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Methodik klinischer Studien pp 121–146Cite as

Meta-Analyse randomisierter klinischer Studien, Publikations-Bias und Evidence-Based Medicine

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Part of the book series: Statistik und ihre Anwendungen ((STATIST))

Zusammenfassung

Randomisierte klinische Studien sind ein wichtiges Mittel für die Erkenntnisgewinnung in der medizinischen Forschung; ihre Ergebnisse bilden die Grundlage für eine evidenzbasierte Medizin (Evidence-Based Medicine; EBM). Dabei spielt die Zusammenfassung der Ergebnisse mehrerer Studien zur gleichen Fragestellung im Rahmen von Meta-Analysen eine immer wichtigere Rolle. Bezieht sich eine solche Meta-Analyse nur auf publizierte Studien, so kann ihr Ergebnis sehr stark davon abhängen, inwieweit alle zur Fragestellung durchgeführten Studien auch tatsächlich publiziert wurden. Dieses, als Publikations-Bias bezeichnete Phänomen muss bei der kritischen Bewertung der Ergebnisse von Meta-Analysen unbedingt beachtet werden. In diesem Kapitel wird diese Problematik in leicht verständlicher Form und am Beispiel von konkreten Studien diskutiert. Gleichzeitig wird auf das Prinzip der evidenzbasierten Medizin und die Rolle der Cochrane Collaboration hingewiesen.

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Authors
  1. Guido Schwarzer
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  2. Daniel Galandi
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  3. Gerd Antes
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  4. Martin Schumacher
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© 2002 Springer-Verlag Berlin Heidelberg

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Schwarzer, G., Galandi, D., Antes, G., Schumacher, M. (2002). Meta-Analyse randomisierter klinischer Studien, Publikations-Bias und Evidence-Based Medicine. In: Methodik klinischer Studien. Statistik und ihre Anwendungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08719-0_8

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  • DOI: https://doi.org/10.1007/978-3-662-08719-0_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-43306-4

  • Online ISBN: 978-3-662-08719-0

  • eBook Packages: Springer Book Archive

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