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Molecular Epidemiology in Cancer Prevention

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Mechanisms in Carcinogenesis and Cancer Prevention

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 156))

Abstract

A major goal of cancer epidemiology is to provide evidence from population-based studies for the implementation of public health measures to reduce cancer morbidity and mortality. Molecular epidemiology provides laboratory-based tools with which to better achieve this goal. The types of laboratory measure incorporated into cancer epidemiology are varied and include measures of environmental or endogenous exposures, genetic or other host factors influencing susceptibility to disease and surrogate markers for the disease itself. The measurement of these biological events (“biomarkers”), which are on or related to the carcinogenic pathway, can contribute to primary, secondary, and tertiary cancer prevention strategies (Fig. 1).

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References

  • Allan JM, Wild CP, Rollinson S, Willett EV, Moorman AV, Dovey GJ, Roddam PL, Roman E, Cartwright RA, Morgan GJ (2001) Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia, Proc Natl Acad Sci USA 98:11592–11597

    Article  PubMed  CAS  Google Scholar 

  • Allen SJ, Wild CP, Wheeler JG, Riley EM, Montesano R, Bennett S, Whittle HC, Hall AJ (1992) Aflatoxin exposure malaria and hepatitis B infection in rural Gambian children, Trans R Soc Trop Med Hyg 86:426–430

    Article  PubMed  CAS  Google Scholar 

  • Anderson LM, Diwan BA, Fear NT, Roman E (2000) Critical windows of exposure for children’s health: cancer in human epidemiological studies and neoplasms in experimental animal models, Environ Health Perspect 108 Suppl 3:573–594

    Google Scholar 

  • Anker P, Mulcahy H, Chen XQ, Stroun M (1999) Detection of circulating tumor DNA in the blood (plasma/serum) of cancer patients, Cancer Metastasis Rev 18:65–73

    Article  PubMed  CAS  Google Scholar 

  • Bani-Hani K, Martin IG, Hardie LJ, Mapstone N, Briggs JA, Forman D, Wild CP (2000) Prospective study of cyclin Dl overexpression in Barrett’s esophagus: association with increased risk of adenocarcinoma, J Natl Cancer Inst 92:1316–1321

    Article  PubMed  CAS  Google Scholar 

  • Bonadona V, Saltel P, Desseigne F, Mignotte H, Saurin JC, Wang Q, Sinilnikova O, Giraud S, Freyer G, Plauchu H, Puisieux A, Lasset C (2002) Cancer patients who experienced diagnostic genetic testing for cancer susceptibility: reactions and behavior after the disclosure of a positive test result, Cancer Epidemiol Bio-markers Prev 11:97–104

    Google Scholar 

  • Bonassi S, Hagmar L, Stromberg U, Montagud AH, Tinnerberg H, Forni A, Heikkila P, Wanders S, Wilhardt P, Hansteen IL, Knudsen LE, Norppa H (2000) Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens. European Study Group on Cytogenetic Biomarkers and Health, Cancer Res 60:1619–1625

    PubMed  CAS  Google Scholar 

  • Bottorff JL, Ratner PA, Balneaves LG, Richardson CG, McCullum M, Hack T, Chalmers K, Buxton J (2002) Women’s interest in genetic testing for breast cancer risk: the influence of sociodemographics and knowledge, Cancer Epidemiol Biomarkers Prev 11:89–95

    PubMed  Google Scholar 

  • Castelao JE, Yuan JM, Skipper PL, Tannenbaum SR, Gago-Dominguez M, Crowder JS, Ross RK, Yu MC (2001) Gender- and smoking-related bladder cancer risk, J Natl Cancer Inst 93:538–545

    Article  PubMed  CAS  Google Scholar 

  • Chemin I, Ohgaki H, Chisari FV, Wild CP (1999) Altered expression of hepatic carcinogen metabolizing enzymes with liver injury in HBV transgenic mouse lineages expressing various amounts of hepatitis B surface antigen, Liver 19:81–87

    Article  PubMed  CAS  Google Scholar 

  • Chen SY, Chen CJ, Chou SR, Hsieh LL, Wang LY, Tsai WY, Ahsan H, Santella RM (2001) Association of aflatoxin B(l)-albumin adduct levels with hepatitis B surface antigen status among adolescents in Taiwan, Cancer Epidemiol Biomarkers Prev 10:1223–1226

    PubMed  CAS  Google Scholar 

  • Egner PA, Wang JB, Zhu YR, Zhang BC, Wu Y, Zhang QN, Qian GS, Kuang SY, Gange SJ, Jacobson LP, Helzlsouer KJ, Bailey GS, Groopman JD, Kensler TW (2001) Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer, Proc Natl Acad Sci USA 98:14601–14606

