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Pharmakologische Endokrinologie

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Klinische Endokrinologie für Frauenärzte

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Zusammenfassung

Unter den Sexualsteroiden unterscheidet man bekanntlich nach ihren Hauptwirkungen Östrogene von Androgenen und progesteronähnlichen Substanzen (Gestagenen). Das im geschlechtsreifen Alter der Frau biologisch aktivste Östrogen ist das 17β-Östradiol, das natürliche Gestagen ist das Progesteron, das Hauptandrogen beim Mann Testosteron. Letzteres muß allerdings in vielen Zielorganen in Dihydrotestosteron, das an den androgensensiblen Zellen eigentlich wirksame Androgen, umgewandelt werden. An vielen Zielorganen (z. B. an der Haut und am äußeren Genitale) ist diese Umwandlung Voraussetzung für die androgene Wirkung.

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Literatur

  • Asch RH, Fernandez EO, Siler-Khodr TM et al. (1980) Mechanism of induction of luteal phase defects by danazol. Am J Obstet Gynecol 136: 932

    PubMed  CAS  Google Scholar 

  • Barbieri R, Ryan KJ (1985) Medical therapy for endometriosis: Endocrine pharmacology. In: Sem Reprod Endocrinol 3: 339

    Article  Google Scholar 

  • Bartosik D (1985) Immunologic aspects of endometriosis. Sem-Reprod Endocrinol 3: 329

    Article  Google Scholar 

  • Baulieu EE (1985) RU 486: An antiprogestin steroid with contragestive activity in women. In: Beaulieu EE, Segal SJ (eds) The antiprogestin steroid RU 486 and human fertility control. Plenum, New York, p 1

    Chapter  Google Scholar 

  • Belghmi K, Michel F, Nicolas JC et al. (1984) Inhibition of enzymes involved in steroid and prostanoid metabolism by steroid used in endometriosis therapy. In: Raynand JP (eds) Medical management of endometriosis. Raven, New York, p 91

    Google Scholar 

  • Bentley PJ (1980) The endocrinology and pharmacology of reproduction. In: Bentley PJ (eds) Endocrine pharmacology. Cambridge Univ Press, Cambridge, p 270

    Google Scholar 

  • Bohnet HG, Hanker JP, Schweppe KW, Schneider HPG (1981) Changes of prolactin secretion following long term danazol application. Fertil Steril 25: 728

    Google Scholar 

  • Braun P, Leyendecker G (1981) The effect of danazol on LH episodes, basal LH and FSH serum levels, estradiol induced positive feedback and LH-RH induced gonadotropin release in the follicular phase of the menstrual cycle. Acta Endocrinol [Suppl] 243: 190A

    Google Scholar 

  • Breckenridge AM, Back DJ, Orme M (1989) Effect of disease and drug interactions on the response to oral contraceptive steroids. In: Michael F (eds) Safety requirements for contraceptive steroids. Cambridge Univ. Press, Cambridge, p 348

    Google Scholar 

  • Briggs MH, Briggs M (1971) Effect of oral ethinyl estradiol on serum proteins in normal women. Contraception 3: 381

    Article  CAS  Google Scholar 

  • Briggs MH, Briggs M (1985) Pharmacology of hormonal contraceptives. In Shearman RP (eds) Clinical reproductive endocrinology. Churchill Livingston, Edinburgh, p 656

    Google Scholar 

  • Clark JH, Peck EJ Jr, Anderson JN (1974) Oestrogen receptors and antagonism of steroid hormone action. Nature 251: 446

    Article  PubMed  CAS  Google Scholar 

  • Dmowski WP, Headley S, Radwanka E (1983) Effects of danazol on pulsatile gonadotropin patterns and on serum estradiol levels in normal cycling women. Fertil Steril 39: 49

    PubMed  CAS  Google Scholar 

  • Edgren RA (1980) Progestagens. In: Clinical use of sex steroids. Yearbook Medical, Chicago, p 1

    Google Scholar 

  • Elias AN, Gwinup G (1980) Effects of some clinically encountered drugs on steroid synthesis and degradation. Metabolism 29: 582

