburger SD, Krain AL, Rapoport JL, Castellanos FX (1994) Cerebellum in attention-deficit hyperactivity disorder: a morphometric MRI study. Neurology 50: 1087–1093

    Article  Google Scholar 

  • Bush G, Frazier JA, Rauch SL et al. (1999) Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the Counting Stroop. Biol Psychiatry 45: 1542–1552

    Article  PubMed  CAS  Google Scholar 

  • Cabeza R, Nyberg L (2000) Imaging cognition II: An empirical review of 275 PET and fMRI studies. J Cogn Neurosci 12: 1–47

    Article  PubMed  CAS  Google Scholar 

  • Carter CS, Krener, P, Chaderjian M, Northcutt C, Wolfe V (1995) Asymmetrical visual-spatial attentional performance in ADHD: evidence for a right hemispheric deficit. Biol Psychiatry 37: 789–797

    Article  PubMed  CAS  Google Scholar 

  • Casey BJ, Castellanos FX, Giedd JN et al. (1997) Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 36: 374–383

    Article  PubMed  CAS  Google Scholar 

  • Castellanos FX, Giedd JN, Berquin PC et al. (2001) Quantitative brain magnetic resonance imaging in girls with attentiondeficit/hyperactivity disorder. Arch Gen Psychiatry 58: 289–295

    Article  PubMed  CAS  Google Scholar 

  • Clarke AR, Barry kJ, McCarthy R, Selikowitz M (1998) EEG analysis in attention-deficit/hyperactivity disorder: a comparative study of two subtypes. Psychiatry Res 81: 19–29

    Article  PubMed  CAS  Google Scholar 

  • Conners CK, Sitarenios G, Parker JD, Epstein JN (1998) The revised Conners’ Parent Rating Scale (CPRS-R): factor structure, reliability, and criterion validity. J Abnorm Child Psycho) 26: 257–268

    Article  CAS  Google Scholar 

  • Crystal DS, Ostrander R, Chen RS, August GJ (2001) Multi-method assessment of psychopathology among DSMIV subtypes of children with attention-deficit/hyperactivity disorder: self-, parent, and teacher reports. J Abnorm Child Psycho) 29: 189–205

    Article  CAS  Google Scholar 

  • Döpfner M, Lehmkuhl G (1998) Diagnostik-System für psychische Störungen im Kindes-und Jugendalter nach ICD-10 und DSM-IV. Huber, Bern

    Google Scholar 

  • DeWolfe NA, Byrne JM, Bawden FIN (1999) Early clinical assess- ment of attention. Clin Neuropsychol 13: 458–473

    Article  PubMed  CAS  Google Scholar 

  • Dilling H, Mombour W, Schmidt MH (1991) Internationale Klassifikation psychischer Störungen. ICD-10 Kapitel V ( F). Huber, Bern

    Google Scholar 

  • DuPaul GJ, Barkley RA, McMurray MB (1994) Response of children with ADHD to methylphenidate: interaction with internalizing symptoms. J Am Acad Child Adolesc Psychiatry 33: 894–903

    Article  PubMed  CAS  Google Scholar 

  • Epstein JN, Johnson DE, Varia IM, Conners CK (2001) Neuro-psychological assessment of response inhibition in adults with ADHD. J Clin Exp Neuropsychol 23: 362–371

    Article  PubMed  CAS  Google Scholar 

  • Ernst M, Zametkin, Ai, Matochik 1A, Jons PH, Cohen RM (1998) Presynaptic dopaminergic activity in ADHD adults. A [fluorine-18] fluorodopa positron emission tomographic study. J Neurosci 18: 5901–5907

    CAS  Google Scholar 

  • Faraone SV, Biederman J (1998) Neurobiology of attention-deficit hyperactivity disorder. Biol Psychiatry 44: 951–958

    Article  PubMed  CAS  Google Scholar 

  • Gainetdinov RR, Wetsel WC, Jones SR, Levin ED, Jaber M, Caron MG (1999) Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science 283: 397–401