    Article  PubMed  CAS  Google Scholar 

  • Greaves MF (1997) Aetiology of acute leukaemia, Lancet 349:344–349

    Article  PubMed  CAS  Google Scholar 

  • Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis, Cancer Res 54:4855–4878

    PubMed  CAS  Google Scholar 

  • Groopman JD, Kensler TW (1999) The light at the end of the tunnel for chemical-specific biomarkers: daylight or headlight?, Carcinogenesis 20:1–11

    Article  PubMed  CAS  Google Scholar 

  • Hall AJ, Wild CP (1992) Aflatoxin Biomarkers. Lancet 339:1413–1414

    Article  PubMed  CAS  Google Scholar 

  • Hayashi S, Watanabe J, Kawajiri K (1992) High susceptibility to lung cancer analyzed in terms of combined genotypes of P450IA1 and Mu-class glutathione S-transferase genes, Jpn J Cancer Res 83:866–870

    Article  PubMed  CAS  Google Scholar 

  • Herbst AL, Ulfelder H, Poskanzer DC (1971) Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women, N Engl J Med 284:878–881

    Article  PubMed  CAS  Google Scholar 

  • IARC (1990) Cancer: Causes, Occurence and Control Tomatis L, ed. IARC Scientific Publications No 100, IARC, Lyon, France

    Google Scholar 

  • IARC (2001) Biomarkers in Cancer Chemoprevention Miller AB, Bartsch H, Boffetta P, Dragsted L, Vainio H, eds., IARC Scientific Publications No 154, Lyon, France

    Google Scholar 

  • Jackson PE, Qian GS, Friesen MD, Zhu YR, Lu P, Wang JB, Wu Y, Kensler TW, Vogelstein B, Groopman JD (2001) Specific p53 mutations detected in plasma and tumors of hepatocellular carcinoma patients by electrospray ionization mass spectrometry, Cancer Res 61:33–35

    PubMed  CAS  Google Scholar 

  • Jacobson LP, Zhang BC, Zhu YR, Wang JB, Wu Y, Zhang QN, Yu LY, Qian GS, Kuang SY, Li YF, Fang X, Zarba A, Chen B, Enger C, Davidson NE, Gorman MB, Gordon GB, Prochaska HJ, Egner PA, Groopman JD, Munoz A, Helzlsouer KJ, Kensler TW (1997) Oltipraz chemoprevention trial in Qidong, People’s Republic of China: study design and clinical outcomes, Cancer Epidemiol Biomarkers Prev 6:257–265

    PubMed  CAS  Google Scholar 

  • Jankowski JA, Harrison RF, Perry I, Balkwill F, Tselepis C (2000) Barrett’s metaplasia, Lancet 356:2079–2085

    Article  PubMed  CAS  Google Scholar 

  • Jernstrom H, Lerman C, Ghadirian P, Lynch HT, Weber B, Garber J, Daly M, Olopade OI, Foulkes WD, Warner E, Brunet JS, Narod SA (1999) Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2, Lancet 354:1846–1850

    Article  PubMed  CAS  Google Scholar 

  • Judah DJ, Hayes JD, Yang JC, Lian LY, Roberts GC, Farmer PB, Lamb JH, Neal GE (1993) A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an antioxidant, Biochem J 292:13–18

    PubMed  CAS  Google Scholar 

  • Kelloff GJ, Sigman CC, Hawk ET, Johnson KM, Crowell JA, Guyton KZ (2001) Surrogate end-point biomarkers in chemopreventive drug development, in Biomarkers in Cancer Chemoprevention, Miller AB, Bartsch H, Boffetta P, Dragsted L, Vainio H, eds., IARC Scientific Publications No 154, Lyon, France pp 13–26

    Google Scholar 

  • Kensler TW, Gange SJ, Egner PA, Dolan PM, Munoz A, Groopman JD, Rogers AE, Roebuck BD (1997) Predictive value of molecular dosimetry: individual versus group effects of oltipraz on aflatoxin-albumin adducts and risk of liver cancer, Cancer Epidemiol Biomarkers Prev 6:603–610

    PubMed  CAS  Google Scholar 

  • Kensler TW, He X, Otieno M, Egner PA, Jacobson LP, Chen B, Wang JS, Zhu YR, Zhang BC, Wang JB, Wu Y, Zhang QN, Qian GS, Kuang SY, Fang X, Li YF, Yu LY, Prochaska HJ, Davidson NE, Gordon GB, Gorman MB, Zarba A, Enger C, Munoz A, Helzlsouer KJ, et al. (1998) Oltipraz chemoprevention trial in Qidong, People’s Republic of China: modulation of serum aflatoxin albumin adduct biomarkers, Cancer Epidemiol Biomarkers Prev 7:127–134