    Article  PubMed  CAS  Google Scholar 

  • Franchimont P, Cramilion C (1977) The effect of danazol on anterior pituitary function. Fertil Steril 28: 814

    PubMed  CAS  Google Scholar 

  • Fraser IS (1983) Post danazol amenorrhea. Clin Reprod Fertil 2: 229

    PubMed  CAS  Google Scholar 

  • Gravanis A, Schaison G, George M, De Brux J, Satyaswaroop PG, Baulieu EE, Robel P (1985) Endometrial and pituitary responses to the steroidal antiprogestin RU 486 in postmenopausal women. J Clin Endocrinol Metab 60: 156

    Article  PubMed  CAS  Google Scholar 

  • Gurpide E (1983) Antiestrogenic actions of progesterone and-progestins in women. In: Bardin CE et al. (eds) Progesterone and progestins. Raven, New York, p 149

    Google Scholar 

  • Hammerstein J (1979) In: Hammerstein J et al. (eds) Androgenisierungserscheinungen bei der Frau. Excerpta Medica, Amsterdam, p 298

    Google Scholar 

  • Haspels AA (1985) Interruption of early pregnancy by an antiprogestational compound RU 486. Eur J Obstet Gynecol Reprod Biol 20: 169

    Article  PubMed  CAS  Google Scholar 

  • Healy DL (1985) Clinical status of antiprogesterone steroids. Clin Reprod Fertil 3: 277

    PubMed  CAS  Google Scholar 

  • Healy DL, Chrousos GP, Schulte HM, Williams RF, Gold PW, Baulieu E, Hodgen GD (1983) Pituitary and adrenal responses to the antiprogesterone and antiglucocorticoid steroid RU 486 in primates. J Clin Endocrinol Metab 57: 863

    Article  PubMed  CAS  Google Scholar 

  • Herrmann WL, Schindler HM, Wyss R, Bischof P (1985) Effects of the antiprogesterone RU 486 in early pregnancy and during the menstrual cycle. In: Baulieu EE, Segal SJ (eds) The antiprogesterone steroid RU 486 and human fertility control. Plenum, New York, p 179

    Chapter  Google Scholar 

  • Johansson EDB (1971) Depression of the progesterone levels in women treated with synthetic gestagens after ovulation. Acta Endocrinol (Copenh) 68: 779

    CAS  Google Scholar 

  • Keller PJ (1986) Chemie und Pharmakologie der synthetischen-Gestagene. In: Kontrazeptive Gestagene. Thieme, Stuttgart, S3

    Google Scholar 

  • Kopera H (1988) Vortragsmanuskript Fortbildungsseminar für Endokrinologie und Reproduktionsmedizin, Hamburg

    Google Scholar 

  • Kovacs L, Sas M, Resch BA, Ugocsai G, Swahn ML, Bygdeman M, Rowe PJ (1984) Termination of very early pregnancy by RU 486 — an antiprogestational compound. Contraception 29: 399

    Article  PubMed  CAS  Google Scholar 

  • Kuhl H (1987) Progestagene zur Empfängnisverhütung. Dtsch Med Wochensch 18/19: 433

    Google Scholar 

  • Kuhl H, Taubert HD (1987) Das Klimakterium. Pathophysiologic — Klinik Therapie. Thieme, Stuttgart

    Google Scholar 

  • Lauersen NG, Wilson KH (1977) Evaluation of danazol as an oral contraceptive. Obstet Gynecol 50: 91

    PubMed  CAS  Google Scholar 

  • Lauritzen Ch (1987) Hormonale Kontrazeption. Med wiss Buchreihe, Schering AG, Adam Pharma, Essen, S 60

    Google Scholar 

  • Leyendecker G, Wildt L (1984) Pulsatile Therapie der hypothalamischen Amenorrhoe mit Gonadotropin releasing Hormon. Dtsch med Wochenschr 109: 462