    Article  PubMed  CAS  Google Scholar 

  • Gallagher R, Blader J (2001) The diagnosis and neuropsychological assessment of adult attention deficit/hyperactivity disorder. Scientific study and practical guidelines. Ann N Y Acad Sci 931: 148–171

    Google Scholar 

  • Glowinski J, Besson MJ, Cheramy A (1984) Role of the thalamus in the bilateral regulation of dopaminergic and GABAergic neurons in the basal ganglia. Ciba Found Symp 107: 150–163

    PubMed  CAS  Google Scholar 

  • Gray JA (1982) The neuropsychology of anxiety. Oxford University Press, New York

    Google Scholar 

  • Greenhill LL, Halperin JM, Abikoff H (1999) Stimulant medica- tions. J Am Acad Child Adolesc Psychiatry 38: 503–512

    Article  PubMed  CAS  Google Scholar 

  • Herpertz SC, Wenning B, Mueller B, Qunaibi M, Sass H, Herpertz-Dahlmann B (2001) Psychophysiological responses in ADHD boys with and without conduct disorder: implications for adult antisocial behavior. J Am Acad Child Adolesc Psychiatry 40: 1222–1230

    Article  PubMed  CAS  Google Scholar 

  • Hoffmann H (1844) Der Struwwelpeter: oder lustige Geschichten and drollige Bilder für Kinder von 3–6 Jahren. Rutten and Loning, Frankfurt/M

    Google Scholar 

  • Jensen PS, Martin D, Cantwell DP (1997) Comorbidity in ADHD: implications for research, practice, and DSM-V.1 Am Acad Child Adolesc Psychiatry 36: 1065–1079

    Article  CAS  Google Scholar 

  • Jensen PS (2001) Introduction-ADHD comorbidity and treatment outcomes in the MTA. J Am Acad Child Adolesc Psychiatry 40: 134–136

    Article  PubMed  CAS  Google Scholar 

  • Jonkman LM, Kemner C, Verbaten MN et al. (1999) Perceptual and response interference in children with attention-deficit hyperactivity disorder, and the effects of methylphenidate. Psychophysiology 36: 419–429

    Article  PubMed  CAS  Google Scholar 

  • Klorman R (1991) Cognitive event-related potentials in atten- tion-deficit disorders. J Learn Disabil 12: 130–140

    Article  Google Scholar 

  • Konrad K, Gauggel S, Manz A, Scholl M (2000) Inhibitory control in children with traumatic brain injury (TBI) and children with attention deficit/hyperactivity disorder ( ADHD ). Brain Inj 14: 859–875

    Google Scholar 

  • Kuhne M, Schachar R, Tannock R (1997) Impact of comorbid oppositional or conduct problems on attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 36: 1715–1725

    Article  PubMed  CAS  Google Scholar 

  • Logan, GD (1994) On the ability to inhibit thought and action: A user’s guide to the stop signal paradigma. In: Dagenbach D, Carr TH (eds) Inhibitory processes in attention, memory, and language. Academic Press, San Diego/CA, pp 189–239

    Google Scholar 

  • Matochik JA, Nordahl TE, Gross M, Semple WE, King AC, Cohen RM, Zametkin Al (1993) Effects of acute stimulant medication on cerebral metabolism in adults with hyperactivity. Neuropsychopharmacology 8: 377–386

    Article  PubMed  CAS  Google Scholar 

  • Matochik JA, Liebenauer LL, King CC, Szymanski HV, Cohen RM, Zametkin, AJ (1994) Cerebral glucose metabolism in adults with ADHD after chronic stimulant treatment. Am J Psychiatry 151: 658–664

    PubMed  CAS  Google Scholar 

  • Mefford IN, Potter WZ (1989) A neuroanatomical and biochemical basis for attention deficit disorder with hyperactivity in children: a defect in tonic adrenaline mediated inhibition of locus coeruleus stimulation. Med Hypotheses 29: 33–42

    Article  PubMed  CAS  Google Scholar 

  • Murphy K, Barkley RA (1995) Updated adult norms for the ADHD behavior checklist in adults. ADHD Report 4: 12–16