    PubMed  CAS  Google Scholar 

  • Kensler TW, Groopman JD, Sutter TR, Curphey TJ, Roebuck BD (1999) Development of cancer chemopreventive agents: oltipraz as a paradigm, Chem Res Toxicol 12:113–126

    Article  PubMed  CAS  Google Scholar 

  • Kihara M, Noda K (1994) Lung cancer risk of GSTM1 null genotype is dependent on the extent of tobacco smoke exposure, Carcinogenesis 15:415–418

    Article  PubMed  CAS  Google Scholar 

  • Kirby GM, Chemin I, Montesano R, Chisari FV, Lang MA, Wild CP (1994) Induction of specific cytochrome P450s involved in aflatoxin Bl metabolism in hepatitis B virus transgenic mice, Mol Carcinog 11:74–80

    Article  PubMed  CAS  Google Scholar 

  • Kirk GD, Camus-Randon AM, Mendy M, Goedert JJ, Merle P, Trepo C, Brechot C, Hainaut P, Montesano R (2000) Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia, J Natl Cancer Inst 92:148–153

    Article  PubMed  CAS  Google Scholar 

  • Lebailly P, Kane EV, Moorman AV, Roman E, Morgan GJ, Wild CP (2002) Genetic polymorphisms in microsomal epoxide hydrolase and CYP2E1 and susceptibility to adult acute myeloid leukaemia with respect to specific cytogenetic abnormalities. Br. J Haem 116, 587–594

    Article  CAS  Google Scholar 

  • Luan JA, Wong MY, Day NE, Wareham NJ (2001) Sample size determination for studies of gene-environment interaction. Int J Epid 30:1035–1040

    Article  CAS  Google Scholar 

  • Maclure M, Bryant MS, Skipper PL, Tannenbaum SR (1990) Decline of the hemoglobin adduct of 4-aminobiphenyl during withdrawal from smoking, Cancer Res 50:181–184

    PubMed  CAS  Google Scholar 

  • Montesano R, Hainaut P, Wild CP (1997) Hepatocellular carcinoma: from gene to public health, J Natl Cancer Inst 89:1844–1851

    Article  PubMed  CAS  Google Scholar 

  • Moorman AV, Roman E, Willett EV, Dovey GJ, Cartwright RA, Morgan GJ (2001) Karyotype and age in acute myeloid leukemia. Are they linked?, Cancer Genet Cytogenet 126:155–161

    Article  PubMed  CAS  Google Scholar 

  • Muller FH (1939) Tabakmissbrauch und lungencarcinom, Zeitschrift fur Krebsforschung 49:57–85

    Article  Google Scholar 

  • Peluso M, Airoldi L, Magagnotti C, Fiorini L, Munnia A, Hautefeuille A, Malaveille C, Vineis P (2000) White blood cell DNA adducts and fruit and vegetable consumption in bladder cancer. Carcinogenesis 21:183–187

    Article  PubMed  CAS  Google Scholar 

  • Peto J (2001) Cancer epidemiology in the last century and the next decade, Nature 411:390–395

    Article  PubMed  CAS  Google Scholar 

  • Qian GS, Ross RK, Yu MC, Yuan JM, Gao YT, Henderson BE, Wogan GN, Groopman JD (1994) A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People’s Republic of China Cancer Epidemiol Biomarkers Prev 3:3–10

    CAS  Google Scholar 

  • Rebbeck TR, Wang Y, Kantoff PW, Krithivas K, Neuhausen SL, Godwin AK, Daly MB, Narod SA, Brunet JS, Vesprini D, Garber JE, Lynch HT, Weber BL, Brown M (2001) Modification of BRCA1- and BRCA2- associated breast cancer risk by AIB1 genotype and reproductive history, Cancer Res 61:5420–5424

    PubMed  CAS  Google Scholar 

  • Risch HA, McLaughlin JR, Cole DE, Rosen B, Bradley L, Kwan E, Jack E, Vesprini DJ, Kuperstein G, Abrahamson JL, Fan I, Wong B, Narod SA (2001) Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer, Am J Hum Genet 68:700–710

    Article  PubMed  CAS  Google Scholar 

  • Roebuck BD, Liu YL, Rogers AE, Groopman JD, Kensler TW (1991) Protection against aflatoxin Bl-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-l,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry, Cancer Res 51:5501–5506

