Summary
Cerebral proliferative and tumour forming reticulosis are primary pathologic processes of the brain originating in the perivascular adventitial cell.
In these conditions this cell can transform into a histiocyte or microglial cell with characters of a macrophage. A reactive cell with endoplasmic reticulum, basement membrane and fibril forming properties, is also present (fibril forming reticular cell). The malignant tumours of the perivascular spaces (cerebral reticulosarcoma) are characterized by the presence of the dedifferentiated cells originating from the intraadventitial cell.
Under both proliferative and tumour forming conditions this cell may transform into a cell rich in endoplasmic reticulum, sometimes charged with Russell bodies and corresponds morphologically to the protein-forming plasma cell.
The properties of the intracerebral periadventitial cells are identical with those of the reticulo-histiocytic system described by Aschoff. As its structure and the elements into which it differentiates sharply differ from those of the cells belonging to the lymphocyte series the term malignant lymphoma of the brain given to these processes does not correspond to the fundamental characters of these pathological process.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Dav. d. H.: Elektronenmikroskopische Organpathologie, p. 423. Berlin: VEB-Verlag, 1967.
Vuia, O., Hager, H.: Primary Cerebral Blastomatous Reticulosis. Clinical, Pathological and Ultrastructural Study. J. neurol. Sci. 19, 407–423 (1973).
Marchand, F.: Referat über die Herkunft der Lymphozyten und ihre Schicksale bei der Entzündung. Verh. dtsch. path. Ges. 16, 5–81 (1953).
Draganescu, St., Vuia, O.: Neuroreticuloses. Acta Neuropath. (Berl.) 4, 669–682 (1965).
Horvat, B., Pena, C., Fisher, E.R.: Primary Reticulum cell Sarcoma (Microglioma) of the brain. Arch. Path. 87, 609–616 (1969).
Constantinidis, J., Escourolle, R.: Réticulose pallido-pedonculaire bilatérale et nécrosante. Arch. Suisse Neurol. Neurochir. Psychiat. 106, 223 (1970).
Vuia, O., Mehraien, P.: Cerebral reticuloplasmacytosis with hyperglobu-linemia. Europ. Neurol. 7, 155–168 (1972).
French, J.D.: Plasmacytoma of the Hypothalamus. J. Neuropath. Exp. Neurol. 6, 265–270 (1947).
Moosy, J., Wilson, C.L.B.: Solitary Intracranial Plasmacytoma. Arch. Neurol. 16, 212–216 (1967).
Hager, H.: Ultrastrukturelle Befunde zur Zytopathologie der Entzündung im Zentralnervensystem. Z. allg. Path. 115, 619 (1970).
Weiner, L.P., Anderson, P.N., Allen, J.C.: Cerebral plasmacytoma with myeloma protein in the cerebrospinal fluid. Neurology (Minneap.) 16, 615–618 (1966).
Cutler, R.W., Tourtelotte, W.W.: Synthesis of gammaglobulin inside the blood-brain barrier in subacute sclerosing panencephalitis. Riv. pat. nerv, ment. 92, 163–170 (1971).
Aschoff, L.: Morphologie des retikulo-endothelialen Systems. In Schittenhelm: Handbuch der Krankheiten des Blutes und der blutbildenden Organe. Bd. 2, p. 473, Berlin: Springer 1925.
Russel, D.S., Marshall, A.H.E., Smith, F.B.: Microgliomatosis Brain 71, 1–16 (1948).
Vuia, O., Mehraien, P.: Primary Reticulosis of the Central Nervous System. J. neurol. Sci. 14, 469–482 (1971).
Kernohan, J.W., Uihlein, A.: Sarcomas of the Brain. Springfield, Ill.: Thomas 1962.
Papilian, V.V., Vuia, O., Serban, M., Nagy, I.: Primary Reticulohistio-microglioblastomas of the Central Nervous System. Stud. Cerc. Neurol. 7, 183–192 (1962).
Vuia, O.: Das solitäre und multifokale polymorphe Granulom im Nervensystem. Arch. Psychiat. Neurol. 208, 309–325 (1966).
Poon, P.S., Hirano, A., Zimmerman, H.M.: Electron Microscopic Atlas of the brain Tumours, p. 94. New York, London: Grune & Stratton 1971.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Vuia, O. (1975). Primary Cerebral Reticulosis and Plasma Cell Differentiation. In: Jellinger, K., Seitelberger, F. (eds) Malignant Lymphomas of the Nervous System. Acta Neuropathologica, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08456-4_27
Download citation
DOI: https://doi.org/10.1007/978-3-662-08456-4_27
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-07208-9
Online ISBN: 978-3-662-08456-4
eBook Packages: Springer Book Archive