    Google Scholar 

  • Nigg JT (2001) Is ADHD a disinhibitory disorder? Psycho) Bull 127: 571–598. Diese Arbeit stellt eine sehr gelungene Übersichtsarbeit aller neuerer empirischer Untersuchungen zur Inhibition bei Patienten mit ADHD dar. Neben der Darstellung einer Taxonomie von verschiedenen Inhibitions formen und einer entsprechenden Einordnung einer Vielzahl kognitiver Paradigmen zur Inhibition, liefert der Artikel darüber hinaus interessante Überlegungen zu den Fragen, ob die Inhibitionsstörung primärer oder sekundärer Natur sind und welchen Einfluss komorbide Störungen und Subtypen auf die Inhibitionsdefizite haben. Der Autor gibt ferner viele konkrete Vorschläge für weitergehende empirische Studien, die für das Ätiologieverständnis der ADHD relevant sein könnten.

    Google Scholar 

  • Nigg JT, Swanson J, Hinshaw SP (1997) Covert visual attention in boys with attention deficit hyperactivity disorder: Lateral effects, methylphenidate response, and results for parents. Neuropsychologia 35: 165–176

    Google Scholar 

  • National Institutes of Health Consensus Development Conference Statement (NH) (2000) Diagnosis and treatment of attention-deficit/hyperactivity disorder (ADHD). J Am Acad Child Adolesc Psychiatry 39: 182–193

    Article  Google Scholar 

  • Oosterlaan J, Logan GD, Sergeant JA (1998) Response Inhibition in AD/HD, CD, comorbid AD/HD + CD, anxious, and control children: A meta-analysis of studies with the stop task. J Child Psychol Psychiatry Allied Discipl 39: 411–425

    Google Scholar 

  • Oosterlaan J, Logan GD, Sergeant JA (1998) Response Inhibition in AD/HD, CD, comorbid AD/HD + CD, anxious, and control children: A meta-analysis of studies with the stop task. J Child Psycho) Psychiatry Allied Discipl 39: 411–425

    Google Scholar 

  • Pennington BF, Ozonoff S (1996) Executive functions and developmental psychopathology. J Child Psycho) Psychiatry 37: 51–87

    Article  CAS  Google Scholar 

  • Oosterlaan J, Sergeant JA (1998) Effects of reward and response cost on response inhibition in AD/HD, disruptive, anxious, and normal children. J Abnorm Child Psycho) 26: 161–174

    Article  CAS  Google Scholar 

  • Pliszka SR (2000) Patterns of psychiatric comorbidity with attention-deficit/hyperactivity disorder. Child Adolesc Psychiatr Clin North Am 9: 525–540

    CAS  Google Scholar 

  • Pliszka SR, McCracken JT, Maas JW (1996) Catecholamines in attention-deficit hyperactivity disorder: Current perspectives. J Am Acad Child Adolesc Psychiatry 35: 264–271

    Google Scholar 

  • Posner MI, Raichle ME (1994) Networks of attention. In: Posner MI, Raichle ME (eds) Images of mind. Scientific American Library, New York, pp 153–179 )

    Google Scholar 

  • Quay HC (1988) The behavioral reward and inhibition system in childhood behavior disorders. In: Bloomingdale LM (ed) Attention deficit disorder: New research in attention, treatment and psychopharmacology, vol 3. Pergamon Press, Oxford/UK, pp 176–185

    Google Scholar 

  • Quist JF, Kennedy JL (2001) Genetics of childhood disorders. ADHD, Part 7, The Serotonin System. J Am Acad Child Adolesc Psychiatry 40: 253–256

    Google Scholar 

  • Ries H (1998) Das hyperkinetische Syndrom Kaiser Wilhelms II. Der Kinderarzt 29: 820–822

    Google Scholar 

  • Rubia K, Overmeyer S, Taylor E, Brammer M, Williams SC, Simmons A, Bullmore ET (1999) Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: a study with functional MRI. Am J Psychiatry 156: 891–896

    PubMed  CAS  Google Scholar 

  • Sanders AF (1983) Towards a model of stress and performance. Acta Psycho) 53: 51–97

