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Xenobiotic Metabolism and Cancer Susceptibility

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Book cover Mechanisms in Carcinogenesis and Cancer Prevention

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 156))

Abstract

Cancer formation is a very complex process involving changes in numerous genes (Akhurst and Balmain 1999; Sekido et al. 1999; Vähäkangas 2001). Any biological or mechanistic role of xenobiotic metabolizing genes (or rather, their products) in human cancer development must be considered against this basic principle. Consequently, research performed to date most probably gives only a very limited explanation of the associations between polymorphisms in xenobiotic metabolizing genes and individual susceptibility to cancer.

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Authors
  1. O. Pelkonen
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  2. K. Vähäkangas
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  3. H. Raunio
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Editors and Affiliations

  1. Unit of Chemoprevention, International Agency for Research on Cancer, 150, cours Albert-Thomas, 69372, Lyon, France

    Harri U. Vainio

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Pelkonen, O., Vähäkangas, K., Raunio, H. (2003). Xenobiotic Metabolism and Cancer Susceptibility. In: Vainio, H.U., Hietanen, E.K. (eds) Mechanisms in Carcinogenesis and Cancer Prevention. Handbook of Experimental Pharmacology, vol 156. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08602-5_14

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  • DOI: https://doi.org/10.1007/978-3-662-08602-5_14

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