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Liquordiagnostik

  • Chapter
Klinische Neurologie

Zusammenfassung

Die zytologische, chemische, bakteriologische und immunologische Analyse der Zerebrospinalflüssig-keit, kurz Liquor, ist ein essentieller Bestandteil der neurologischen Diagnostik. Neben dem Nachweis oder Ausschluß eines entzündlichen erreger- oder autoimmunologisch bedingten Prozesses liefert die Liquoruntersuchung wichtige Hinweise auf neoplastische Erkrankungen der Meningen und des ZNS sowie auf die CT-negative Subarachnoidalblutung. Die Wahl und Dosierung der speziellen Therapeutika bei entzündlichen oder neoplastischen neurologischen Erkrankungen ist in hohem Maße abhängig vom Liquorbefund.

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Literatur

Zitierte Literatur

  • Andersson M, Alvarez-Cermeno J, Bernardi G et al. (1994) Cerebrospinal fluid in the diagnosis of multiple sclerosis: A consensus report. J Neurol Neurosurg Psychiatry 57:897–902

    Article  PubMed  CAS  Google Scholar 

  • Bradbury MWB (1993) Anatomy and physiology of cerebrospinal fluid. In: Schurr PH, Polkey CE (eds) Hydrocephalus. Oxford University Press, Oxford

    Google Scholar 

  • Burkhardt D, Schipper HI, Kaboth U, Felgenhauer K (1992) IgA producing primary intracerebral lymphoma. J Neurol Neurosurg Psychiatry 55:623 – 625

    Article  PubMed  CAS  Google Scholar 

  • Christen HJ, Hanefeld F, Eiffert H, Thomssen R (1993) Epidemiology and clinical manifestation of Lyme borreliosis in childhood. Acta Paediatr Supp 386:1 – 76

    Article  CAS  Google Scholar 

  • Cinque P, Cleator GM, Weber T, Monteyne P, Sindic CJ, Van Coon AM (1996) The role of laboratory investigation in the diagnosis and management of patients with suspected herpes simplex encephalitis: a consensus report. J Neurol Neurosurg Psychiatry 61:339 – 345

    Article  PubMed  CAS  Google Scholar 

  • Cinque P, Scarpellini P, Vago L et al. (1997) Diagnosis of central nervous system complications in HIV-infected patients: cerebrospinal fluid analysis by the polymerase chain reaction. AIDS 11:1–17

    Article  PubMed  CAS  Google Scholar 

  • Conrad AJ, Chiang EY, Andeen LE et al. (1994) Quantitation of intrathecal measles virus IgG antibody synthesis rate: Subacute sclerosing panencephalitis and multiple sclerosis. J Neuroimmunol 54:99 – 108

    Article  PubMed  CAS  Google Scholar 

  • Davson H, Segal MB (1996) Physiology of the CSF and blood-brain barriers. CRC, Boca Raton

    Google Scholar 

  • Denburg JA (1996) Neuronal antibodies. In: Peter JB, Shoenfeld Y (eds) Autoantibodies. Elsevier, Amsterdam, pp 546–550

    Chapter  Google Scholar 

  • Ekstedt J (1978) CSF hydrodynamic studies in man. 2. Normal hydrodynamic variables related to CSF pressure and flow. J Neurol Neurosurg Psychiatry 41:345 – 353

    Article  PubMed  CAS  Google Scholar 

  • Felgenhauer K (1992) Liquordiagnostik. In: Thomas L (Hrsg) Labor und Diagnose, 4. Aufl. Med Verl Ges, Marburg, S 1715–1740

    Google Scholar 

  • Felgenhauer K (1995) Spezielle Pathobiochemie des Liquor-kompartiments. In: Greiling H, Gressner AM (Hrsg) Lehrbuch der klinischen Chemie und Pathobiochemie, 3. Aufl. Schattauer, Stuttgart, S 1065–1085

    Google Scholar 

  • Felgenhauer K, Reiber H (1992) The diagnostic relevance of antibody specificity indices in multiple sclerosis and herpes virus induced diseases of the nervous system. Clin Invest 70:28–37