    Article  PubMed  CAS  Google Scholar 

  • Moguilewsky M, Philibert D (1984) RU 38486: Potent antiglucocorticoid activity correlated with strong binding to the cytosolic glucocorticoid receptor followed by an impaired activation. J Steroid Biochem 20: 271

    Article  PubMed  CAS  Google Scholar 

  • Nilsson B, Sodergaard R, Damber MG et al. (1983) Free testosterone levels during danazol therapy. Fertil Steril 39: 505

    PubMed  CAS  Google Scholar 

  • Nicholson RE, Griffiths K (1980) The biochemistry of tamoxifen action. In: Thomas JA et al. (eds) Advances in sex hormone research, vol 4. Urban & Schwarzenberg, München, p 119

    Google Scholar 

  • Ottosson UB, Nilsson B, Södergaard R, von Schoultz B (1985) Effects of progesterone, progestogens and danazol on the specific Cortisol binding in human plasma. Fertil Steril 43: 856

    PubMed  CAS  Google Scholar 

  • Reimers DU (1973) Rifampicin and ovulation inhibitors. Sixtyfourth meeting of the professional society of lung and bronchial specialists. Berlin, February, 19

    Google Scholar 

  • Reyniak KV, Gurpide E (1982) Effect of danazol on gonadal steroidogenesis in patients with a complete form of testicular feminization. Am J Obstet Gynecol 142: 479

    PubMed  CAS  Google Scholar 

  • Runnebaum R, Rabe T (1987) New progestogens in oral contraceptives. Am J Obstet Gynecol 157: 1059

    PubMed  CAS  Google Scholar 

  • Schweppe KW (1988) Medikamentöse Behandlung der Endometriose. Gynäkologe 21: 52

    PubMed  CAS  Google Scholar 

  • Schweppe KW, Assmann G (1984) Changes of plasma lipids and lipoprotein levels during danazol treatment for endometriosis. Horm Metab Res 16: 593

    Article  PubMed  CAS  Google Scholar 

  • Taubert HD, Kuhl H (1981) Kontrazeption mit Hormonen. Thieme, Stuttgart, S 76

    Google Scholar 

  • Teichmann AT, Wieland H, Brockerhoff P (1989) Sexualhormone, Arteriosklerose und Fettstoffwechsel der Frau. Wiss Verlagsbuchhandlung, Stuttgart

    Google Scholar 

  • Vickery BH, Nestor JJ Jr (1987) LH-RH analogs: Development and mechanism of actions. Sem Reprod Endocrinol 5: 353

    Article  Google Scholar 

  • Victor A, Weiner E, Johansson EDB (1976) Sex hormone binding globulin: The carrier protein for d-norgestrel. J Clin Endocrinol 43: 244

    Article  CAS  Google Scholar 

  • Waibel-Treber S, Minne HW, Scharia SH, Bremen TH, Ziegler R, Leyendecker G (1989) Reversible bone loss in women treated with GnRH agonist for endometriosis and uterine leiomyomas. Hum Reprod 4: 384

    PubMed  CAS  Google Scholar 

  • Wentz AC, Sapp KC (1978) Danazol as a luteolytic agent. Fertil Steril 29: 23

    PubMed  CAS  Google Scholar 

  • Wright F, Giacomini M, Riati M, Mowszowicz I (1983) Antihormone activity of progesterone and progestins. In: Bardin CW et al (eds) Progesterone and progestins. Raven, New York, p 121

    Google Scholar 

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Authors and Affiliations

  1. Institut für Hormon- und Fortpflanzungsforschung, Lornsenstraße 4, W-2000, Hamburg 50, Deutschland

    Professor Dr. med. Freimut A. Leidenberger

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  1. Professor Dr. med. Freimut A. Leidenberger
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© 1992 Springer-Verlag Berlin Heidelberg

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Leidenberger, F.A. (1992). Pharmakologische Endokrinologie. In: Klinische Endokrinologie für Frauenärzte. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08110-5_10

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  • DOI: https://doi.org/10.1007/978-3-662-08110-5_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-08111-2

  • Online ISBN: 978-3-662-08110-5

  • eBook Packages: Springer Book Archive

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