Abstract
Khat, Catha edulis (Vahl) Forssk. ex Endl. (Celasteraceae), is an evergreen shrub or tall tree that may reach up to 25 m in height if not pruned (Fig. 1). Extensive pruning makes it a small shrub, as it is usually described. Its life span may extend for 40 years. The plant is indigenous to East Africa and southern Arabia, but may have originated in the Harar district of Ethiopia, according to earlier reports (Getahun and Krikorian 1973). Its habitat extends from northern Ethiopia to the mountainous regions of East Africa and Yemen, all the way to south Africa, between latitudes 18 °N and 30 °S. It is cultivated mostly on hillsides and mountain slopes at altitudes of 1500–2000 m above sea level (Nordal 1980; Krikorian 1984). Besides Ethiopia and Yemen, the khat plant is now grown in Djibouti, Somalia, Kenya, Tanzania, Uganda, and Madagascar. However, the use of the plant is by no means restricted to the natives of these countries, but extends to other Asian countries and immigrant communities in several Western countries (Kalix 1990).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Al-Meshal I, Ageel AM, Parmar NS, Tariq M (1985) Cat ha edulis (Khat): use, abuse and current status of scientific knowledge. Fitoterapia 56: 131
Baxter R, Crombie L, Simmonds D, Whiting D, Braenden O, Szendrei K (1979) Alkaloids of Catha edulis (khat). Isolation and characterization of eleven new alkaloids with sesquiterpene cores (cathedulins). J Chem Soc Chem Commun 1979: 2965–2971
Butler LG (1989) Sorghum polyphenols. In: Cheeke PR (ed) Toxicants of plant origin, vol IV. Phenolics. CRC Press, Boca Raton, pp 95–121
Duke JA (1985) Handbook of medicinal herbs. CRC Press, Boca Raton
Eddy N, Halbach H, Isbell H, Seevers M (1965) Drug dependence: its significance and characteristics. Bull WHO 32: 721–733
El-Domiaty MM, Elhag HM, El-Feraly FS, Al-Meshal IA, El-Olemy MM (1994) Studies on (—)-cathinone formation in micropropagated plants and tissue cultures of Catha edulis (Khat). Int J Pharmacog (2): 135–141
Elhag HM (1991) In vitro propagation of Catha edulis. HortSci 26 (2): 212
Elmi A (1983b) The chewing of khat in Somalia. J Ethnopharmacol 8: 163–176
Gamborg OL, Miller RA, Ojima K (1968) Nutrient requirements of suspension cultures of soybean root cells. Exp Cell Res 50: 151–158
Geisshusler S, Brenneisen R (1987) The content of physcoactive phenylpropyl-and phenylpentenylkhatamines in Catha edulis Forsk. of different origin. J Ethnopharmacol 19: 269–277
Getahun A, Krikorian A (1973) Chat: coffee’s rival from Harar, Ethiopia. 1. Botany, cultivation and use. Econ Bot 27: 353–377.
Halbach H (1972) Medical aspects of the chewing of khat leaves. Bull WHO 7: 21–29
Kalix P (1990) Pharmacological properties of the stimulant khat. Pharmacol Ther 48: 397–416
Krikorian A (1984) Khat and its use: a historical perspective. J Ethnopharmacol 12: 115–178 Luqman W, Danowski T (1976) The use of khat in Yemen: social and medical observations. Ann Intern Med 85: 246–249
Morton JF (1979) Plant tannins and esophageal cancer, In: Deichmann W (ed) Toxicology and occupational medicine (Proc 10th Inter-Amer Conf on Toxicology and occupational medicine). Elsevier, North Holland, Amsterdam, pp 129–137
Morton, JF (1989) Tannin as a carcinogen in bush-tea: tea, mate and khat. In: Hemingway RW Karchesy JJ (eds) Chemistry and significance of condensed tannins. Plenum, New York, pp 403–416
Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15: 473–497
Nordal A (1980) Khat: pharmacognostical aspects. Bull Narc 32: 51–64
Nordal A, Laane MM (1978) Identification of khat. MEDD, Norsk Farm, Selsk 40: 1–18
Petereit F, Kolodziej H, Nahrstedt A (1991) Flavan-3-OLS and proanthocyanidins from Cistus incanus. Phytochemistry 30 (3): 981–985
Qureshi S, Al-Meshal I, Tariq M, Ageel A, Shah A (1989) Effect of khat on spermatozoa from the different stages of spematogenic cycle in mice. Fitoterapia 60: 257–259
Shadan P, Shellard EJ (1962) An anatomical study of Ethiopian khat (leaf of Catha edulis. Forsk ). J Pharm Pharmacol 14: 110–118
Tariq M, Bacchus R, Moaz A, Sobki S, Rafatullah S, Al-Meshal IA (1993) Reproductive toxicity of khat (Catha edulis): a substance of abuse from eastern Africa and the Arabian Peninsula. In: Richardson M (ed) Reproductive toxicology. Weinheim, New York, pp 231–244
United Nations Document (1975) Investigations on the phenylalkylamine fraction, MNAR/11 United Nations Document (1977) Substances isolated from khat. MNAR/7. United Nations Narcotics Laboratory, GE. 77–4507
United Nations Narcotics Laboratory (1978) The botany and chemistry of khat. Report of an Expert group. Antanarivo, 27 Nov.-1 Dec. 1978. MNAR/3 GE. 79–10365
World Health Organization (1964) Expert Committee on Addiction-Producing Drugs. Khat. WHO Techn Rep Ser 273: 10
World Health Organization (1980) W.H.O. Advisory Group. Review of the pharmacology of khat. Bull Narc 32: 89–93
World Health Organization W.H.O. (1985) Expert Committee on Addiction-Producing Drugs. Khat. WHO Techn Rep Ser 729: 8–9
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Elhag, H.M., Mossa, J.S. (1996). Catha edulis (Khat): In Vitro Culture and the Production of Cathinone and Other Secondary Metabolites. In: Bajaj, Y.P.S. (eds) Medicinal and Aromatic Plants IX. Biotechnology in Agriculture and Forestry, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08618-6_5
Download citation
DOI: https://doi.org/10.1007/978-3-662-08618-6_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-08229-0
Online ISBN: 978-3-662-08618-6
eBook Packages: Springer Book Archive