    Article  CAS  Google Scholar 

  • Reiber H (1995 b) Biophysics of protein diffusion from blood into CSF: The modulation by CSF flow rate. In: Greenwood J, Begley D, Segal M (eds) New concepts of a blood-brain barrier. Plenum, London, pp 219–227

    Google Scholar 

  • Reiber H (1995 c) Die diagnostische Bedeutung neuroimmun-ologischer Reaktionsmuster im Liquor cerebrospinalis. Lab Med 19:444–462

    CAS  Google Scholar 

  • Reiber H (1996) Evaluation of blood-CSF barrier function and quantification of the humoral immune response within the CNS. In: Thompson EJ, Trojano M, Livrea P (eds) Cerebrospinal fluid analysis in multiple sclerosis. Springer, Mailand, pp 51–72

    Chapter  Google Scholar 

  • Reiber H (1997) CSF flow — Its influence on CSF concentrations of brain-derived and blood-derived proteins. In: Teelken A, Korf J (eds) Neurochemistry. Plenum, New York, pp 423–432

    Google Scholar 

  • Reiber H, Felgenhauer K (1987) Protein transfer at the blood cerebrospinal fluid barrier and the quantitation of the humoral immune response within the central nervous system. Clin Chim Acta 163:319–328

    Article  PubMed  CAS  Google Scholar 

  • Reiber H, Lange P (1991) Quantification of virus-specific antibodies in cerebrospinal fluid and serum: Sensitive and specific detection of antibody synthesis in brain. Clin Chem 37:1153–1160

    PubMed  CAS  Google Scholar 

  • Reiber H, Thiele P (1983) Species-dependent variables in blood cerebrospinal fluid function for proteins. J Clin Chem Clin Biochem 21:199–202

    PubMed  CAS  Google Scholar 

  • Reiber H, Ruff M, Uhr M (1993) Ascorbate concentration in human cerebrospinal fluid (CSF) and serum. Intrathecal accumulation and CSF flow rate Clin Chim Acta 217: 163–173

    Article  PubMed  CAS  Google Scholar 

  • Reiber H, Ungefehr St, Jacobi C (1997) The intrathecal, polys-pecific and oligoclonal immune response in multiple sclerosis. Multiple Sclerosis, submitted

    Google Scholar 

  • Reiber H, Sindic C, Thompson EJ (1999) Cerebrospinal fluid clinical neurochemistry of neurological diseases. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Rieckmann P, Weber T, Felgenhauer K (1990) Class differentiation of immunoglobulin-containing cerebrospinal fluid cells in inflammatory diseases of the central nervous system. Klin Wochenschr 68:12 – 17

    Article  PubMed  CAS  Google Scholar 

  • Rieckmann P, Martin S, Weichselbaum I et al. (1994) Serial analysis of circulating adhesion molecules and TNF receptor in serum from patients with multiple sclerosis. Neurology 44:2367–2372

    Article  PubMed  CAS  Google Scholar 

  • Saito Y, Wright EM (1984) Regulation of bicarbonate transport across the brush border membrane of the bull-frog choroid plexus. J Physiol 350:327 – 342

    PubMed  CAS  Google Scholar 

  • Schaarschmidt H, Prange H, Reiber H (1994) Neuron-specific enolase concentrations in blood as a prognostic parameter in cerebrovascular diseases. Stroke 24:558 – 565

    Article  Google Scholar 

  • Schmidt RM (1978) Atlas der Liquorzytologie. Barth, Leipzig

    Google Scholar 

  • Schmidt RM (1987) Der Liquor cerebrospinalis. Untersuchungsmethoden und Diagnostik, 2. Aufl, Bde I und IL Fischer, Stuttgart

    Google Scholar 

  • Shoji H, Honda Y, Murai I, Sato Y, Oizumik K, Hondo R (1992) Detection of VZV-DNA by polymerase chain reaction in CSF of patients with herpes zoster meningitis. J Neurol 239:69 – 70