    Google Scholar 

  • Schachar R (1991) Childhood hyperactivity. 1 Child Psycho) Psychiatry 32: 155–191

    Article  CAS  Google Scholar 

  • Schachar R, Tannock R, Logan G (1993) Inhibitory control, impulsiveness, and attention deficit hyperactivity disorder. Clin Psycho) Rev 13: 721–739

    Article  Google Scholar 

  • Schaughency EA, Lahey BB, Hynd GW, Stone PA, Piacentini JC, Frick PJ (1989) Neuropsychological test performance and the attention deficit disorders: clinical utility of the Luria-Nebraska Neuropsychological Battery-Children’s Revision. J Consult Clin Psycho) 57: 112–116

    Article  CAS  Google Scholar 

  • Sergeant JA (2000) The cognitive-energetic model: an empirical approach to ADHD. Neurosci Biobehav Rev 24: 7–12

    Article  PubMed  CAS  Google Scholar 

  • Shenker A (1992) The mechanism of action of drugs used to treat attention-deficit hyperactivity disorder: focus on catecholamine receptor pharmacology. Adv Pediatr 39: 337–382

    PubMed  CAS  Google Scholar 

  • Smalley SL, Bailey JN, Palmer CG et al. (1998) Evidence that the dopamine D4 receptor is a susceptibility gene in attention deficit hyperactivity disorder. Mol Psychiatry 3: 427–430

    Article  PubMed  CAS  Google Scholar 

  • Solanto MV (1984) Neuropharmacological basis of stimulant drug action in attention deficit disorder with hyperactivity: a review and synthesis. Psycho) Bull 95: 387–409

    Article  CAS  Google Scholar 

  • Solanto MV (2000) Clinical psychopharmacology of AD/HD: Implications for animal models. Neurosci Biobehav Rev 24: 27–30

    Article  PubMed  CAS  Google Scholar 

  • Sonuga-Barke EJ (1995) Disambiguating inhibitory dysfuntion in childhood hyperactivity. In: Sergeant J (ed) Eunethydis: European approaches to hyperkinetic disorder. Fotorar, Zürich, pp 209–223

    Google Scholar 

  • Sonuga-Barke EJ, Saxton T, Hall M (1998) The role of interval underestimation in hyperactive children’s failure to suppress responses over time. Behav Brain Res 94: 45–50

    Article  PubMed  CAS  Google Scholar 

  • Speltz ML, DeKlyen M, Calderon R, Greenberg MT, Fisher PA (1999) Neuropsychological characteristics and test behaviors of boys with early onset conduct problems. J Abnorm Psychol 108: 315–325

    Article  PubMed  CAS  Google Scholar 

  • Spencer T, Biederman J, Wilens T, Harding M, O’Donnell D, Griffin S (1996) Pharmacotherapy of attention-deficit hyperactivity disorder across the life cycle. 1 Am Acad Child Adolesc Psychiatry 35: 409–432

    Article  CAS  Google Scholar 

  • Sprague RL, Sleator EK (1977) Methylphenidate in hyperkinetic children: differences in dose effects on learning and social behavior. Science 198: 1274–1276

    Article  PubMed  CAS  Google Scholar 

  • Still GF (1902) Some abnormal psychical conditions in children. Lancet, pp 1077–1082

    Google Scholar 

  • Strandburg RJ, Marsh JT, Brown WS, Asarnow RF, Higa J, Harper R, Guthrie D (1996) Continuous-processing-related event-related potentials in children with attention deficit hyperactivity disorder. Biol Psychiatry 40: 964–980

    Article  PubMed  CAS  Google Scholar 

  • Swanson J, Oosterlaan, J, Murias M et al. (2000a) Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention. Proc Natl Acad Sci U S A 97: 4754–4759

    Article  PubMed  CAS  Google Scholar 

  • Swanson JM, Flodman P, Kennedy J et al. (2000b) Dopamine genes and ADHD. Neurosci Biobehav Rev 24: 21–25