    PubMed  CAS  Google Scholar 

  • Schairer E, Schoniger E (1943) Lungenkrebs und Tabakverbruch, Zeitschrift fur Krebsforschung 261–269

    Google Scholar 

  • Sozzi G, Conte D, Mariani L, Lo VS, Roz L, Lombardo C, Pierotti MA, Tavecchio L (2001) Analysis of circulating tumor DNA in plasma at diagnosis and during follow-up of lung cancer patients, Cancer Res 61:4675–4678

    PubMed  CAS  Google Scholar 

  • Stellman SD, Djordjevic MV, Muscat JE, Gong L, Bernstein D, Citron ML, White A, Kemeny M, Busch E, Nafziger AN (1998) Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York, Cancer Epidemiol Biomarkers Prev 7:489–496

    PubMed  CAS  Google Scholar 

  • Tang D, Warburton D, Tannenbaum SR, Skipper P, Santella RM, Cereijido GS, Crawford FG, Perera FP (1999) Molecular and genetic damage from environmental tobacco smoke in young children, Cancer Epidemiol Biomarkers Prev 8:427–431

    PubMed  CAS  Google Scholar 

  • Turner PC, Mendy M, Whittle H, Fortuin M, Hall AJ, Wild CP (2000) Hepatitis B infection and aflatoxin biomarker levels in Gambian children, Trop Med Int Health 5:837–841

    Article  PubMed  CAS  Google Scholar 

  • Vineis P, Schulte P, McMichael AJ (2001) Misconceptions about the use of genetic tests in populations, Lancet 357:709–712

    Article  PubMed  CAS  Google Scholar 

  • Wang LY, Hatch M, Chen CJ, Levin B, You SL, Lu SN, Wu MH, Wu WP, Wang LW, Wang Q, Huang GT, Yang PM, Lee HS, Santella RM (1996) Aflatoxin exposure and risk of hepatocellular carcinoma in Taiwan. Int J Cancer 67:620–625

    Article  PubMed  CAS  Google Scholar 

  • Wang JS, Shen X, He X, Zhu YR, Zhang BC, Wang JB, Qian GS, Kuang SY, Zarba A, Egner PA, Jacobson LP, Munoz A, Helzlsouer KJ, Groopman JD, Kensler TW (1999) Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People’s Republic of China, JNCI 91:347–354

    Article  PubMed  CAS  Google Scholar 

  • Weber WW (2001) Effect of pharmacogenetics on medicine, Environmental and Molecular Mutagenesis 37:179–184

    Article  PubMed  CAS  Google Scholar 

  • Wild CP, Hall A J (1999) Hepatitis B virus and liver cancer: Unanswered questions, Cancer Surv 33:35–54

    Google Scholar 

  • Wild CP, Hall AJ (2000) Primary prevention of hepatocellular carcinoma in developing countries, Mutat Res 462:381–393

    Article  PubMed  CAS  Google Scholar 

  • Wild CP, Yin F, Turner PC, Chemin I, Chapot B, Mendy M, Whittle H, Kirk GD, Hall AJ (2000) Environmental and genetic determinants of aflatoxin-albumin adducts in The Gambia. Int J Cancer 86:1–7

    Article  PubMed  CAS  Google Scholar 

  • Xu X, Stower MJ, Reid IN, Garner RC, Burns PA (1996) Molecular screening of multifocal transitional cell carcinoma of the bladder using p53 mutations as biomarkers, Clin Cancer Res 2:1795–1800

    PubMed  CAS  Google Scholar 

  • Yu MC, Mo CC, Chong WX, Yeh FS, Henderson BE (1988) Preserved Foods and Nasopharyngeal Carcinoma: A Case-Control Study in Guangxi, China, Cancer Res 48:1954–1959

    PubMed  CAS  Google Scholar 

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  1. C. P. Wild
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Editors and Affiliations

  1. Unit of Chemoprevention, International Agency for Research on Cancer, 150, cours Albert-Thomas, 69372, Lyon, France

    Harri U. Vainio

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© 2003 Springer-Verlag Berlin Heidelberg

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Wild, C.P. (2003). Molecular Epidemiology in Cancer Prevention. In: Vainio, H.U., Hietanen, E.K. (eds) Mechanisms in Carcinogenesis and Cancer Prevention. Handbook of Experimental Pharmacology, vol 156. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08602-5_17

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  • DOI: https://doi.org/10.1007/978-3-662-08602-5_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-07859-0

  • Online ISBN: 978-3-662-08602-5

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