    Article  PubMed  CAS  Google Scholar 

  • Sindic CJM, Monteyne PH, Laterre EC (1994) The intrathecal synthesis of virus-specific oligoclonal IgG in multiple sclerosis. J Neuroimmunol 54:75 – 80

    Article  PubMed  CAS  Google Scholar 

  • Terryberry JW, Shoenfeld Y, Gilburd B et al. (1995) Myelin- and microbe-specific antibodies in Guillain-Barré Syndrome. J Clin Lab Anal 9(5):308–319

    Article  PubMed  CAS  Google Scholar 

  • Thompson EJ (1988) The CSF proteins: A biochemical approach. Elsevier, Amsterdam

    Google Scholar 

  • Thompson EJ, Trojano M, Livrea P (1996) Cerebrospinal fluid analysis in multiple sclerosis. Springer, Mailand

    Book  Google Scholar 

  • Trendelenburg C (1994) Labormedizinische Spezialbefundung und ärztliche Verantwortung. Interpretation of special findings in laboratory medicine and medical responsibility. Lab Med 18:545–551

    Google Scholar 

  • Tumani H, NöTker G, Reiber H (1995) Relevance of cerebrospinal fluid parameters for early diagnosis in neurobor-reliosis. Neurology 45:1663 – 1670

    Article  PubMed  CAS  Google Scholar 

  • Vandvic B, Norrby E (1973) Oligoclonal IgG antibody response in the CNS to different measles virus antigens in subacute sclerosing panencephalitis. Proc Natl Acad Sei 70:1060 – 1063

    Article  Google Scholar 

  • Vandvic B, Norrby E, Nordal HJ (1979) Optic neuritis: local synthesis in the CNS of oligoclonal antibodies to measles, mumps, rubella and herpes simplex viruses. Acta Neurol Scand 60:204–213

    Article  Google Scholar 

  • Vandvic B, Nilsen RE, Vardal F, Norrby E (1982) Mumps meningitis: specific and non-specific antibody responses in the CNS. Acta Neurol Scand 65:468 – 487

    Article  Google Scholar 

  • Varela F J, Coutinho A (1991) Second generation immune networks. Immunol Today 12:159–166

    PubMed  CAS  Google Scholar 

  • Weber T, Jürgens S, Liier W (1987) Cerebrospinal fluid immunoglobulins and virus-specific antibodies in disorders affecting the facial nerve. J Neurol 234:308–314

    Article  PubMed  CAS  Google Scholar 

  • Weber T, Frye S, Bodemer M et al. (1996) Clinical implications of nucleic acid amplification methods for the diagnosis of viral infections of the nervous system. J Neuro Virol 2:175–190

    CAS  Google Scholar 

  • Wood JH (1980,1983) Neurobiology of cerebrospinal fluid, vols 1 and 2. Plenum, New York

    Book  Google Scholar 

  • Zerr I, Bodemer M, Racker S et al. (1995) Cerebrospinal fluid concentration of neuron-specific enolase in diagnosis of Creutzfeldt-Jakob disease. Lancet 345:1609–1610

    Article  PubMed  CAS  Google Scholar 

  • Zerr I, Bodemer M, Otto M et al. (1996) Diagnosis of Creutzfeldt-Jakob disease by two-dimensional gel electrophoresis of cerebrospinal fluid. Lancet 348:846 – 849

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. H. Reiber
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Editors and Affiliations

  1. Klinik für Neurologie mit Klinischer Neurophysiologie, Alfried-Krupp-Krankenhaus, Alfried-Krupp-Straße 21, D-45131, Essen, Deutschland

    Peter Berlit

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© 1999 Springer-Verlag Berlin Heidelberg

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Reiber, H. (1999). Liquordiagnostik. In: Berlit, P. (eds) Klinische Neurologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08118-1_6

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  • DOI: https://doi.org/10.1007/978-3-662-08118-1_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-08119-8

  • Online ISBN: 978-3-662-08118-1

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