    Article  PubMed  CAS  Google Scholar 

  • Tannock R, Schachar RJ, Logan GD (1995) Methylphenidate and cognitive flexibility: dissociated dose effects in hyperactive children. J Abnorm Child Psychol 23: 235–266

    Article  PubMed  CAS  Google Scholar 

  • Thapar A, Harrington R, McGuffin P (2001) Examining the co-morbidity of ADHD-related problems using a twin study design. Br J Psychiatry 179: 224–229

    Article  PubMed  CAS  Google Scholar 

  • Vaidya CJ, Austin G, Kirkorian G (1998) Selective effects of methylphenidate in attention deficit hyperactivity disorder: A functional magnetic resonance study. Proc Natl Acad Sci U S A 95: 14494–14499. Bei dieser Arbeit handelt es sich um die erste Studie, die im Rahmen einer kognitiven Aktivierungsaufgabe Veränderungen unter Methylphenidat (MPH) bei Kindern mit Hilfe der funktionellen Bildgebung untersucht hat. Dabei wurde MPH interessanterweise nicht nur den ADHD-Kindern sondern auch gesunden Kontrollkindern verabreicht. Auch wenn diese ethisch nicht unumstrittene Studie somit lediglich Aufschluss über akute und nicht über chronische MPH-Effekte liefert zeigte sich dennoch als äußerst interessantes Ergebnis, dass trotz homologer Veränderung auf der Verhaltensebene bei Kindern mit ADHD und gesunden Kindern, sich unterschiedliche Aktivierungsveränderungen unter MPH ergaben. So verbesserte sich die inhibitorische Leistung im Go-No-Go-Task und im fMRI zeigte sich eine gleich starke Zunahme der frontalen Aktivierung in beiden Gruppen, wohingegen die striatale Aktivierung bei den gesunden Kindern unter MPH ab-, bei den ADHD-Kindern zunahm. Somit bestätigte sich durch diese Untersuchung, die sicherlich noch weiterer Replikationen bedarf, dass ADHD assoziiert ist mit atypischen frontostriatalen Aktivierungen. Es ergaben sich erste Hinweise darauf, dass MPH die striatale Aktivierung bei gesunden und ADHD-Kindern unterschiedlich beeinflusst.

    Google Scholar 

  • Van der Meere J, Vreeling Hi, Sergeant J (1992) A motor presetting study in hyperactive, learning disabled and control children. J Child Psycho) Psychiatry 33: 1347–1354

    Article  Google Scholar 

  • Van der Meere J, Wekking E, Sergeant) (1991) Sustained attention and pervasive hyperactivity. J Child Psycho) Psychiatry 32: 275–284

    Article  Google Scholar 

  • Van der Meere J, Gunning B, Stemerdink N (1999) The effect of methylphenidate and clonidine on response inhibition and state regulation in children with ADHD. J Child Psychos Psychiatry 40: 291–298

    Article  Google Scholar 

  • Volkow ND, Wang GJ, Fowler JS et al. (1999) Blockade of stria-tal dopamine transporters by intravenous methylphenidate is not sufficient to induce self-reports of »high«. J Pharmacol Exp Ther 288: 14–20

    PubMed  CAS  Google Scholar 

  • World Health Organization (WHO) (1993) The ICD-10 classification of mental and behavioral disorders: Diagnostic criteria for research. Author, Genf

    Google Scholar 

  • Zappitelli M, Pinto T, Grizenko N (2001) Pre-, peri-, and postnatal trauma in subjects with attention-hyperactivity disorder. Can J Psychiatry 46: 542–548

    PubMed  CAS  Google Scholar 

  • Zimmermann P, Fimm B (1993) Testbatterie zur Aufmerksamkeitsprüfung (TAP) Version 1.02c, Handbuch Teil 1. Psytest

    Google Scholar 

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Konrad, K., Herpertz-Dahlmann, B. (2004). Neuropsychologie der Aufmerksamkeitsdefizit-Hyperaktivitäts-Störung. In: Lautenbacher, S., Gauggel, S. (eds) Neuropsychologie psychischer Störungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08959-0_19

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