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Cholesterol and myocardial membrane function

  • Conference paper
Book cover Lipid metabolism in the normoxic and ischaemic heart

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Summary

The incorporation of cholesterol into phospholipid membranes changes the physical properties of the membranes, such as their phase transition, fluidity and homogeneity. In cholesterol-containing phospholipid membranes, integral proteins are surrounded by “annular” phospholipids which exclude cholesterol. Cellular cholesterol is supplied by circulating low-density lipoproteins, and by intracellular de novo synthesis. Cholesterol removal is predominantly handled by circulating high-density lipoproteins. In cardiomyopathic hamsters, myocardial membranes (sarcolemma, mitochondria, sarcoplasmic reticulum) have an increased cholesterol content. In ischaemic myocardium, cholesterol content of sarcolemma fell and that of mitochondria rose. Apparently, cholesterol is redistributed within the ischaemic heart cell. Phospholipids are degraded in sarcolemma, mitochondria and sarcoplasmic reticulum of ischaemic heart cells, probably by activation of phospholipases present in these membrane systems.

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Authors and Affiliations

  1. Department of Cardiology, University Hospital Leiden, Building 1, C5-P024, Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands

    Dr. A. van der Laarse

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  1. Dr. A. van der Laarse
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H. Stam G. J. van der Vusse

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© 1987 Springer-Verlag Berlin Heidelberg

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van der Laarse, A. (1987). Cholesterol and myocardial membrane function. In: Stam, H., van der Vusse, G.J. (eds) Lipid metabolism in the normoxic and ischaemic heart. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-08390-1_17

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  • DOI: https://doi.org/10.1007/978-3-662-08390-1_17

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-662-08392-5

  • Online ISBN: 978-3-662-08390-1

  • eBook Packages: Springer Book Archive

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