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Intracellular Antibodies pp 145–171Cite as

Plantibodies: Immunomodulation and Immunotherapeutic Potential

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Part of the book series: Biotechnology Intelligence Unit ((BIOIU))

Abstract

Plants are currently being explored and exploited as an important system for the expression of recombinant proteins from different sources and represent the next wave in the production of bioactive proteins, either to improve plant performance itself or to be used as biofactories of high-value therapeutic products.1 This chapter describes recent trends and achievements in the field of “plantibodies” (plant produced antibodies), a rapidly evolving field since the original description of antibodies produced in plants.2 Antibody engineering has proved to be a powerful means of modifying immunoglobulin genes to be functionally expressed also in biological systems different from lymphoid cells. Among these systems higher plants may well be considered effective hosts for heterologous expression. In fact, the general capability and adaptability of plants to transformation techniques and expression of immunoglobulin genes as well as to antibody processing and assembly (matching quite closely that of native cells) make plants particularly advantageous for many biotechnological applications.

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Authors
  1. Rosella Franconi
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  2. Paraskevi Tavladoraki
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  3. Eugenio Benvenuto
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Editors and Affiliations

  1. Biophysics Sector, International School for Advanced Studies (SISSA), Via Beirut 2/4, 34013, Trieste, Italy

    Antonino Cattaneo Ph.D.

  2. Department of Experimental Medicine and Biochemical Sciences, University of Rome “Tor Vergata”, Via di Tor Vergata 135, 00133, Roma, Italy

    Silvia Biocca Ph.D.

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Franconi, R., Tavladoraki, P., Benvenuto, E. (1997). Plantibodies: Immunomodulation and Immunotherapeutic Potential. In: Cattaneo, A., Biocca, S. (eds) Intracellular Antibodies. Biotechnology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07992-8_9

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  • DOI: https://doi.org/10.1007/978-3-662-07992-8_9

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